About Enhancer
| Enhancer ID: | E_02_0772 |
| Species: | human |
| Position : | chr2:75120051-75165771   |
| Biosample name: | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 29273679 |
| Enhancer experiment: | Hi-C,4C,ChIP-seq |
| Enhancer experiment description: | In order to gain insights into TAD organization around the HoxD locus during limb bud development, we performed Hi-C (chromosome capture followed by high-throughput sequencing) on microdissected distal and proximal limb bud cells isolated from embryonic day 12.5 (E12.5) embryos. At this stage, T-DOM enhancers regulate Hoxd gene expression in proximal cells and are silent in distal cells, whereas C-DOM enhancers control Hoxd gene targets in future digit cells and are silent in proximal cells. Therefore, the two TADs are either transcriptionally active or inactive in an exclusive manner in the two tissue samples (Fig. 1A,B, top schemes). |
About Target gene
| Target gene : | Hoxd |
| Strong evidence: | 4C |
| Less strong evidence: | Hi-C,qPCR |
| Target gene experiment description: | Consequently,under wild-type conditions, Hoxd4 is expressed only in proximal limb cells under the control of the T-DOM,while C-DOM Enhancers control Evx2 transcripts in dis_x0002_tal cells exclusively. |
About TF
| TF name : | -- |
| TF experiment: | -- |
| TF experiment description: | -- |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene