About Enhancer

Enhancer ID: E_02_0845
Species: mouse
Position : chr12:85433906-85439068
Biosample name:
Experiment class : Low+High throughput
Enhancer type: Enhancer
Disease: --
Pubmed ID:  26595656
Enhancer experiment: ChIP-seq,Luciferase Reporter Assay
Enhancer experiment description: These enhancers, which we identified in primary cultures of mouse cortical neurons, appear to be active in the intact brain throughout development, as all of them were tightly aligned with the chroma_x0002_tin immunoprecipitation (ChIP)-seq peaks of the active enhancer marker, acetylated H3K27 (H3K27ac)(Supplementary Fig. 1).

About Target gene

Target gene : Fos(D12Rfj1,c-fos,cFos),Fos(D12Rfj1,c-fos,cFos),Fos(D12Rfj1,c-fos,cFos),Fos(D12Rfj1,c-fos,cFos),Fos(D12Rfj1,c-fos,cFos),Fos(D12Rfj1,c-fos,cFos),Fos(D12Rfj1,c-fos,cFos),Fos(D12Rfj1,c-fos,cFos),Fos(D12Rfj1,c-fos,cFos)
Strong evidence: 3C
Less strong evidence: --
Target gene experiment description: Characterizing individual c-fos Enhancers by chromosome-conformation capture (3C) analysis and an Enhancer reporter assay, we have corroborated the idea that eRNA is a reliable marker for identifying activated Enhancers.;Characterizing individual c-fos Enhancers by chromosome-conformation capture (3C) analysis and an Enhancer reporter assay, we have corroborated the idea that eRNA is a reliable marker for identifying activated Enhancers.;Characterizing individual c-fos Enhancers by chromosome-conformation capture (3C) analysis and an Enhancer reporter assay, we have corroborated the idea that eRNA is a reliable marker for identifying activated Enhancers.;Characterizing individual c-fos Enhancers by chromosome-conformation capture (3C) analysis and an Enhancer reporter assay, we have corroborated the idea that eRNA is a reliable marker for identifying activated Enhancers.;Characterizing individual c-fos Enhancers by chromosome-conformation capture (3C) analysis and an Enhancer reporter assay, we have corroborated the idea that eRNA is a reliable marker for identifying activated Enhancers.;Characterizing individual c-fos Enhancers by chromosome-conformation capture (3C) analysis and an Enhancer reporter assay, we have corroborated the idea that eRNA is a reliable marker for identifying activated Enhancers.;Characterizing individual c-fos Enhancers by chromosome-conformation capture (3C) analysis and an Enhancer reporter assay, we have corroborated the idea that eRNA is a reliable marker for identifying activated Enhancers.;Characterizing individual c-fos Enhancers by chromosome-conformation capture (3C) analysis and an Enhancer reporter assay, we have corroborated the idea that eRNA is a reliable marker for identifying activated Enhancers.;Characterizing individual c-fos Enhancers by chromosome-conformation capture (3C) analysis and an Enhancer reporter assay, we have corroborated the idea that eRNA is a reliable marker for identifying activated Enhancers.

About TF

TF name : Creb(Creb)srf(AW049942,AW240594)Mef2a(A430079H05Rik)Mef2d(C80750)Mef2c(5430401D19Rik,9930028G15Rik,AV011172,Mef2)Npas4(LE-PAS,Nxf)Creb(Creb)srf(AW049942,AW240594)Mef2a(A430079H05Rik)Mef2d(C80750)Mef2c(5430401D19Rik,9930028G15Rik,AV011172,Mef2)Npas4(LE-PAS,Nxf)Creb(Creb)srf(AW049942,AW240594)Mef2a(A430079H05Rik)Mef2d(C80750)Mef2c(5430401D19Rik,9930028G15Rik,AV011172,Mef2)Npas4(LE-PAS,Nxf)Creb(Creb)srf(AW049942,AW240594)Mef2a(A430079H05Rik)Mef2d(C80750)Mef2c(5430401D19Rik,9930028G15Rik,AV011172,Mef2)Npas4(LE-PAS,Nxf)Creb(Creb)srf(AW049942,AW240594)Mef2a(A430079H05Rik)Mef2d(C80750)Mef2c(5430401D19Rik,9930028G15Rik,AV011172,Mef2)Npas4(LE-PAS,Nxf)Creb(Creb)srf(AW049942,AW240594)Mef2a(A430079H05Rik)Mef2d(C80750)Mef2c(5430401D19Rik,9930028G15Rik,AV011172,Mef2)Npas4(LE-PAS,Nxf)Creb(Creb)srf(AW049942,AW240594)Mef2a(A430079H05Rik)Mef2d(C80750)Mef2c(5430401D19Rik,9930028G15Rik,AV011172,Mef2)Npas4(LE-PAS,Nxf)Creb(Creb)srf(AW049942,AW240594)Mef2a(A430079H05Rik)Mef2d(C80750)Mef2c(5430401D19Rik,9930028G15Rik,AV011172,Mef2)Npas4(LE-PAS,Nxf)Creb(Creb)srf(AW049942,AW240594)Mef2a(A430079H05Rik)Mef2d(C80750)Mef2c(5430401D19Rik,9930028G15Rik,AV011172,Mef2)Npas4(LE-PAS,Nxf)
TF experiment: ChIP-seq
TF experiment description: ChIP-_x0002_seq analysis has revealed that the c-fos promoter and enhancers were bound by different combinations of several activity-regulated TFs6 (Supplementary Fig. 1).Knockdown of CREB, MEF2A and NPAS4 significantly impaired c-fos induction by Cl-mediated membrane depolarization (Fig. 4a and Supplementary Fig. 4). Although knockdown of MEF2 family members MEF2D and MEF2C showed a slight decrease in c-fos expression, it was not significant and had a weaker impact than MEF2A knockdown. The decrease in c-fos expression was paralleled with little effect on eRNA transcription (Supplementary Fig. 5).;ChIP-_x0002_seq analysis has revealed that the c-fos promoter and enhancers were bound by different combinations of several activity-regulated TFs6 (Supplementary Fig. 1).Knockdown of CREB, MEF2A and NPAS4 significantly impaired c-fos induction by Cl-mediated membrane depolarization (Fig. 4a and Supplementary Fig. 4). Although knockdown of MEF2 family members MEF2D and MEF2C showed a slight decrease in c-fos expression, it was not significant and had a weaker impact than MEF2A knockdown. The decrease in c-fos expression was paralleled with little effect on eRNA transcription (Supplementary Fig. 5).;ChIP-_x0002_seq analysis has revealed that the c-fos promoter and enhancers were bound by different combinations of several activity-regulated TFs6 (Supplementary Fig. 1).Knockdown of CREB, MEF2A and NPAS4 significantly impaired c-fos induction by Cl-mediated membrane depolarization (Fig. 4a and Supplementary Fig. 4). Although knockdown of MEF2 family members MEF2D and MEF2C showed a slight decrease in c-fos expression, it was not significant and had a weaker impact than MEF2A knockdown. The decrease in c-fos expression was paralleled with little effect on eRNA transcription (Supplementary Fig. 5).;ChIP-_x0002_seq analysis has revealed that the c-fos promoter and enhancers were bound by different combinations of several activity-regulated TFs6 (Supplementary Fig. 1).Knockdown of CREB, MEF2A and NPAS4 significantly impaired c-fos induction by Cl-mediated membrane depolarization (Fig. 4a and Supplementary Fig. 4). Although knockdown of MEF2 family members MEF2D and MEF2C showed a slight decrease in c-fos expression, it was not significant and had a weaker impact than MEF2A knockdown. The decrease in c-fos expression was paralleled with little effect on eRNA transcription (Supplementary Fig. 5).;ChIP-_x0002_seq analysis has revealed that the c-fos promoter and enhancers were bound by different combinations of several activity-regulated TFs6 (Supplementary Fig. 1).Knockdown of CREB, MEF2A and NPAS4 significantly impaired c-fos induction by Cl-mediated membrane depolarization (Fig. 4a and Supplementary Fig. 4). Although knockdown of MEF2 family members MEF2D and MEF2C showed a slight decrease in c-fos expression, it was not significant and had a weaker impact than MEF2A knockdown. The decrease in c-fos expression was paralleled with little effect on eRNA transcription (Supplementary Fig. 5).;ChIP-_x0002_seq analysis has revealed that the c-fos promoter and enhancers were bound by different combinations of several activity-regulated TFs6 (Supplementary Fig. 1).Knockdown of CREB, MEF2A and NPAS4 significantly impaired c-fos induction by Cl-mediated membrane depolarization (Fig. 4a and Supplementary Fig. 4). Although knockdown of MEF2 family members MEF2D and MEF2C showed a slight decrease in c-fos expression, it was not significant and had a weaker impact than MEF2A knockdown. The decrease in c-fos expression was paralleled with little effect on eRNA transcription (Supplementary Fig. 5).;ChIP-_x0002_seq analysis has revealed that the c-fos promoter and enhancers were bound by different combinations of several activity-regulated TFs6 (Supplementary Fig. 1).Knockdown of CREB, MEF2A and NPAS4 significantly impaired c-fos induction by Cl-mediated membrane depolarization (Fig. 4a and Supplementary Fig. 4). Although knockdown of MEF2 family members MEF2D and MEF2C showed a slight decrease in c-fos expression, it was not significant and had a weaker impact than MEF2A knockdown. The decrease in c-fos expression was paralleled with little effect on eRNA transcription (Supplementary Fig. 5).;ChIP-_x0002_seq analysis has revealed that the c-fos promoter and enhancers were bound by different combinations of several activity-regulated TFs6 (Supplementary Fig. 1).Knockdown of CREB, MEF2A and NPAS4 significantly impaired c-fos induction by Cl-mediated membrane depolarization (Fig. 4a and Supplementary Fig. 4). Although knockdown of MEF2 family members MEF2D and MEF2C showed a slight decrease in c-fos expression, it was not significant and had a weaker impact than MEF2A knockdown. The decrease in c-fos expression was paralleled with little effect on eRNA transcription (Supplementary Fig. 5).;ChIP-_x0002_seq analysis has revealed that the c-fos promoter and enhancers were bound by different combinations of several activity-regulated TFs6 (Supplementary Fig. 1).Knockdown of CREB, MEF2A and NPAS4 significantly impaired c-fos induction by Cl-mediated membrane depolarization (Fig. 4a and Supplementary Fig. 4). Although knockdown of MEF2 family members MEF2D and MEF2C showed a slight decrease in c-fos expression, it was not significant and had a weaker impact than MEF2A knockdown. The decrease in c-fos expression was paralleled with little effect on eRNA transcription (Supplementary Fig. 5).

About Function

Enhancer function : These results demonstrate that the combinatorial activation of the c-fosenhancers enables the c-fos gene to be broadly responsive to various signaling pathways.
Enhancer function experiment: CRISPRi,RT-qPCR
Enhancer function
experiment description:		 We also evaluated the functionality of individual enhancers in their native context by targeted transcription silencing via CRISPR interference (CRISPRi). Using eRNA as a proxy for enhancer activity, we found that distinc_x0002_tive subsets of the c-fos enhancers are activated in the intact brain following chemically induced seizure or light stimulation.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
srf Coregulation of Androgen receptor activity pid 61
srf ErbB1 downstream signaling pid 105
srf Interleukin signaling pathway panther 86
srf p38 MAPK pathway panther 31
srf p38 signaling mediated by MAPKAP kinases pid 21
srf PDGF signaling pathway panther 113
srf PDGFR-alpha signaling pathway pid 22
srf PDGFR-beta signaling pathway pid 125
srf Ras Pathway panther 69
srf RHO GTPases Activate Formins reactome 114
srf RhoA signaling pathway pid 46
srf Signaling events mediated by HDAC Class II pid 58
srf Trk receptor signaling mediated by the MAPK pathway pid 34
srf MAPK signaling pathway kegg 264
srf Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
srf Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 wikipathways 15
srf Hs_Mesodermal_Commitment_Pathway_WP2857_87780 wikipathways 47
srf Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 wikipathways 13
Mef2a CDO in myogenesis reactome 29
Mef2a ERK/MAPK targets reactome 17
Mef2a Signaling mediated by p38-alpha and p38-beta pid 35
Mef2a TGF_beta_Receptor netpath 220
Mef2a Hs_p38_MAPK_Signaling_Pathway_WP400_72084 wikipathways 28
Mef2d CDO in myogenesis reactome 29
Mef2d Circadian Clock reactome 49
Mef2d p38 MAPK pathway panther 31
Mef2d Role of Calcineurin-dependent NFAT signaling in lymphocytes pid 54
Mef2d Signaling events mediated by HDAC Class III pid 41
Mef2d Transcriptional activation of mitochondrial biogenesis reactome 43
Mef2c CDO in myogenesis reactome 29
Mef2c Circadian Clock reactome 49
Mef2c ErbB1 downstream signaling pid 105
Mef2c ERK/MAPK targets reactome 17
Mef2c Notch netpath 76
Mef2c Oxidative stress response panther 23
Mef2c p38 MAPK pathway panther 31
Mef2c Regulation of nuclear SMAD2/3 signaling pid 82
Mef2c Regulation of retinoblastoma protein pid 67
Mef2c Signaling events mediated by HDAC Class II pid 58
Mef2c Signaling mediated by p38-alpha and p38-beta pid 35
Mef2c TGF_beta_Receptor netpath 220
Mef2c Transcriptional activation of mitochondrial biogenesis reactome 43
Mef2c Trk receptor signaling mediated by the MAPK pathway pid 34
Mef2c MAPK signaling pathway kegg 264
Mef2c Hs_Endochondral_Ossification_WP474_87977 wikipathways 43
Mef2c Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
Mef2c Hs_Heart_Development_WP1591_90186 wikipathways 28
Mef2c Hs_Oxidation_by_Cytochrome_P450_WP43_84102 wikipathways 14
Mef2c Hs_TGF-beta_Signaling_Pathway_WP366_90028 wikipathways 67
srf Coregulation of Androgen receptor activity pid 61
srf ErbB1 downstream signaling pid 105
srf Interleukin signaling pathway panther 86
srf p38 MAPK pathway panther 31
srf p38 signaling mediated by MAPKAP kinases pid 21
srf PDGF signaling pathway panther 113
srf PDGFR-alpha signaling pathway pid 22
srf PDGFR-beta signaling pathway pid 125
srf Ras Pathway panther 69
srf RHO GTPases Activate Formins reactome 114
srf RhoA signaling pathway pid 46
srf Signaling events mediated by HDAC Class II pid 58
srf Trk receptor signaling mediated by the MAPK pathway pid 34
srf MAPK signaling pathway kegg 264
srf Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
srf Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 wikipathways 15
srf Hs_Mesodermal_Commitment_Pathway_WP2857_87780 wikipathways 47
srf Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 wikipathways 13
Mef2a CDO in myogenesis reactome 29
Mef2a ERK/MAPK targets reactome 17
Mef2a Signaling mediated by p38-alpha and p38-beta pid 35
Mef2a TGF_beta_Receptor netpath 220
Mef2a Hs_p38_MAPK_Signaling_Pathway_WP400_72084 wikipathways 28
Mef2d CDO in myogenesis reactome 29
Mef2d Circadian Clock reactome 49
Mef2d p38 MAPK pathway panther 31
Mef2d Role of Calcineurin-dependent NFAT signaling in lymphocytes pid 54
Mef2d Signaling events mediated by HDAC Class III pid 41
Mef2d Transcriptional activation of mitochondrial biogenesis reactome 43
Mef2c CDO in myogenesis reactome 29
Mef2c Circadian Clock reactome 49
Mef2c ErbB1 downstream signaling pid 105
Mef2c ERK/MAPK targets reactome 17
Mef2c Notch netpath 76
Mef2c Oxidative stress response panther 23
Mef2c p38 MAPK pathway panther 31
Mef2c Regulation of nuclear SMAD2/3 signaling pid 82
Mef2c Regulation of retinoblastoma protein pid 67
Mef2c Signaling events mediated by HDAC Class II pid 58
Mef2c Signaling mediated by p38-alpha and p38-beta pid 35
Mef2c TGF_beta_Receptor netpath 220
Mef2c Transcriptional activation of mitochondrial biogenesis reactome 43
Mef2c Trk receptor signaling mediated by the MAPK pathway pid 34
Mef2c MAPK signaling pathway kegg 264
Mef2c Hs_Endochondral_Ossification_WP474_87977 wikipathways 43
Mef2c Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
Mef2c Hs_Heart_Development_WP1591_90186 wikipathways 28
Mef2c Hs_Oxidation_by_Cytochrome_P450_WP43_84102 wikipathways 14
Mef2c Hs_TGF-beta_Signaling_Pathway_WP366_90028 wikipathways 67
srf Coregulation of Androgen receptor activity pid 61
srf ErbB1 downstream signaling pid 105
srf Interleukin signaling pathway panther 86
srf p38 MAPK pathway panther 31
srf p38 signaling mediated by MAPKAP kinases pid 21
srf PDGF signaling pathway panther 113
srf PDGFR-alpha signaling pathway pid 22
srf PDGFR-beta signaling pathway pid 125
srf Ras Pathway panther 69
srf RHO GTPases Activate Formins reactome 114
srf RhoA signaling pathway pid 46
srf Signaling events mediated by HDAC Class II pid 58
srf Trk receptor signaling mediated by the MAPK pathway pid 34
srf MAPK signaling pathway kegg 264
srf Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
srf Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 wikipathways 15
srf Hs_Mesodermal_Commitment_Pathway_WP2857_87780 wikipathways 47
srf Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 wikipathways 13
Mef2a CDO in myogenesis reactome 29
Mef2a ERK/MAPK targets reactome 17
Mef2a Signaling mediated by p38-alpha and p38-beta pid 35
Mef2a TGF_beta_Receptor netpath 220
Mef2a Hs_p38_MAPK_Signaling_Pathway_WP400_72084 wikipathways 28
Mef2d CDO in myogenesis reactome 29
Mef2d Circadian Clock reactome 49
Mef2d p38 MAPK pathway panther 31
Mef2d Role of Calcineurin-dependent NFAT signaling in lymphocytes pid 54
Mef2d Signaling events mediated by HDAC Class III pid 41
Mef2d Transcriptional activation of mitochondrial biogenesis reactome 43
Mef2c CDO in myogenesis reactome 29
Mef2c Circadian Clock reactome 49
Mef2c ErbB1 downstream signaling pid 105
Mef2c ERK/MAPK targets reactome 17
Mef2c Notch netpath 76
Mef2c Oxidative stress response panther 23
Mef2c p38 MAPK pathway panther 31
Mef2c Regulation of nuclear SMAD2/3 signaling pid 82
Mef2c Regulation of retinoblastoma protein pid 67
Mef2c Signaling events mediated by HDAC Class II pid 58
Mef2c Signaling mediated by p38-alpha and p38-beta pid 35
Mef2c TGF_beta_Receptor netpath 220
Mef2c Transcriptional activation of mitochondrial biogenesis reactome 43
Mef2c Trk receptor signaling mediated by the MAPK pathway pid 34
Mef2c MAPK signaling pathway kegg 264
Mef2c Hs_Endochondral_Ossification_WP474_87977 wikipathways 43
Mef2c Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
Mef2c Hs_Heart_Development_WP1591_90186 wikipathways 28
Mef2c Hs_Oxidation_by_Cytochrome_P450_WP43_84102 wikipathways 14
Mef2c Hs_TGF-beta_Signaling_Pathway_WP366_90028 wikipathways 67
srf Coregulation of Androgen receptor activity pid 61
srf ErbB1 downstream signaling pid 105
srf Interleukin signaling pathway panther 86
srf p38 MAPK pathway panther 31
srf p38 signaling mediated by MAPKAP kinases pid 21
srf PDGF signaling pathway panther 113
srf PDGFR-alpha signaling pathway pid 22
srf PDGFR-beta signaling pathway pid 125
srf Ras Pathway panther 69
srf RHO GTPases Activate Formins reactome 114
srf RhoA signaling pathway pid 46
srf Signaling events mediated by HDAC Class II pid 58
srf Trk receptor signaling mediated by the MAPK pathway pid 34
srf MAPK signaling pathway kegg 264
srf Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
srf Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 wikipathways 15
srf Hs_Mesodermal_Commitment_Pathway_WP2857_87780 wikipathways 47
srf Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 wikipathways 13
Mef2a CDO in myogenesis reactome 29
Mef2a ERK/MAPK targets reactome 17
Mef2a Signaling mediated by p38-alpha and p38-beta pid 35
Mef2a TGF_beta_Receptor netpath 220
Mef2a Hs_p38_MAPK_Signaling_Pathway_WP400_72084 wikipathways 28
Mef2d CDO in myogenesis reactome 29
Mef2d Circadian Clock reactome 49
Mef2d p38 MAPK pathway panther 31
Mef2d Role of Calcineurin-dependent NFAT signaling in lymphocytes pid 54
Mef2d Signaling events mediated by HDAC Class III pid 41
Mef2d Transcriptional activation of mitochondrial biogenesis reactome 43
Mef2c CDO in myogenesis reactome 29
Mef2c Circadian Clock reactome 49
Mef2c ErbB1 downstream signaling pid 105
Mef2c ERK/MAPK targets reactome 17
Mef2c Notch netpath 76
Mef2c Oxidative stress response panther 23
Mef2c p38 MAPK pathway panther 31
Mef2c Regulation of nuclear SMAD2/3 signaling pid 82
Mef2c Regulation of retinoblastoma protein pid 67
Mef2c Signaling events mediated by HDAC Class II pid 58
Mef2c Signaling mediated by p38-alpha and p38-beta pid 35
Mef2c TGF_beta_Receptor netpath 220
Mef2c Transcriptional activation of mitochondrial biogenesis reactome 43
Mef2c Trk receptor signaling mediated by the MAPK pathway pid 34
Mef2c MAPK signaling pathway kegg 264
Mef2c Hs_Endochondral_Ossification_WP474_87977 wikipathways 43
Mef2c Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
Mef2c Hs_Heart_Development_WP1591_90186 wikipathways 28
Mef2c Hs_Oxidation_by_Cytochrome_P450_WP43_84102 wikipathways 14
Mef2c Hs_TGF-beta_Signaling_Pathway_WP366_90028 wikipathways 67
srf Coregulation of Androgen receptor activity pid 61
srf ErbB1 downstream signaling pid 105
srf Interleukin signaling pathway panther 86
srf p38 MAPK pathway panther 31
srf p38 signaling mediated by MAPKAP kinases pid 21
srf PDGF signaling pathway panther 113
srf PDGFR-alpha signaling pathway pid 22
srf PDGFR-beta signaling pathway pid 125
srf Ras Pathway panther 69
srf RHO GTPases Activate Formins reactome 114
srf RhoA signaling pathway pid 46
srf Signaling events mediated by HDAC Class II pid 58
srf Trk receptor signaling mediated by the MAPK pathway pid 34
srf MAPK signaling pathway kegg 264
srf Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
srf Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 wikipathways 15
srf Hs_Mesodermal_Commitment_Pathway_WP2857_87780 wikipathways 47
srf Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 wikipathways 13
Mef2a CDO in myogenesis reactome 29
Mef2a ERK/MAPK targets reactome 17
Mef2a Signaling mediated by p38-alpha and p38-beta pid 35
Mef2a TGF_beta_Receptor netpath 220
Mef2a Hs_p38_MAPK_Signaling_Pathway_WP400_72084 wikipathways 28
Mef2d CDO in myogenesis reactome 29
Mef2d Circadian Clock reactome 49
Mef2d p38 MAPK pathway panther 31
Mef2d Role of Calcineurin-dependent NFAT signaling in lymphocytes pid 54
Mef2d Signaling events mediated by HDAC Class III pid 41
Mef2d Transcriptional activation of mitochondrial biogenesis reactome 43
Mef2c CDO in myogenesis reactome 29
Mef2c Circadian Clock reactome 49
Mef2c ErbB1 downstream signaling pid 105
Mef2c ERK/MAPK targets reactome 17
Mef2c Notch netpath 76
Mef2c Oxidative stress response panther 23
Mef2c p38 MAPK pathway panther 31
Mef2c Regulation of nuclear SMAD2/3 signaling pid 82
Mef2c Regulation of retinoblastoma protein pid 67
Mef2c Signaling events mediated by HDAC Class II pid 58
Mef2c Signaling mediated by p38-alpha and p38-beta pid 35
Mef2c TGF_beta_Receptor netpath 220
Mef2c Transcriptional activation of mitochondrial biogenesis reactome 43
Mef2c Trk receptor signaling mediated by the MAPK pathway pid 34
Mef2c MAPK signaling pathway kegg 264
Mef2c Hs_Endochondral_Ossification_WP474_87977 wikipathways 43
Mef2c Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
Mef2c Hs_Heart_Development_WP1591_90186 wikipathways 28
Mef2c Hs_Oxidation_by_Cytochrome_P450_WP43_84102 wikipathways 14
Mef2c Hs_TGF-beta_Signaling_Pathway_WP366_90028 wikipathways 67
srf Coregulation of Androgen receptor activity pid 61
srf ErbB1 downstream signaling pid 105
srf Interleukin signaling pathway panther 86
srf p38 MAPK pathway panther 31
srf p38 signaling mediated by MAPKAP kinases pid 21
srf PDGF signaling pathway panther 113
srf PDGFR-alpha signaling pathway pid 22
srf PDGFR-beta signaling pathway pid 125
srf Ras Pathway panther 69
srf RHO GTPases Activate Formins reactome 114
srf RhoA signaling pathway pid 46
srf Signaling events mediated by HDAC Class II pid 58
srf Trk receptor signaling mediated by the MAPK pathway pid 34
srf MAPK signaling pathway kegg 264
srf Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
srf Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 wikipathways 15
srf Hs_Mesodermal_Commitment_Pathway_WP2857_87780 wikipathways 47
srf Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 wikipathways 13
Mef2a CDO in myogenesis reactome 29
Mef2a ERK/MAPK targets reactome 17
Mef2a Signaling mediated by p38-alpha and p38-beta pid 35
Mef2a TGF_beta_Receptor netpath 220
Mef2a Hs_p38_MAPK_Signaling_Pathway_WP400_72084 wikipathways 28
Mef2d CDO in myogenesis reactome 29
Mef2d Circadian Clock reactome 49
Mef2d p38 MAPK pathway panther 31
Mef2d Role of Calcineurin-dependent NFAT signaling in lymphocytes pid 54
Mef2d Signaling events mediated by HDAC Class III pid 41
Mef2d Transcriptional activation of mitochondrial biogenesis reactome 43
Mef2c CDO in myogenesis reactome 29
Mef2c Circadian Clock reactome 49
Mef2c ErbB1 downstream signaling pid 105
Mef2c ERK/MAPK targets reactome 17
Mef2c Notch netpath 76
Mef2c Oxidative stress response panther 23
Mef2c p38 MAPK pathway panther 31
Mef2c Regulation of nuclear SMAD2/3 signaling pid 82
Mef2c Regulation of retinoblastoma protein pid 67
Mef2c Signaling events mediated by HDAC Class II pid 58
Mef2c Signaling mediated by p38-alpha and p38-beta pid 35
Mef2c TGF_beta_Receptor netpath 220
Mef2c Transcriptional activation of mitochondrial biogenesis reactome 43
Mef2c Trk receptor signaling mediated by the MAPK pathway pid 34
Mef2c MAPK signaling pathway kegg 264
Mef2c Hs_Endochondral_Ossification_WP474_87977 wikipathways 43
Mef2c Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
Mef2c Hs_Heart_Development_WP1591_90186 wikipathways 28
Mef2c Hs_Oxidation_by_Cytochrome_P450_WP43_84102 wikipathways 14
Mef2c Hs_TGF-beta_Signaling_Pathway_WP366_90028 wikipathways 67
srf Coregulation of Androgen receptor activity pid 61
srf ErbB1 downstream signaling pid 105
srf Interleukin signaling pathway panther 86
srf p38 MAPK pathway panther 31
srf p38 signaling mediated by MAPKAP kinases pid 21
srf PDGF signaling pathway panther 113
srf PDGFR-alpha signaling pathway pid 22
srf PDGFR-beta signaling pathway pid 125
srf Ras Pathway panther 69
srf RHO GTPases Activate Formins reactome 114
srf RhoA signaling pathway pid 46
srf Signaling events mediated by HDAC Class II pid 58
srf Trk receptor signaling mediated by the MAPK pathway pid 34
srf MAPK signaling pathway kegg 264
srf Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
srf Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 wikipathways 15
srf Hs_Mesodermal_Commitment_Pathway_WP2857_87780 wikipathways 47
srf Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 wikipathways 13
Mef2a CDO in myogenesis reactome 29
Mef2a ERK/MAPK targets reactome 17
Mef2a Signaling mediated by p38-alpha and p38-beta pid 35
Mef2a TGF_beta_Receptor netpath 220
Mef2a Hs_p38_MAPK_Signaling_Pathway_WP400_72084 wikipathways 28
Mef2d CDO in myogenesis reactome 29
Mef2d Circadian Clock reactome 49
Mef2d p38 MAPK pathway panther 31
Mef2d Role of Calcineurin-dependent NFAT signaling in lymphocytes pid 54
Mef2d Signaling events mediated by HDAC Class III pid 41
Mef2d Transcriptional activation of mitochondrial biogenesis reactome 43
Mef2c CDO in myogenesis reactome 29
Mef2c Circadian Clock reactome 49
Mef2c ErbB1 downstream signaling pid 105
Mef2c ERK/MAPK targets reactome 17
Mef2c Notch netpath 76
Mef2c Oxidative stress response panther 23
Mef2c p38 MAPK pathway panther 31
Mef2c Regulation of nuclear SMAD2/3 signaling pid 82
Mef2c Regulation of retinoblastoma protein pid 67
Mef2c Signaling events mediated by HDAC Class II pid 58
Mef2c Signaling mediated by p38-alpha and p38-beta pid 35
Mef2c TGF_beta_Receptor netpath 220
Mef2c Transcriptional activation of mitochondrial biogenesis reactome 43
Mef2c Trk receptor signaling mediated by the MAPK pathway pid 34
Mef2c MAPK signaling pathway kegg 264
Mef2c Hs_Endochondral_Ossification_WP474_87977 wikipathways 43
Mef2c Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
Mef2c Hs_Heart_Development_WP1591_90186 wikipathways 28
Mef2c Hs_Oxidation_by_Cytochrome_P450_WP43_84102 wikipathways 14
Mef2c Hs_TGF-beta_Signaling_Pathway_WP366_90028 wikipathways 67
srf Coregulation of Androgen receptor activity pid 61
srf ErbB1 downstream signaling pid 105
srf Interleukin signaling pathway panther 86
srf p38 MAPK pathway panther 31
srf p38 signaling mediated by MAPKAP kinases pid 21
srf PDGF signaling pathway panther 113
srf PDGFR-alpha signaling pathway pid 22
srf PDGFR-beta signaling pathway pid 125
srf Ras Pathway panther 69
srf RHO GTPases Activate Formins reactome 114
srf RhoA signaling pathway pid 46
srf Signaling events mediated by HDAC Class II pid 58
srf Trk receptor signaling mediated by the MAPK pathway pid 34
srf MAPK signaling pathway kegg 264
srf Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
srf Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 wikipathways 15
srf Hs_Mesodermal_Commitment_Pathway_WP2857_87780 wikipathways 47
srf Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 wikipathways 13
Mef2a CDO in myogenesis reactome 29
Mef2a ERK/MAPK targets reactome 17
Mef2a Signaling mediated by p38-alpha and p38-beta pid 35
Mef2a TGF_beta_Receptor netpath 220
Mef2a Hs_p38_MAPK_Signaling_Pathway_WP400_72084 wikipathways 28
Mef2d CDO in myogenesis reactome 29
Mef2d Circadian Clock reactome 49
Mef2d p38 MAPK pathway panther 31
Mef2d Role of Calcineurin-dependent NFAT signaling in lymphocytes pid 54
Mef2d Signaling events mediated by HDAC Class III pid 41
Mef2d Transcriptional activation of mitochondrial biogenesis reactome 43
Mef2c CDO in myogenesis reactome 29
Mef2c Circadian Clock reactome 49
Mef2c ErbB1 downstream signaling pid 105
Mef2c ERK/MAPK targets reactome 17
Mef2c Notch netpath 76
Mef2c Oxidative stress response panther 23
Mef2c p38 MAPK pathway panther 31
Mef2c Regulation of nuclear SMAD2/3 signaling pid 82
Mef2c Regulation of retinoblastoma protein pid 67
Mef2c Signaling events mediated by HDAC Class II pid 58
Mef2c Signaling mediated by p38-alpha and p38-beta pid 35
Mef2c TGF_beta_Receptor netpath 220
Mef2c Transcriptional activation of mitochondrial biogenesis reactome 43
Mef2c Trk receptor signaling mediated by the MAPK pathway pid 34
Mef2c MAPK signaling pathway kegg 264
Mef2c Hs_Endochondral_Ossification_WP474_87977 wikipathways 43
Mef2c Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
Mef2c Hs_Heart_Development_WP1591_90186 wikipathways 28
Mef2c Hs_Oxidation_by_Cytochrome_P450_WP43_84102 wikipathways 14
Mef2c Hs_TGF-beta_Signaling_Pathway_WP366_90028 wikipathways 67
srf Coregulation of Androgen receptor activity pid 61
srf ErbB1 downstream signaling pid 105
srf Interleukin signaling pathway panther 86
srf p38 MAPK pathway panther 31
srf p38 signaling mediated by MAPKAP kinases pid 21
srf PDGF signaling pathway panther 113
srf PDGFR-alpha signaling pathway pid 22
srf PDGFR-beta signaling pathway pid 125
srf Ras Pathway panther 69
srf RHO GTPases Activate Formins reactome 114
srf RhoA signaling pathway pid 46
srf Signaling events mediated by HDAC Class II pid 58
srf Trk receptor signaling mediated by the MAPK pathway pid 34
srf MAPK signaling pathway kegg 264
srf Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
srf Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 wikipathways 15
srf Hs_Mesodermal_Commitment_Pathway_WP2857_87780 wikipathways 47
srf Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 wikipathways 13
Mef2a CDO in myogenesis reactome 29
Mef2a ERK/MAPK targets reactome 17
Mef2a Signaling mediated by p38-alpha and p38-beta pid 35
Mef2a TGF_beta_Receptor netpath 220
Mef2a Hs_p38_MAPK_Signaling_Pathway_WP400_72084 wikipathways 28
Mef2d CDO in myogenesis reactome 29
Mef2d Circadian Clock reactome 49
Mef2d p38 MAPK pathway panther 31
Mef2d Role of Calcineurin-dependent NFAT signaling in lymphocytes pid 54
Mef2d Signaling events mediated by HDAC Class III pid 41
Mef2d Transcriptional activation of mitochondrial biogenesis reactome 43
Mef2c CDO in myogenesis reactome 29
Mef2c Circadian Clock reactome 49
Mef2c ErbB1 downstream signaling pid 105
Mef2c ERK/MAPK targets reactome 17
Mef2c Notch netpath 76
Mef2c Oxidative stress response panther 23
Mef2c p38 MAPK pathway panther 31
Mef2c Regulation of nuclear SMAD2/3 signaling pid 82
Mef2c Regulation of retinoblastoma protein pid 67
Mef2c Signaling events mediated by HDAC Class II pid 58
Mef2c Signaling mediated by p38-alpha and p38-beta pid 35
Mef2c TGF_beta_Receptor netpath 220
Mef2c Transcriptional activation of mitochondrial biogenesis reactome 43
Mef2c Trk receptor signaling mediated by the MAPK pathway pid 34
Mef2c MAPK signaling pathway kegg 264
Mef2c Hs_Endochondral_Ossification_WP474_87977 wikipathways 43
Mef2c Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
Mef2c Hs_Heart_Development_WP1591_90186 wikipathways 28
Mef2c Hs_Oxidation_by_Cytochrome_P450_WP43_84102 wikipathways 14
Mef2c Hs_TGF-beta_Signaling_Pathway_WP366_90028 wikipathways 67

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs