About Enhancer
| Enhancer ID: | E_02_0830 |
| Species: | mouse |
| Position : | chr14:61121917-61123917   |
| Biosample name: | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 26884396 |
| Enhancer experiment: | ChIP-seq |
| Enhancer experiment description: | ChIP-seq was performed on 17 week fetal kidneys and E16.5 mouse kidneys to assess chromatin marks associated with active genes and enhancers (H3K27ac) and transcriptionally silenced chromatin (H3K27me3). Similarly, the human SIX1 locus was bound by SIX2 at multiple conserved elements and displayed prominent H3K27ac throughout the gene body and the SIX2-bound regions (Fig. 3A). |
About Target gene
| Target gene : | SIX1(BOS3,DFNA23,TIP39),SIX1(BOS3,DFNA23,TIP39) |
| Strong evidence: | -- |
| Less strong evidence: | RNA-seq |
| Target gene experiment description: | Using RNA-seq data from nephron progenitors, we compared expression of genes between human and mouse and identified genes that were >5-fold enriched in either species and were also a species-specific target (Fig. 2E, right panel,highlighted genes). SIX1 is expressed in the human ITGA8+progenitors, but not in mouse nephron progenitors, identifying SIX1 as a human specific target on the basis of both cis-interactions around the SIX1 gene and active SIX1 expression (right panelFig. 2E; Table S3).;Using RNA-seq data from nephron progenitors, we compared expression of genes between human and mouse and identified genes that were >5-fold enriched in either species and were also a species-specific target (Fig. 2E, right panel,highlighted genes). SIX1 is expressed in the human ITGA8+progenitors, but not in mouse nephron progenitors, identifying SIX1 as a human specific target on the basis of both cis-interactions around the SIX1 gene and active SIX1 expression (right panelFig. 2E; Table S3). |
About TF
| TF name : | SIX2(SIX2)SIX2(SIX2) |
| TF experiment: | ChIP |
| TF experiment description: | The differing number of peaks was due to lower levels of SIX2 ChIP enrichment in the second replicate (Fig. S1C). Examination of SIX2 binding near MEOX1 and WT1 highlighted the similar binding profiles for SIX2 replicates(Fig. 1B).;The differing number of peaks was due to lower levels of SIX2 ChIP enrichment in the second replicate (Fig. S1C). Examination of SIX2 binding near MEOX1 and WT1 highlighted the similar binding profiles for SIX2 replicates(Fig. 1B). |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene