About Enhancer
| Enhancer ID: | E_02_0745 |
| Species: | human |
| Position : | chr11:89321560-89323560   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Disc pathologies |
| Pubmed ID: | 32025238 |
| Enhancer experiment: | SA- ?- Gal staining, edu staining, transfection, Western blot, immunofluorescence, immunohistochemistry, RT-qPCR, ROS measurement, flow cytometry, chip |
| Enhancer experiment description: | NADPH oxidase 4 (NOX4)-associated oxidative stress has been shown to induce pre_x0002_mature NP cell senescence. Enhancer of zeste homolog 2 (EZH2) is a crucial gene regulating cell senescence |
About Target gene
| Target gene : | NOX4 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | NADPH oxidase 4 (NOX4)-associated oxidative stress has been shown to induce pre_x0002_mature NP cell senescence. Enhancer of zeste homolog 2 (EZH2) is a crucial gene regulating cell senescence |
About TF
| TF name : | -- |
| TF experiment: | SA-?-gal ???EDU??????Western blot???????????RT-QPCR,ROS ??,??????ChIP |
| TF experiment description: | NADPH oxidase 4 (NOX4)-associated oxidative stress has been shown to induce pre_x0002_mature NP cell senescence. Enhancer of zeste homolog 2 (EZH2) is a crucial gene regulating cell senescence |
About Function
| Enhancer function : | NADPH oxidase 4 (NOX4)-associated oxidative stress has been shown to induce pre_x0002_mature NP cell senescence. Enhancer of zeste homolog 2 (EZH2) is a crucial gene regulating cell senescence |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
NADPH oxidase 4 (NOX4)-associated oxidative stress has been shown to induce pre_x0002_mature NP cell senescence. Enhancer of zeste homolog 2 (EZH2) is a crucial gene regulating cell senescence |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene