About Enhancer
| Enhancer ID: | E_02_0812 |
| Species: | human |
| Position : | chr2:105072843-105076843   |
| Biosample name: | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer |
| Disease: | Genitourinary defects |
| Pubmed ID: | 28087634 |
| Enhancer experiment: | ChIP-seq,DNaseI-seq |
| Enhancer experiment description: | H3K27ac ChIP-seq on E13.5 Sertoli cells identified >28,000 H3K27ac peaks, ?70% of which overlapped a DHS in our E13.5 Sertoli cell dataset (Fig. 3A, Fig. S4).H3K27ac-positive DHSs, which are indicative of active enhancers, were significantly enriched specifically in neighboring Sertoli cell-expressed genes (Fig. 3D), as expected. |
About Target gene
| Target gene : | Wt1 (AWT1,GUD,NPHS4,WAGR,WIT-2,WT33),Wt1 (AWT1,GUD,NPHS4,WAGR,WIT-2,WT33) |
| Strong evidence: | -- |
| Less strong evidence: | ChIP-seq,DNaseI-seq |
| Target gene experiment description: | To demonstrate this, we performed a transient transgenic assay with a putative active enhancer of the Wt1 gene (Fig. 5A,B).We identified a DHS peak located 50?kb upstream of Wt1 that was unique to E13.5 and E15.5 Sertoli cells compared with the other cell types we examined, and marked by H3K27ac, suggesting that it functions as an active enhancer.;To demonstrate this, we performed a transient transgenic assay with a putative active enhancer of the Wt1 gene (Fig. 5A,B).We identified a DHS peak located 50?kb upstream of Wt1 that was unique to E13.5 and E15.5 Sertoli cells compared with the other cell types we examined, and marked by H3K27ac, suggesting that it functions as an active enhancer. |
About TF
| TF name : | ---- |
| TF experiment: | -- |
| TF experiment description: | --;-- |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene