About Enhancer

Enhancer ID: E_02_0801
Species: human
Position : chr11:17666830-17677080
Biosample name:
Experiment class : Low+High throughput
Enhancer type: Super-Enhancer
Disease: Alveolar rhabdomyosarcoma
Pubmed ID:  28446439
Enhancer experiment: ChIP-seq,4C,Luciferase Reporter Assay
Enhancer experiment description: We found PAX3-FOXO1 most frequently occupied the strong Enhancer chromatin state , exemplified by known PAX3-FOXO1 target FGFR4 and oncogenes MYC, ALK and MET

About Target gene

Target gene : MYOD1(MYF3,MYOD,PUM,bHLHc1),MYOD1(MYF3,MYOD,PUM,bHLHc1)
Strong evidence: 4C
Less strong evidence: ChIP-seq,Luciferase Reporter Assay
Target gene experiment description: We found PAX3-FOXO1 most frequently occupied the strong Enhancer chromatin state , exemplified by known PAX3-FOXO1 target FGFR4 and oncogenes MYC, ALK and MET;We found PAX3-FOXO1 most frequently occupied the strong Enhancer chromatin state , exemplified by known PAX3-FOXO1 target FGFR4 and oncogenes MYC, ALK and MET

About TF

TF name : PAX3(CDHS,HUP2,WS1,WS3)FOXO1(FKH1,FKHRA,FOXO1)PAX3(CDHS,HUP2,WS1,WS3)FOXO1(FKH1,FKHRA,FOXO1)
TF experiment: ChIP-qPCR,ChIP-seq
TF experiment description: To gain insight into the epigenetic consequences of PAX3-FOXO1, we mapped the landscape of active and repressive histone marks by sequencing DNA enriched by chromatin immunoprecipitation (ChIP-seq) from a patient derived fusion positive FP-RMS cell line RH4. ;To gain insight into the epigenetic consequences of PAX3-FOXO1, we mapped the landscape of active and repressive histone marks by sequencing DNA enriched by chromatin immunoprecipitation (ChIP-seq) from a patient derived fusion positive FP-RMS cell line RH4.

About Function

Enhancer function : --
Enhancer function experiment: --
Enhancer function
experiment description:		 --

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
PAX3 HATs acetylate histones reactome 142
PAX3 Regulation of retinoblastoma protein pid 67
PAX3 Hs_Neural_Crest_Differentiation_WP2064_79263 wikipathways 40
PAX3 Hs_Ectoderm_Differentiation_WP2858_89329 wikipathways 56
FOXO1 AKT phosphorylates targets in the nucleus reactome 9
FOXO1 AndrogenReceptor netpath 167
FOXO1 Angiopoietin receptor Tie2-mediated signaling pid 50
FOXO1 BCR netpath 161
FOXO1 Class I PI3K signaling events mediated by Akt pid 35
FOXO1 Constitutive Signaling by AKT1 E17K in Cancer reactome 25
FOXO1 CXCR4-mediated signaling events pid 87
FOXO1 EGFR1 netpath 475
FOXO1 FoxO family signaling pid 50
FOXO1 FSH netpath 44
FOXO1 IL-7 netpath 28
FOXO1 IL3 netpath 84
FOXO1 IL6-mediated signaling events pid 48
FOXO1 IL6 netpath 85
FOXO1 Insulin/IGF pathway-protein kinase B signaling cascade panther 22
FOXO1 Leptin netpath 98
FOXO1 MAPK6/MAPK4 signaling reactome 90
FOXO1 Negative regulation of gene expression ( Insulin receptor signaling (D. melanogaster) ) inoh 7
FOXO1 Negative regulation of gene expression ( Insulin receptor signaling (Mammal) ) inoh 7
FOXO1 PI3 kinase pathway panther 38
FOXO1 Regulation of Androgen receptor activity pid 54
FOXO1 Regulation of gene expression in beta cells reactome 17
FOXO1 Regulation of nuclear SMAD2/3 signaling pid 82
FOXO1 Signaling events mediated by HDAC Class III pid 41
FOXO1 TGF_beta_Receptor netpath 220
FOXO1 TNFalpha netpath 274
FOXO1 Insulin signaling pathway kegg 134
FOXO1 Pathways in cancer kegg 321
FOXO1 Prostate cancer kegg 85
FOXO1 Hs_ErbB_Signaling_Pathway_WP673_91869 wikipathways 37
FOXO1 Hs_Angiopoietin_Like_Protein_8_Regulatory_Pathway_WP3915_90629 wikipathways 9
FOXO1 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 wikipathways 122
FOXO1 Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
FOXO1 Hs_Rac1-Pak1-p38-MMP-2_pathway_WP3303_87628 wikipathways 32
FOXO1 Hs_Energy_Metabolism_WP1541_91584 wikipathways 13
FOXO1 Hs_Transcription_factor_regulation_in_adipogenesis_WP3599_88581 wikipathways 9
FOXO1 Hs_NAD_metabolism,_sirtuins_and_aging_WP3630_88178 wikipathways 8
FOXO1 Hs_AGE-RAGE_pathway_WP2324_89798 wikipathways 27
FOXO1 Hs_Follicle_Stimulating_Hormone_(FSH)_signaling_pathway_WP2035_86080 wikipathways 20
PAX3 HATs acetylate histones reactome 142
PAX3 Regulation of retinoblastoma protein pid 67
PAX3 Hs_Neural_Crest_Differentiation_WP2064_79263 wikipathways 40
PAX3 Hs_Ectoderm_Differentiation_WP2858_89329 wikipathways 56
FOXO1 AKT phosphorylates targets in the nucleus reactome 9
FOXO1 AndrogenReceptor netpath 167
FOXO1 Angiopoietin receptor Tie2-mediated signaling pid 50
FOXO1 BCR netpath 161
FOXO1 Class I PI3K signaling events mediated by Akt pid 35
FOXO1 Constitutive Signaling by AKT1 E17K in Cancer reactome 25
FOXO1 CXCR4-mediated signaling events pid 87
FOXO1 EGFR1 netpath 475
FOXO1 FoxO family signaling pid 50
FOXO1 FSH netpath 44
FOXO1 IL-7 netpath 28
FOXO1 IL3 netpath 84
FOXO1 IL6-mediated signaling events pid 48
FOXO1 IL6 netpath 85
FOXO1 Insulin/IGF pathway-protein kinase B signaling cascade panther 22
FOXO1 Leptin netpath 98
FOXO1 MAPK6/MAPK4 signaling reactome 90
FOXO1 Negative regulation of gene expression ( Insulin receptor signaling (D. melanogaster) ) inoh 7
FOXO1 Negative regulation of gene expression ( Insulin receptor signaling (Mammal) ) inoh 7
FOXO1 PI3 kinase pathway panther 38
FOXO1 Regulation of Androgen receptor activity pid 54
FOXO1 Regulation of gene expression in beta cells reactome 17
FOXO1 Regulation of nuclear SMAD2/3 signaling pid 82
FOXO1 Signaling events mediated by HDAC Class III pid 41
FOXO1 TGF_beta_Receptor netpath 220
FOXO1 TNFalpha netpath 274
FOXO1 Insulin signaling pathway kegg 134
FOXO1 Pathways in cancer kegg 321
FOXO1 Prostate cancer kegg 85
FOXO1 Hs_ErbB_Signaling_Pathway_WP673_91869 wikipathways 37
FOXO1 Hs_Angiopoietin_Like_Protein_8_Regulatory_Pathway_WP3915_90629 wikipathways 9
FOXO1 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 wikipathways 122
FOXO1 Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
FOXO1 Hs_Rac1-Pak1-p38-MMP-2_pathway_WP3303_87628 wikipathways 32
FOXO1 Hs_Energy_Metabolism_WP1541_91584 wikipathways 13
FOXO1 Hs_Transcription_factor_regulation_in_adipogenesis_WP3599_88581 wikipathways 9
FOXO1 Hs_NAD_metabolism,_sirtuins_and_aging_WP3630_88178 wikipathways 8
FOXO1 Hs_AGE-RAGE_pathway_WP2324_89798 wikipathways 27
FOXO1 Hs_Follicle_Stimulating_Hormone_(FSH)_signaling_pathway_WP2035_86080 wikipathways 20

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs