About Enhancer
| Enhancer ID: | E_02_0558 |
| Species: | mouse |
| Position : | chr10:126881408-126883408   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 33553989 |
| Enhancer experiment: | -- |
| Enhancer experiment description: | Our recent genomic studies identified a complex kidney?specific enhancer module located within the introns of adjacent Mettl1 (M1) and Mettl21b (M21) genes that mediate basal and PTH induction of Cyp27b1, as well as suppression by FGF23 and 1,25?dihydroxyvitamin D3 [1,25(OH)2D3]. |
About Target gene
| Target gene : | Cyp27b1 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Our recent genomic studies identified a complex kidney?specific enhancer module located within the introns of adjacent Mettl1 (M1) and Mettl21b (M21) genes that mediate basal and PTH induction of Cyp27b1, as well as suppression by FGF23 and 1,25?dihydroxyvitamin D3 [1,25(OH)2D3]. |
About TF
| TF name : | -- |
| TF experiment: | -- |
| TF experiment description: | Our recent genomic studies identified a complex kidney?specific enhancer module located within the introns of adjacent Mettl1 (M1) and Mettl21b (M21) genes that mediate basal and PTH induction of Cyp27b1, as well as suppression by FGF23 and 1,25?dihydroxyvitamin D3 [1,25(OH)2D3]. |
About Function
| Enhancer function : | Our recent genomic studies identified a complex kidney?specific enhancer module located within the introns of adjacent Mettl1 (M1) and Mettl21b (M21) genes that mediate basal and PTH induction of Cyp27b1, as well as suppression by FGF23 and 1,25?dihydroxyvitamin D3 [1,25(OH)2D3]. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Our recent genomic studies identified a complex kidney?specific enhancer module located within the introns of adjacent Mettl1 (M1) and Mettl21b (M21) genes that mediate basal and PTH induction of Cyp27b1, as well as suppression by FGF23 and 1,25?dihydroxyvitamin D3 [1,25(OH)2D3]. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene