About Enhancer

Enhancer ID: E_02_0779
Species: mouse
Position : chr8:11564419-11614821
Biosample name:
Experiment class : Low+High throughput
Enhancer type: Super-Enhancer
Disease: --
Pubmed ID:  29078395
Enhancer experiment: ChIP-seq,ChIA-PET
Enhancer experiment description: To clarify how distal enhancer elements within superenhancer loci form enhancer-promoter loops and chromatin interactions, we performed RNA Pol II-based chromatin interaction analysis by paired-end tag (ChIA-PET) sequencing (24, 25) using mouse CD4+ T cells that were preactivated by TCR stimulation (anti-CD3 plus anti-CD28) and then not treated or treated with IL-2 for 4 h.Interestingly, both H3K4me3 (blue peaks in Fig. 3, primarily at the promoter) and H3K27Ac (green peaks in Fig. 3, spanning the Il2ra superenhancer region; also shown in Fig. 1E) were strong after TCR preactivation and only modestly affected by stimulation with IL-2, in marked contrast to the changes in STAT5 binding and chromatin looping.

About Target gene

Target gene : Il2ra(CD25,IDDM10,IL2R,IMD41,TCGFR,p55)
Strong evidence: --
Less strong evidence: ChIP-seq,RNA-seq
Target gene experiment description: As noted above, STAT5 and H3K27Ac are highly enriched at a subset of superenhancers, including at the Il2ra superenhancer (Fig. 1 A, B, and E), correlating with IL-2induced gene expression (Fig. 2B and Fig. S1C). We also found extensive H3K27Ac and STAT5 binding at the human IL2RA locus (Fig. S2), analogous to the mouse Il2ra superenhancer, with significant conservation of some of the enhancer elements (Fig. S2).

About TF

TF name : Stat5a(AA959963,STAT5)Stat3(ADMIO,ADMIO1,APRF,HIES)
TF experiment: ChIP-seq,CRISPR/Cas9
TF experiment description: Based on our genome-wide analysis of chromatin immunoprecipitation coupled to DNA sequencing (ChIP-Seq) profiles, we observed that STAT5-enriched Super-Enhancers spanned large genomic regions (average size of ?19 kb) and indeed were associated with high levels of H3K27Ac.

About Function

Enhancer function : --
Enhancer function experiment: --
Enhancer function
experiment description:		 --

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
Stat5a Angiopoietin receptor Tie2-mediated signaling pid 50
Stat5a CD40/CD40L signaling pid 36
Stat5a CXCR4-mediated signaling events pid 87
Stat5a Downstream signal transduction reactome 29
Stat5a EGF receptor signaling pathway panther 109
Stat5a EGFR1 netpath 475
Stat5a EPO signaling pathway pid 33
Stat5a EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) inoh 12
Stat5a ErbB4 signaling events pid 35
Stat5a Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 14
Stat5a Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 8
Stat5a Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 8
Stat5a Glucocorticoid receptor regulatory network pid 85
Stat5a GMCSF-mediated signaling events pid 38
Stat5a Growth hormone receptor signaling reactome 24
Stat5a Growth hormone signaling pathway(JAK2 STAT5) ( Growth hormone signaling(JAK2 STAT5) ) inoh 9
Stat5a IL-2 signaling pathway(JAK1 JAK3 STAT5) ( IL-2 signaling(JAK1 JAK3 STAT5) ) inoh 7
Stat5a IL-3 signaling pathway(JAK1 JAK2 STAT5) ( IL-3 signaling(JAK1 JAK2 STAT5) ) inoh 7
Stat5a IL-5 signaling pathway(JAK1 JAK2 STAT1 STAT5) ( IL-5 signaling(JAK1 JAK2 STAT1 STAT5) ) inoh 11
Stat5a IL-7 netpath 28
Stat5a IL-7 signaling pathway(JAK1 JAK3 STAT5) ( IL-7 signaling(JAK1 JAK3 STAT5) ) inoh 13
Stat5a IL12-mediated signaling events pid 62
Stat5a IL2-mediated signaling events pid 54
Stat5a IL2 netpath 81
Stat5a IL2 signaling events mediated by STAT5 pid 30
Stat5a IL23-mediated signaling events pid 37
Stat5a IL27-mediated signaling events pid 26
Stat5a IL3-mediated signaling events pid 27
Stat5a IL3 netpath 84
Stat5a IL4-mediated signaling events pid 66
Stat5a IL4 netpath 75
Stat5a IL5-mediated signaling events pid 14
Stat5a IL5 netpath 59
Stat5a IL6 netpath 85
Stat5a IL9 netpath 24
Stat5a Interleukin-2 signaling reactome 14
Stat5a Interleukin-3, 5 and GM-CSF signaling reactome 24
Stat5a Interleukin-7 signaling reactome 11
Stat5a Interleukin signaling pathway panther 86
Stat5a JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 97
Stat5a JAK/STAT signaling pathway panther 15
Stat5a KitReceptor netpath 104
Stat5a Leptin netpath 98
Stat5a Nuclear signaling by ERBB4 reactome 25
Stat5a PDGF signaling pathway (Mammal) ( PDGF signaling pathway ) inoh 29
Stat5a PDGF signaling pathway panther 113
Stat5a PDGFR-beta signaling pathway pid 125
Stat5a Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 178
Stat5a Prolactin netpath 105
Stat5a Prolactin receptor signaling reactome 15
Stat5a RAC1 signaling pathway pid 54
Stat5a Signaling by cytosolic FGFR1 fusion mutants reactome 18
Stat5a Signaling by Leptin reactome 11
Stat5a Signaling by SCF-KIT reactome 37
Stat5a Signaling events mediated by PTP1B pid 53
Stat5a Signaling events mediated by Stem cell factor receptor (c-Kit) pid 53
Stat5a Signaling events mediated by TCPTP pid 40
Stat5a TCR netpath 261
Stat5a TNFalpha netpath 274
Stat5a Trk receptor signaling mediated by PI3K and PLC-gamma pid 36
Stat5a TSLP netpath 24
Stat5a Validated nuclear estrogen receptor alpha network pid 65
Stat5a ErbB signaling pathway kegg 83
Stat5a Jak-STAT signaling pathway kegg 149
Stat5a Pathways in cancer kegg 321
Stat5a Chronic myeloid leukemia kegg 69
Stat5a Acute myeloid leukemia kegg 53
Stat5a Hs_Interferon_type_I_signaling_pathways_WP585_85198 wikipathways 35
Stat5a Hs_Tryptophan_metabolism_WP465_85055 wikipathways 45
Stat5a Hs_TYROBP_Causal_Network_WP3945_90843 wikipathways 54
Stat5a Hs_ErbB_Signaling_Pathway_WP673_91869 wikipathways 37
Stat5a Hs_Association_Between_Physico-Chemical_Features_and_Toxicity_Associated_Pathways_WP3680_90113 wikipathways 31
Stat5a Hs_Regulation_of_Actin_Cytoskeleton_WP51_79977 wikipathways 36
Stat5a Hs_Bladder_Cancer_WP2828_89143 wikipathways 17
Stat5a Hs_Kit_receptor_signaling_pathway_WP304_78799 wikipathways 46
Stat5a Hs_IL-5_Signaling_Pathway_WP127_78498 wikipathways 35
Stat5a Hs_IL-2_Signaling_Pathway_WP49_91243 wikipathways 33
Stat5a Hs_Prolactin_Signaling_Pathway_WP2037_90015 wikipathways 52
Stat5a Hs_AGE-RAGE_pathway_WP2324_89798 wikipathways 27
Stat5a Hs_IL-4_Signaling_Pathway_WP395_89828 wikipathways 41
Stat5a Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 wikipathways 107
Stat5a Hs_IL-3_Signaling_Pathway_WP286_78583 wikipathways 35
Stat5a Hs_IL-7_Signaling_Pathway_WP205_89854 wikipathways 16
Stat3 AndrogenReceptor netpath 167
Stat3 Angiogenesis panther 141
Stat3 Association of TriC/CCT with target proteins during biosynthesis reactome 39
Stat3 BCR netpath 161
Stat3 BMP2 signaling pathway(through Smad) ( TGF-beta_BMP Diagram(MolecularVariation) ) inoh 13
Stat3 CXCR4-mediated signaling events pid 87
Stat3 Downstream signal transduction reactome 29
Stat3 EGF receptor signaling pathway panther 109
Stat3 EGFR1 netpath 475
Stat3 EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) inoh 12
Stat3 ErbB1 downstream signaling pid 105
Stat3 ErbB2/ErbB3 signaling events pid 41
Stat3 FGF signaling pathway pid 55
Stat3 Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 14
Stat3 Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 8
Stat3 Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 8
Stat3 GMCSF-mediated signaling events pid 38
Stat3 Growth hormone receptor signaling reactome 24
Stat3 IFN-gamma pathway pid 43
Stat3 IFN alpha signaling pathway(JAK1 TYK2 STAT1 STAT3) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) inoh 19
Stat3 IFN alpha signaling pathway(JAK1 TYK2 STAT3) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) inoh 18
Stat3 IL-10 signaling pathway(JAK1 TYK2 STAT3) ( IL-10 signaling(JAK1 TYK2 STAT3) ) inoh 6
Stat3 IL-23 signaling pathway(JAK2 TYK2 STAT3 STAT4) ( IL-23 signaling(JAK2 TYK2 STAT3 STAT4) ) inoh 6
Stat3 IL-6 signaling pathway(JAK1 JAK2 STAT3) ( IL-6 signaling(JAK1 JAK2 STAT3) ) inoh 6
Stat3 IL-7 netpath 28
Stat3 IL1 netpath 69
Stat3 IL12-mediated signaling events pid 62
Stat3 IL12 signaling mediated by STAT4 pid 33
Stat3 IL2-mediated signaling events pid 54
Stat3 IL2 netpath 81
Stat3 IL23-mediated signaling events pid 37
Stat3 IL27-mediated signaling events pid 26
Stat3 IL3 netpath 84
Stat3 IL4 netpath 75
Stat3 IL5 netpath 59
Stat3 IL6-mediated signaling events pid 48
Stat3 IL6 netpath 85
Stat3 IL9 netpath 24
Stat3 Inflammation mediated by chemokine and cytokine signaling pathway panther 189
Stat3 Interleukin-6 signaling reactome 11
Stat3 Interleukin signaling pathway panther 86
Stat3 JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 97
Stat3 JAK/STAT signaling pathway panther 15
Stat3 KitReceptor netpath 104
Stat3 Leptin netpath 98
Stat3 LIF signaling pathway ( LIF signaling(JAK1 JAK2 STAT3) ) inoh 10
Stat3 Neurotrophic factor-mediated Trk receptor signaling pid 63
Stat3 Notch-mediated HES/HEY network pid 48
Stat3 Notch netpath 76
Stat3 PDGF signaling pathway panther 113
Stat3 PDGFR-beta signaling pathway pid 125
Stat3 Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 178
Stat3 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation reactome 13
Stat3 Prolactin netpath 105
Stat3 RAC1 signaling pathway pid 54
Stat3 Ras Pathway panther 69
Stat3 Senescence-Associated Secretory Phenotype (SASP) reactome 108
Stat3 Signaling by cytosolic FGFR1 fusion mutants reactome 18
Stat3 Signaling by Leptin reactome 11
Stat3 Signaling by SCF-KIT reactome 37
Stat3 Signaling events mediated by HDAC Class I pid 89
Stat3 Signaling events mediated by PTP1B pid 53
Stat3 Signaling events mediated by Stem cell factor receptor (c-Kit) pid 53
Stat3 Signaling events mediated by TCPTP pid 40
Stat3 Transcriptional regulation of pluripotent stem cells reactome 28
Stat3 TSH netpath 82
Stat3 TSLP netpath 24
Stat3 Chemokine signaling pathway kegg 187
Stat3 Jak-STAT signaling pathway kegg 149
Stat3 Adipocytokine signaling pathway kegg 65
Stat3 Toxoplasmosis kegg 131
Stat3 Hepatitis C kegg 134
Stat3 Pathways in cancer kegg 321
Stat3 Pancreatic cancer kegg 70
Stat3 Acute myeloid leukemia kegg 53
Stat3 Hs_Interferon_type_I_signaling_pathways_WP585_85198 wikipathways 35
Stat3 Hs_Signaling_of_Hepatocyte_Growth_Factor_Receptor_WP313_79946 wikipathways 15
Stat3 Hs_Leptin_signaling_pathway_WP2034_89856 wikipathways 37
Stat3 Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640 wikipathways 36
Stat3 Hs_Interleukin-11_Signaling_Pathway_WP2332_79525 wikipathways 17
Stat3 Hs_PDGF_Pathway_WP2526_82681 wikipathways 12
Stat3 Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
Stat3 Hs_Dopaminergic_Neurogenesis_WP2855_87239 wikipathways 19
Stat3 Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 wikipathways 44
Stat3 Hs_Amino_Acid_metabolism_WP3925_90737 wikipathways 6
Stat3 Hs_Vitamin_B12_Metabolism_WP1533_85340 wikipathways 33
Stat3 Hs_ESC_Pluripotency_Pathways_WP3931_91005 wikipathways 13
Stat3 Hs_MicroRNAs_in_cardiomyocyte_hypertrophy_WP1544_89794 wikipathways 29
Stat3 Hs_Regulation_of_Microtubule_Cytoskeleton_WP2038_90889 wikipathways 38
Stat3 Hs_Kit_receptor_signaling_pathway_WP304_78799 wikipathways 46
Stat3 Hs_IL-5_Signaling_Pathway_WP127_78498 wikipathways 35
Stat3 Hs_IL-2_Signaling_Pathway_WP49_91243 wikipathways 33
Stat3 Hs_IL-6_signaling_pathway_WP364_89832 wikipathways 26
Stat3 Hs_RalA_downstream_regulated_genes_WP2290_79988 wikipathways 9
Stat3 Hs_IL-4_Signaling_Pathway_WP395_89828 wikipathways 41
Stat3 Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803 wikipathways 80
Stat3 Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 wikipathways 107
Stat3 Hs_IL-3_Signaling_Pathway_WP286_78583 wikipathways 35
Stat3 Hs_Notch_Signaling_Pathway_WP61_78592 wikipathways 16
Stat3 Hs_IL-9_Signaling_Pathway_WP22_79264 wikipathways 11

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs