About Enhancer
| Enhancer ID: | E_02_0523 |
| Species: | human |
| Position : | chr17:72118219-72120219   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Osteoarthritis |
| Pubmed ID: | 30021842 |
| Enhancer experiment: | RNA-seq,qRT-PCR,ChIP-seq |
| Enhancer experiment description: | SOX9 controls cell lineage fate and differentiation in major biological processes. By profiling the whole transcriptome and the whole epigenome of wild-type and Sox9-deficient mouse embryo limb buds, we uncover multiple structural and regulatory genes, including Fam101a, Myh14, Sema3c and Sema3d, as specific markers of precartilaginous condensation, and we provide evidence of their direct transactivation by SOX9. |
About Target gene
| Target gene : | SOX9(CMD1,CMPD1,SRA1,SRXX2,SRXY10),Myh14 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | SOX9 controls cell lineage fate and differentiation in major biological processes. By profiling the whole transcriptome and the whole epigenome of wild-type and Sox9-deficient mouse embryo limb buds, we uncover multiple structural and regulatory genes, including Fam101a, Myh14, Sema3c and Sema3d, as specific markers of precartilaginous condensation, and we provide evidence of their direct transactivation by SOX9.;SOX9 controls cell lineage fate and differentiation in major biological processes. By profiling the whole transcriptome and the whole epigenome of wild-type and Sox9-deficient mouse embryo limb buds, we uncover multiple structural and regulatory genes, including Fam101a, Myh14, Sema3c and Sema3d, as specific markers of precartilaginous condensation, and we provide evidence of their direct transactivation by SOX9. |
About TF
| TF name : | -- |
| TF experiment: | RNA-seq,qRT-PCR,ChIP-seq |
| TF experiment description: | SOX9 controls cell lineage fate and differentiation in major biological processes. By profiling the whole transcriptome and the whole epigenome of wild-type and Sox9-deficient mouse embryo limb buds, we uncover multiple structural and regulatory genes, including Fam101a, Myh14, Sema3c and Sema3d, as specific markers of precartilaginous condensation, and we provide evidence of their direct transactivation by SOX9.;SOX9 controls cell lineage fate and differentiation in major biological processes. By profiling the whole transcriptome and the whole epigenome of wild-type and Sox9-deficient mouse embryo limb buds, we uncover multiple structural and regulatory genes, including Fam101a, Myh14, Sema3c and Sema3d, as specific markers of precartilaginous condensation, and we provide evidence of their direct transactivation by SOX9. |
About Function
| Enhancer function : | SOX9 controls cell lineage fate and differentiation in major biological processes. By profiling the whole transcriptome and the whole epigenome of wild-type and Sox9-deficient mouse embryo limb buds, we uncover multiple structural and regulatory genes, including Fam101a, Myh14, Sema3c and Sema3d, as specific markers of precartilaginous condensation, and we provide evidence of their direct transactivation by SOX9. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
SOX9 controls cell lineage fate and differentiation in major biological processes. By profiling the whole transcriptome and the whole epigenome of wild-type and Sox9-deficient mouse embryo limb buds, we uncover multiple structural and regulatory genes, including Fam101a, Myh14, Sema3c and Sema3d, as specific markers of precartilaginous condensation, and we provide evidence of their direct transactivation by SOX9. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene