About Enhancer
| Enhancer ID: | E_02_0807 |
| Species: | human |
| Position : | chr3:181572712-181574712   |
| Biosample name: | |
| Experiment class : | Low throughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 28244015 |
| Enhancer experiment: | ChIP,qPCR |
| Enhancer experiment description: | To determine whether BPA-activated pCREB directly regulates SOX2 , ChIP was performed after a 5-minute treatment with either E2 or BPA. pCREB was enriched at an Enhancer region located 143 kilobases downstream of the SOX2 coding region only after BPA treatment (Figure 6), which correlates with gene expression |
About Target gene
| Target gene : | SOX2(ANOP3,MCOPS3) |
| Strong evidence: | -- |
| Less strong evidence: | ChIP,qPCR |
| Target gene experiment description: | To determine whether BPA-activated pCREB directly regulates SOX2 , ChIP was performed after a 5-minute treatment with either E2 or BPA. pCREB was enriched at an Enhancer region located 143 kilobases downstream of the SOX2 coding region only after BPA treatment (Figure 6), which correlates with gene expression |
About TF
| TF name : | DST(BP240,BPA,BPAG1,CATX-15,CATX15,D6S1101,DMH,DT,EBSB2,HSAN6,MACF2) |
| TF experiment: | ChIP |
| TF experiment description: | To determine whether BPA-activated pCREB directly regulates SOX2, ChIP was performed after a 5-minute treatment with either E2 or BPA. pCREB was enriched at an Enhancer region located 143 kilobases downstream of the SOX2 coding region only after BPA treatment (Figure 6), which correlates with gene expression. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| DST | Alpha6Beta4Integrin | netpath | 74 |
| DST | Assembly of collagen fibrils and other multimeric structures | reactome | 44 |
| DST | Type I hemidesmosome assembly | reactome | 9 |
| DST | Validated transcriptional targets of TAp63 isoforms | pid | 54 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene