About Enhancer

Enhancer ID: E_02_0800
Species: human
Position : chr11:355447-358949
Biosample name:
Experiment class : Low throughput
Enhancer type: Enhancer
Disease: --
Pubmed ID:  28511927
Enhancer experiment: Luciferase Reporter Assay,CRISPR/Cas9,ChIP,EMSA,3C
Enhancer experiment description: Here, through public data mining, episomal luciferase reporter assay and in vivo CRISPR-Cas9 genome editing, we identified an IFN-responsive enhancer located 35 kb upstream of IFITM3 gene promoter upregulating the IFN-induced expression of IFITM1, 2 and 3 genes. Chromatin immunoprecipitation (ChIP), electrophoretic mobility shift assay (EMSA) and luciferase reporter assay demonstrated that signal transducers and activators of transcription (STAT) 1 bound to the enhancer with the treatment of IFN and was indispensable for the enhancer activity. Furthermore, using chromosome conformation capture technique, we revealed that the IFITM1, 2 and 3 genes physically clustered together and constitutively looped to the distal enhancer through long-range interactions in both HEK293 and A549 cells, providing structural basis for coordinated regulation of IFITM1, 2 and 3 by the enhancer. Finally, we showed that in vivo truncation of the enhancer impaired IFN-induced resistance to influenza A virus (IAV) infection.

About Target gene

Target gene : IFITM1(9-27,CD225,DSPA2a,IFI17,LEU13),IFITM2(1-8D,DSPA2c),IFITM3(1-8U,DSPA2b,IP15),IFITM1(9-27,CD225,DSPA2a,IFI17,LEU13),IFITM2(1-8D,DSPA2c),IFITM3(1-8U,DSPA2b,IP15),IFITM1(9-27,CD225,DSPA2a,IFI17,LEU13),IFITM2(1-8D,DSPA2c),IFITM3(1-8U,DSPA2b,IP15)
Strong evidence: CRISPR/Cas9,3C
Less strong evidence: Luciferase Reporter Assay,EMSA
Target gene experiment description: Here, through public data mining, episomal luciferase reporter assay and in vivo CRISPR-Cas9 genome editing, we identified an IFN-responsive enhancer located 35 kb upstream of IFITM3 gene promoter upregulating the IFN-induced expression of IFITM1, 2 and 3 genes. Chromatin immunoprecipitation (ChIP), electrophoretic mobility shift assay (EMSA) and luciferase reporter assay demonstrated that signal transducers and activators of transcription (STAT) 1 bound to the enhancer with the treatment of IFN and was indispensable for the enhancer activity. Furthermore, using chromosome conformation capture technique, we revealed that the IFITM1, 2 and 3 genes physically clustered together and constitutively looped to the distal enhancer through long-range interactions in both HEK293 and A549 cells, providing structural basis for coordinated regulation of IFITM1, 2 and 3 by the enhancer.;Here, through public data mining, episomal luciferase reporter assay and in vivo CRISPR-Cas9 genome editing, we identified an IFN-responsive enhancer located 35 kb upstream of IFITM3 gene promoter upregulating the IFN-induced expression of IFITM1, 2 and 3 genes. Chromatin immunoprecipitation (ChIP), electrophoretic mobility shift assay (EMSA) and luciferase reporter assay demonstrated that signal transducers and activators of transcription (STAT) 1 bound to the enhancer with the treatment of IFN and was indispensable for the enhancer activity. Furthermore, using chromosome conformation capture technique, we revealed that the IFITM1, 2 and 3 genes physically clustered together and constitutively looped to the distal enhancer through long-range interactions in both HEK293 and A549 cells, providing structural basis for coordinated regulation of IFITM1, 2 and 3 by the enhancer.;Here, through public data mining, episomal luciferase reporter assay and in vivo CRISPR-Cas9 genome editing, we identified an IFN-responsive enhancer located 35 kb upstream of IFITM3 gene promoter upregulating the IFN-induced expression of IFITM1, 2 and 3 genes. Chromatin immunoprecipitation (ChIP), electrophoretic mobility shift assay (EMSA) and luciferase reporter assay demonstrated that signal transducers and activators of transcription (STAT) 1 bound to the enhancer with the treatment of IFN and was indispensable for the enhancer activity. Furthermore, using chromosome conformation capture technique, we revealed that the IFITM1, 2 and 3 genes physically clustered together and constitutively looped to the distal enhancer through long-range interactions in both HEK293 and A549 cells, providing structural basis for coordinated regulation of IFITM1, 2 and 3 by the enhancer.

About TF

TF name : STAT1(CANDF7,IMD31A,IMD31B,IMD31C,ISGF-3,STAT91)STAT1(CANDF7,IMD31A,IMD31B,IMD31C,ISGF-3,STAT91)STAT1(CANDF7,IMD31A,IMD31B,IMD31C,ISGF-3,STAT91)
TF experiment: ChIP,EMSA,3C
TF experiment description: Chromatin immunoprecipitation (ChIP), electrophoretic mobility shift assay (EMSA) and luciferase reporter assay demonstrated that signal transducers and activators of transcription (STAT) 1 bound to the enhancer with the treatment of IFN and was indispensable for the enhancer activity. Furthermore, using chromosome conformation capture technique, we revealed that the IFITM1, 2 and 3 genes physically clustered together and constitutively looped to the distal enhancer through long-range interactions in both HEK293 and A549 cells, providing structural basis for coordinated regulation of IFITM1, 2 and 3 by the enhancer. ;Chromatin immunoprecipitation (ChIP), electrophoretic mobility shift assay (EMSA) and luciferase reporter assay demonstrated that signal transducers and activators of transcription (STAT) 1 bound to the enhancer with the treatment of IFN and was indispensable for the enhancer activity. Furthermore, using chromosome conformation capture technique, we revealed that the IFITM1, 2 and 3 genes physically clustered together and constitutively looped to the distal enhancer through long-range interactions in both HEK293 and A549 cells, providing structural basis for coordinated regulation of IFITM1, 2 and 3 by the enhancer. ;Chromatin immunoprecipitation (ChIP), electrophoretic mobility shift assay (EMSA) and luciferase reporter assay demonstrated that signal transducers and activators of transcription (STAT) 1 bound to the enhancer with the treatment of IFN and was indispensable for the enhancer activity. Furthermore, using chromosome conformation capture technique, we revealed that the IFITM1, 2 and 3 genes physically clustered together and constitutively looped to the distal enhancer through long-range interactions in both HEK293 and A549 cells, providing structural basis for coordinated regulation of IFITM1, 2 and 3 by the enhancer.

About Function

Enhancer function : In vivo truncation of the enhancer impaired IFN-induced resistance to influenza A virus (IAV) infection.
Enhancer function experiment: RT-PCR,Western blot
Enhancer function
experiment description:		 As IFITM1, 2 and 3 are very important for host to resist infection of IAV [4], [8], we infected wild-type and E2-3-truncated HEK293 cells with IAV Puerto Rico/8/1934 (PR8) at a MOI of 0.1 for 24 h. Although IFITM1, 2 and 3 were induced by PR8 virus in both wild-type and E2-3-truncated HEK293 cells, the inductions were greatly impaired upon truncation of E2-3 (Fig. 5A and B), further confirming the regulation of IFITM1, 2 and 3 expression by the enhancer E2-3. Surprisingly, we did not observe a significant effect on the replication of IAV when enhancer E2-3 was truncated, as revealed by the mRNA and protein levels of virus NP and progeny virus titers determined by TCID50 assay (Fig. S9). Nonetheless, when we treated wild-type and E2-3-truncated HEK293 cells with IFN? respectively for 24 h before infection of PR8, NP mRNA and protein levels were found to be much higher in mutant HEK293 cells (Fig. 5C and D). Moreover, consistent with virus NP expression, the viral titers were also increased in E2-3-truncated cells (Fig. 5E), indicating that enhancer E2-3 was responsible for IFN?-induced resistance to IAV infection.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
STAT1 Angiogenesis panther 141
STAT1 BCR netpath 161
STAT1 CXCR4-mediated signaling events pid 87
STAT1 Downstream signal transduction reactome 29
STAT1 EGF receptor signaling pathway panther 109
STAT1 EGFR1 netpath 475
STAT1 EPO signaling pathway pid 33
STAT1 EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) inoh 12
STAT1 ErbB1 downstream signaling pid 105
STAT1 FGF signaling pathway pid 55
STAT1 Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 14
STAT1 Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 8
STAT1 Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 8
STAT1 Glucocorticoid receptor regulatory network pid 85
STAT1 GMCSF-mediated signaling events pid 38
STAT1 Growth hormone receptor signaling reactome 24
STAT1 IFN-gamma pathway pid 43
STAT1 IFN alpha signaling pathway((JAK1 TYK2 STAT1 STAT2) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) inoh 20
STAT1 IFN alpha signaling pathway(JAK1 TYK2 STAT1 STAT3) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) inoh 19
STAT1 IFN alpha signaling pathway(JAK1 TYK2 STAT1) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) inoh 18
STAT1 IFN gamma signaling pathway(JAK1 JAK2 STAT1) ( IFN gamma signaling(JAK1 JAK2 STAT1) ) inoh 6
STAT1 IL-5 signaling pathway(JAK1 JAK2 STAT1 STAT5) ( IL-5 signaling(JAK1 JAK2 STAT1 STAT5) ) inoh 11
STAT1 IL-7 netpath 28
STAT1 IL12-mediated signaling events pid 62
STAT1 IL2-mediated signaling events pid 54
STAT1 IL2 netpath 81
STAT1 IL23-mediated signaling events pid 37
STAT1 IL27-mediated signaling events pid 26
STAT1 IL4 netpath 75
STAT1 IL5 netpath 59
STAT1 IL6-mediated signaling events pid 48
STAT1 IL6 netpath 85
STAT1 IL9 netpath 24
STAT1 Interferon-gamma signaling pathway panther 29
STAT1 Interferon alpha/beta signaling reactome 67
STAT1 Interferon gamma signaling reactome 88
STAT1 Interleukin-6 signaling reactome 11
STAT1 Interleukin signaling pathway panther 86
STAT1 ISG15 antiviral mechanism reactome 73
STAT1 JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 97
STAT1 JAK/STAT signaling pathway panther 15
STAT1 KitReceptor netpath 104
STAT1 Leptin netpath 98
STAT1 Oxidative stress response panther 23
STAT1 PDGF signaling pathway panther 113
STAT1 PDGFR-beta signaling pathway pid 125
STAT1 Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 178
STAT1 Prolactin netpath 105
STAT1 RANKL netpath 84
STAT1 Ras Pathway panther 69
STAT1 Regulation of IFNA signaling reactome 26
STAT1 Regulation of IFNG signaling reactome 14
STAT1 SHP2 signaling pid 60
STAT1 Signaling by cytosolic FGFR1 fusion mutants reactome 18
STAT1 Signaling by SCF-KIT reactome 37
STAT1 Signaling events mediated by Stem cell factor receptor (c-Kit) pid 53
STAT1 Signaling events mediated by TCPTP pid 40
STAT1 TCR netpath 261
STAT1 TNF receptor signaling pathway pid 46
STAT1 TNFalpha netpath 274
STAT1 TSH netpath 82
STAT1 TSLP netpath 24
STAT1 Chemokine signaling pathway kegg 187
STAT1 Toll-like receptor signaling pathway kegg 100
STAT1 Jak-STAT signaling pathway kegg 149
STAT1 Leishmaniasis kegg 71
STAT1 Toxoplasmosis kegg 131
STAT1 Hepatitis C kegg 134
STAT1 Pathways in cancer kegg 321
STAT1 Pancreatic cancer kegg 70
STAT1 Hs_Interferon_type_I_signaling_pathways_WP585_85198 wikipathways 35
STAT1 Hs_Cytokines_and_Inflammatory_Response_WP530_79331 wikipathways 21
STAT1 Hs_Leptin_signaling_pathway_WP2034_89856 wikipathways 37
STAT1 Hs_Interleukin-11_Signaling_Pathway_WP2332_79525 wikipathways 17
STAT1 Hs_Endochondral_Ossification_WP474_87977 wikipathways 43
STAT1 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 wikipathways 122
STAT1 Hs_PDGF_Pathway_WP2526_82681 wikipathways 12
STAT1 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
STAT1 Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
STAT1 Hs_Integrated_Cancer_Pathway_WP1971_82939 wikipathways 33
STAT1 Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 wikipathways 44
STAT1 Hs_One_carbon_metabolism_and_related_pathways_WP3940_91096 wikipathways 10
STAT1 Hs_Kit_receptor_signaling_pathway_WP304_78799 wikipathways 46
STAT1 Hs_IL-5_Signaling_Pathway_WP127_78498 wikipathways 35
STAT1 Hs_IL-2_Signaling_Pathway_WP49_91243 wikipathways 33
STAT1 Hs_IL-6_signaling_pathway_WP364_89832 wikipathways 26
STAT1 Hs_Prolactin_Signaling_Pathway_WP2037_90015 wikipathways 52
STAT1 Hs_IL-4_Signaling_Pathway_WP395_89828 wikipathways 41
STAT1 Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803 wikipathways 80
STAT1 Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 wikipathways 107
STAT1 Hs_IL-9_Signaling_Pathway_WP22_79264 wikipathways 11
STAT1 Hs_Insulin_signalling_in_adipocytes_(diabetic_condition)_WP3635_86059 wikipathways 6
STAT1 Hs_Insulin_signalling_in_adipocytes_(normal_condition)_WP3634_86060 wikipathways 6
STAT1 Angiogenesis panther 141
STAT1 BCR netpath 161
STAT1 CXCR4-mediated signaling events pid 87
STAT1 Downstream signal transduction reactome 29
STAT1 EGF receptor signaling pathway panther 109
STAT1 EGFR1 netpath 475
STAT1 EPO signaling pathway pid 33
STAT1 EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) inoh 12
STAT1 ErbB1 downstream signaling pid 105
STAT1 FGF signaling pathway pid 55
STAT1 Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 14
STAT1 Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 8
STAT1 Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 8
STAT1 Glucocorticoid receptor regulatory network pid 85
STAT1 GMCSF-mediated signaling events pid 38
STAT1 Growth hormone receptor signaling reactome 24
STAT1 IFN-gamma pathway pid 43
STAT1 IFN alpha signaling pathway((JAK1 TYK2 STAT1 STAT2) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) inoh 20
STAT1 IFN alpha signaling pathway(JAK1 TYK2 STAT1 STAT3) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) inoh 19
STAT1 IFN alpha signaling pathway(JAK1 TYK2 STAT1) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) inoh 18
STAT1 IFN gamma signaling pathway(JAK1 JAK2 STAT1) ( IFN gamma signaling(JAK1 JAK2 STAT1) ) inoh 6
STAT1 IL-5 signaling pathway(JAK1 JAK2 STAT1 STAT5) ( IL-5 signaling(JAK1 JAK2 STAT1 STAT5) ) inoh 11
STAT1 IL-7 netpath 28
STAT1 IL12-mediated signaling events pid 62
STAT1 IL2-mediated signaling events pid 54
STAT1 IL2 netpath 81
STAT1 IL23-mediated signaling events pid 37
STAT1 IL27-mediated signaling events pid 26
STAT1 IL4 netpath 75
STAT1 IL5 netpath 59
STAT1 IL6-mediated signaling events pid 48
STAT1 IL6 netpath 85
STAT1 IL9 netpath 24
STAT1 Interferon-gamma signaling pathway panther 29
STAT1 Interferon alpha/beta signaling reactome 67
STAT1 Interferon gamma signaling reactome 88
STAT1 Interleukin-6 signaling reactome 11
STAT1 Interleukin signaling pathway panther 86
STAT1 ISG15 antiviral mechanism reactome 73
STAT1 JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 97
STAT1 JAK/STAT signaling pathway panther 15
STAT1 KitReceptor netpath 104
STAT1 Leptin netpath 98
STAT1 Oxidative stress response panther 23
STAT1 PDGF signaling pathway panther 113
STAT1 PDGFR-beta signaling pathway pid 125
STAT1 Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 178
STAT1 Prolactin netpath 105
STAT1 RANKL netpath 84
STAT1 Ras Pathway panther 69
STAT1 Regulation of IFNA signaling reactome 26
STAT1 Regulation of IFNG signaling reactome 14
STAT1 SHP2 signaling pid 60
STAT1 Signaling by cytosolic FGFR1 fusion mutants reactome 18
STAT1 Signaling by SCF-KIT reactome 37
STAT1 Signaling events mediated by Stem cell factor receptor (c-Kit) pid 53
STAT1 Signaling events mediated by TCPTP pid 40
STAT1 TCR netpath 261
STAT1 TNF receptor signaling pathway pid 46
STAT1 TNFalpha netpath 274
STAT1 TSH netpath 82
STAT1 TSLP netpath 24
STAT1 Chemokine signaling pathway kegg 187
STAT1 Toll-like receptor signaling pathway kegg 100
STAT1 Jak-STAT signaling pathway kegg 149
STAT1 Leishmaniasis kegg 71
STAT1 Toxoplasmosis kegg 131
STAT1 Hepatitis C kegg 134
STAT1 Pathways in cancer kegg 321
STAT1 Pancreatic cancer kegg 70
STAT1 Hs_Interferon_type_I_signaling_pathways_WP585_85198 wikipathways 35
STAT1 Hs_Cytokines_and_Inflammatory_Response_WP530_79331 wikipathways 21
STAT1 Hs_Leptin_signaling_pathway_WP2034_89856 wikipathways 37
STAT1 Hs_Interleukin-11_Signaling_Pathway_WP2332_79525 wikipathways 17
STAT1 Hs_Endochondral_Ossification_WP474_87977 wikipathways 43
STAT1 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 wikipathways 122
STAT1 Hs_PDGF_Pathway_WP2526_82681 wikipathways 12
STAT1 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
STAT1 Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
STAT1 Hs_Integrated_Cancer_Pathway_WP1971_82939 wikipathways 33
STAT1 Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 wikipathways 44
STAT1 Hs_One_carbon_metabolism_and_related_pathways_WP3940_91096 wikipathways 10
STAT1 Hs_Kit_receptor_signaling_pathway_WP304_78799 wikipathways 46
STAT1 Hs_IL-5_Signaling_Pathway_WP127_78498 wikipathways 35
STAT1 Hs_IL-2_Signaling_Pathway_WP49_91243 wikipathways 33
STAT1 Hs_IL-6_signaling_pathway_WP364_89832 wikipathways 26
STAT1 Hs_Prolactin_Signaling_Pathway_WP2037_90015 wikipathways 52
STAT1 Hs_IL-4_Signaling_Pathway_WP395_89828 wikipathways 41
STAT1 Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803 wikipathways 80
STAT1 Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 wikipathways 107
STAT1 Hs_IL-9_Signaling_Pathway_WP22_79264 wikipathways 11
STAT1 Hs_Insulin_signalling_in_adipocytes_(diabetic_condition)_WP3635_86059 wikipathways 6
STAT1 Hs_Insulin_signalling_in_adipocytes_(normal_condition)_WP3634_86060 wikipathways 6
STAT1 Angiogenesis panther 141
STAT1 BCR netpath 161
STAT1 CXCR4-mediated signaling events pid 87
STAT1 Downstream signal transduction reactome 29
STAT1 EGF receptor signaling pathway panther 109
STAT1 EGFR1 netpath 475
STAT1 EPO signaling pathway pid 33
STAT1 EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) inoh 12
STAT1 ErbB1 downstream signaling pid 105
STAT1 FGF signaling pathway pid 55
STAT1 Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 14
STAT1 Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 8
STAT1 Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 8
STAT1 Glucocorticoid receptor regulatory network pid 85
STAT1 GMCSF-mediated signaling events pid 38
STAT1 Growth hormone receptor signaling reactome 24
STAT1 IFN-gamma pathway pid 43
STAT1 IFN alpha signaling pathway((JAK1 TYK2 STAT1 STAT2) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) inoh 20
STAT1 IFN alpha signaling pathway(JAK1 TYK2 STAT1 STAT3) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) inoh 19
STAT1 IFN alpha signaling pathway(JAK1 TYK2 STAT1) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) inoh 18
STAT1 IFN gamma signaling pathway(JAK1 JAK2 STAT1) ( IFN gamma signaling(JAK1 JAK2 STAT1) ) inoh 6
STAT1 IL-5 signaling pathway(JAK1 JAK2 STAT1 STAT5) ( IL-5 signaling(JAK1 JAK2 STAT1 STAT5) ) inoh 11
STAT1 IL-7 netpath 28
STAT1 IL12-mediated signaling events pid 62
STAT1 IL2-mediated signaling events pid 54
STAT1 IL2 netpath 81
STAT1 IL23-mediated signaling events pid 37
STAT1 IL27-mediated signaling events pid 26
STAT1 IL4 netpath 75
STAT1 IL5 netpath 59
STAT1 IL6-mediated signaling events pid 48
STAT1 IL6 netpath 85
STAT1 IL9 netpath 24
STAT1 Interferon-gamma signaling pathway panther 29
STAT1 Interferon alpha/beta signaling reactome 67
STAT1 Interferon gamma signaling reactome 88
STAT1 Interleukin-6 signaling reactome 11
STAT1 Interleukin signaling pathway panther 86
STAT1 ISG15 antiviral mechanism reactome 73
STAT1 JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 97
STAT1 JAK/STAT signaling pathway panther 15
STAT1 KitReceptor netpath 104
STAT1 Leptin netpath 98
STAT1 Oxidative stress response panther 23
STAT1 PDGF signaling pathway panther 113
STAT1 PDGFR-beta signaling pathway pid 125
STAT1 Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 178
STAT1 Prolactin netpath 105
STAT1 RANKL netpath 84
STAT1 Ras Pathway panther 69
STAT1 Regulation of IFNA signaling reactome 26
STAT1 Regulation of IFNG signaling reactome 14
STAT1 SHP2 signaling pid 60
STAT1 Signaling by cytosolic FGFR1 fusion mutants reactome 18
STAT1 Signaling by SCF-KIT reactome 37
STAT1 Signaling events mediated by Stem cell factor receptor (c-Kit) pid 53
STAT1 Signaling events mediated by TCPTP pid 40
STAT1 TCR netpath 261
STAT1 TNF receptor signaling pathway pid 46
STAT1 TNFalpha netpath 274
STAT1 TSH netpath 82
STAT1 TSLP netpath 24
STAT1 Chemokine signaling pathway kegg 187
STAT1 Toll-like receptor signaling pathway kegg 100
STAT1 Jak-STAT signaling pathway kegg 149
STAT1 Leishmaniasis kegg 71
STAT1 Toxoplasmosis kegg 131
STAT1 Hepatitis C kegg 134
STAT1 Pathways in cancer kegg 321
STAT1 Pancreatic cancer kegg 70
STAT1 Hs_Interferon_type_I_signaling_pathways_WP585_85198 wikipathways 35
STAT1 Hs_Cytokines_and_Inflammatory_Response_WP530_79331 wikipathways 21
STAT1 Hs_Leptin_signaling_pathway_WP2034_89856 wikipathways 37
STAT1 Hs_Interleukin-11_Signaling_Pathway_WP2332_79525 wikipathways 17
STAT1 Hs_Endochondral_Ossification_WP474_87977 wikipathways 43
STAT1 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 wikipathways 122
STAT1 Hs_PDGF_Pathway_WP2526_82681 wikipathways 12
STAT1 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
STAT1 Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
STAT1 Hs_Integrated_Cancer_Pathway_WP1971_82939 wikipathways 33
STAT1 Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 wikipathways 44
STAT1 Hs_One_carbon_metabolism_and_related_pathways_WP3940_91096 wikipathways 10
STAT1 Hs_Kit_receptor_signaling_pathway_WP304_78799 wikipathways 46
STAT1 Hs_IL-5_Signaling_Pathway_WP127_78498 wikipathways 35
STAT1 Hs_IL-2_Signaling_Pathway_WP49_91243 wikipathways 33
STAT1 Hs_IL-6_signaling_pathway_WP364_89832 wikipathways 26
STAT1 Hs_Prolactin_Signaling_Pathway_WP2037_90015 wikipathways 52
STAT1 Hs_IL-4_Signaling_Pathway_WP395_89828 wikipathways 41
STAT1 Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803 wikipathways 80
STAT1 Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 wikipathways 107
STAT1 Hs_IL-9_Signaling_Pathway_WP22_79264 wikipathways 11
STAT1 Hs_Insulin_signalling_in_adipocytes_(diabetic_condition)_WP3635_86059 wikipathways 6
STAT1 Hs_Insulin_signalling_in_adipocytes_(normal_condition)_WP3634_86060 wikipathways 6

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs