About Enhancer

Enhancer ID: E_02_0848
Species: human
Position : chr4:55565908-55608014
Biosample name:
Experiment class : Low+High throughput
Enhancer type: Super-Enhancer
Disease: --
Pubmed ID:  26550034
Enhancer experiment: ChIP-seq,ChIP
Enhancer experiment description: The genome-wide mapping of Tip60 binding in mESCs by chromatin immunoprecipitation (ChIP) coupled with high-throughput sequencing (ChIP-seq) shows that the Tip60 complex is present at promoter regions of predominantly active genes that are bound by RNA polymerase II (Pol II) and contain the H3K4me3 histone mark. The coactivator HAT complexes, Tip60- and Mof (KAT8)- containing (NSL and MSL), show a global overlap at promoters, whereas distinct binding profiles at enhancers suggest different regulatory functions of each essential HAT complex. Interestingly, Tip60 enrichment peaks at about 200 bp downstream of the transcription start sites suggesting a function for the Tip60 complexes in addition to histone acetylation.

About Target gene

Target gene : Klf4(EZF,Gklf,Zie),Klf4(EZF,Gklf,Zie),Klf4(EZF,Gklf,Zie),Klf4(EZF,Gklf,Zie),Klf4(EZF,Gklf,Zie),Klf4(EZF,Gklf,Zie),Klf4(EZF,Gklf,Zie)
Strong evidence: --
Less strong evidence: ChIP-seq
Target gene experiment description: As two of the so-called super Enhancer regions of the Nanog gene and the Enhancer of the Klf4 gene are bound by Tip60,but not by Nsl1 and Msl1(Fig.?7a, b).;As two of the so-called super Enhancer regions of the Nanog gene and the Enhancer of the Klf4 gene are bound by Tip60,but not by Nsl1 and Msl1(Fig.?7a, b).;As two of the so-called super Enhancer regions of the Nanog gene and the Enhancer of the Klf4 gene are bound by Tip60,but not by Nsl1 and Msl1(Fig.?7a, b).;As two of the so-called super Enhancer regions of the Nanog gene and the Enhancer of the Klf4 gene are bound by Tip60,but not by Nsl1 and Msl1(Fig.?7a, b).;As two of the so-called super Enhancer regions of the Nanog gene and the Enhancer of the Klf4 gene are bound by Tip60,but not by Nsl1 and Msl1(Fig.?7a, b).;As two of the so-called super Enhancer regions of the Nanog gene and the Enhancer of the Klf4 gene are bound by Tip60,but not by Nsl1 and Msl1(Fig.?7a, b).;As two of the so-called super Enhancer regions of the Nanog gene and the Enhancer of the Klf4 gene are bound by Tip60,but not by Nsl1 and Msl1(Fig.?7a, b).

About TF

TF name : Kat5(ESA1,HTATIP,HTATIP1,PLIP,TIP,TIP60,ZC2HC5,cPLA2)Kat5(ESA1,HTATIP,HTATIP1,PLIP,TIP,TIP60,ZC2HC5,cPLA2)Kat5(ESA1,HTATIP,HTATIP1,PLIP,TIP,TIP60,ZC2HC5,cPLA2)Kat5(ESA1,HTATIP,HTATIP1,PLIP,TIP,TIP60,ZC2HC5,cPLA2)Kat5(ESA1,HTATIP,HTATIP1,PLIP,TIP,TIP60,ZC2HC5,cPLA2)Kat5(ESA1,HTATIP,HTATIP1,PLIP,TIP,TIP60,ZC2HC5,cPLA2)Kat5(ESA1,HTATIP,HTATIP1,PLIP,TIP,TIP60,ZC2HC5,cPLA2)
TF experiment: ChIP-qPCR,ChIP-seq
TF experiment description: The validation of several randomly selected ChIP-seq positive sites by ChIP-qPCR indicated specific Tip60 enrichments at these sites, when compared to control IgG ChIP signals and to background enrichment at an intergenic region negative for Tip60 binding (Fig.?1b).These results, together with the ChIP-qPCR validation (Fig.? 1b), indicate that the obtained anti-Tip60 ChIP-seq signal is specific.;The validation of several randomly selected ChIP-seq positive sites by ChIP-qPCR indicated specific Tip60 enrichments at these sites, when compared to control IgG ChIP signals and to background enrichment at an intergenic region negative for Tip60 binding (Fig.?1b).These results, together with the ChIP-qPCR validation (Fig.? 1b), indicate that the obtained anti-Tip60 ChIP-seq signal is specific.;The validation of several randomly selected ChIP-seq positive sites by ChIP-qPCR indicated specific Tip60 enrichments at these sites, when compared to control IgG ChIP signals and to background enrichment at an intergenic region negative for Tip60 binding (Fig.?1b).These results, together with the ChIP-qPCR validation (Fig.? 1b), indicate that the obtained anti-Tip60 ChIP-seq signal is specific.;The validation of several randomly selected ChIP-seq positive sites by ChIP-qPCR indicated specific Tip60 enrichments at these sites, when compared to control IgG ChIP signals and to background enrichment at an intergenic region negative for Tip60 binding (Fig.?1b).These results, together with the ChIP-qPCR validation (Fig.? 1b), indicate that the obtained anti-Tip60 ChIP-seq signal is specific.;The validation of several randomly selected ChIP-seq positive sites by ChIP-qPCR indicated specific Tip60 enrichments at these sites, when compared to control IgG ChIP signals and to background enrichment at an intergenic region negative for Tip60 binding (Fig.?1b).These results, together with the ChIP-qPCR validation (Fig.? 1b), indicate that the obtained anti-Tip60 ChIP-seq signal is specific.;The validation of several randomly selected ChIP-seq positive sites by ChIP-qPCR indicated specific Tip60 enrichments at these sites, when compared to control IgG ChIP signals and to background enrichment at an intergenic region negative for Tip60 binding (Fig.?1b).These results, together with the ChIP-qPCR validation (Fig.? 1b), indicate that the obtained anti-Tip60 ChIP-seq signal is specific.;The validation of several randomly selected ChIP-seq positive sites by ChIP-qPCR indicated specific Tip60 enrichments at these sites, when compared to control IgG ChIP signals and to background enrichment at an intergenic region negative for Tip60 binding (Fig.?1b).These results, together with the ChIP-qPCR validation (Fig.? 1b), indicate that the obtained anti-Tip60 ChIP-seq signal is specific.

About Function

Enhancer function : --
Enhancer function experiment: --
Enhancer function
experiment description:		 --

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
Kat5 Alzheimer disease-amyloid secretase pathway panther 56
Kat5 Alzheimer disease-presenilin pathway panther 98
Kat5 AndrogenReceptor netpath 167
Kat5 ATF-2 transcription factor network pid 59
Kat5 ATM pathway pid 34
Kat5 C-MYC pathway pid 25
Kat5 DNA Damage/Telomere Stress Induced Senescence reactome 64
Kat5 Formation of the beta-catenin:TCF transactivating complex reactome 88
Kat5 G2/M DNA damage checkpoint reactome 84
Kat5 HATs acetylate histones reactome 142
Kat5 HDR through Homologous Recombination (HRR) reactome 46
Kat5 HDR through Single Strand Annealing (SSA) reactome 37
Kat5 Homologous DNA Pairing and Strand Exchange reactome 25
Kat5 IL9 netpath 24
Kat5 Nonhomologous End-Joining (NHEJ) reactome 69
Kat5 p53 pathway pid 59
Kat5 p73 transcription factor network pid 80
Kat5 Presynaptic phase of homologous DNA pairing and strand exchange reactome 39
Kat5 Processing of DNA double-strand break ends reactome 98
Kat5 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks reactome 75
Kat5 Regulation of Androgen receptor activity pid 54
Kat5 Regulation of TP53 Activity through Phosphorylation reactome 89
Kat5 Resolution of D-loop Structures through Holliday Junction Intermediates reactome 33
Kat5 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) reactome 26
Kat5 Sensing of DNA Double Strand Breaks reactome 6
Kat5 Validated targets of C-MYC transcriptional activation pid 80
Kat5 Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 wikipathways 50
Kat5 Alzheimer disease-amyloid secretase pathway panther 56
Kat5 Alzheimer disease-presenilin pathway panther 98
Kat5 AndrogenReceptor netpath 167
Kat5 ATF-2 transcription factor network pid 59
Kat5 ATM pathway pid 34
Kat5 C-MYC pathway pid 25
Kat5 DNA Damage/Telomere Stress Induced Senescence reactome 64
Kat5 Formation of the beta-catenin:TCF transactivating complex reactome 88
Kat5 G2/M DNA damage checkpoint reactome 84
Kat5 HATs acetylate histones reactome 142
Kat5 HDR through Homologous Recombination (HRR) reactome 46
Kat5 HDR through Single Strand Annealing (SSA) reactome 37
Kat5 Homologous DNA Pairing and Strand Exchange reactome 25
Kat5 IL9 netpath 24
Kat5 Nonhomologous End-Joining (NHEJ) reactome 69
Kat5 p53 pathway pid 59
Kat5 p73 transcription factor network pid 80
Kat5 Presynaptic phase of homologous DNA pairing and strand exchange reactome 39
Kat5 Processing of DNA double-strand break ends reactome 98
Kat5 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks reactome 75
Kat5 Regulation of Androgen receptor activity pid 54
Kat5 Regulation of TP53 Activity through Phosphorylation reactome 89
Kat5 Resolution of D-loop Structures through Holliday Junction Intermediates reactome 33
Kat5 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) reactome 26
Kat5 Sensing of DNA Double Strand Breaks reactome 6
Kat5 Validated targets of C-MYC transcriptional activation pid 80
Kat5 Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 wikipathways 50
Kat5 Alzheimer disease-amyloid secretase pathway panther 56
Kat5 Alzheimer disease-presenilin pathway panther 98
Kat5 AndrogenReceptor netpath 167
Kat5 ATF-2 transcription factor network pid 59
Kat5 ATM pathway pid 34
Kat5 C-MYC pathway pid 25
Kat5 DNA Damage/Telomere Stress Induced Senescence reactome 64
Kat5 Formation of the beta-catenin:TCF transactivating complex reactome 88
Kat5 G2/M DNA damage checkpoint reactome 84
Kat5 HATs acetylate histones reactome 142
Kat5 HDR through Homologous Recombination (HRR) reactome 46
Kat5 HDR through Single Strand Annealing (SSA) reactome 37
Kat5 Homologous DNA Pairing and Strand Exchange reactome 25
Kat5 IL9 netpath 24
Kat5 Nonhomologous End-Joining (NHEJ) reactome 69
Kat5 p53 pathway pid 59
Kat5 p73 transcription factor network pid 80
Kat5 Presynaptic phase of homologous DNA pairing and strand exchange reactome 39
Kat5 Processing of DNA double-strand break ends reactome 98
Kat5 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks reactome 75
Kat5 Regulation of Androgen receptor activity pid 54
Kat5 Regulation of TP53 Activity through Phosphorylation reactome 89
Kat5 Resolution of D-loop Structures through Holliday Junction Intermediates reactome 33
Kat5 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) reactome 26
Kat5 Sensing of DNA Double Strand Breaks reactome 6
Kat5 Validated targets of C-MYC transcriptional activation pid 80
Kat5 Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 wikipathways 50
Kat5 Alzheimer disease-amyloid secretase pathway panther 56
Kat5 Alzheimer disease-presenilin pathway panther 98
Kat5 AndrogenReceptor netpath 167
Kat5 ATF-2 transcription factor network pid 59
Kat5 ATM pathway pid 34
Kat5 C-MYC pathway pid 25
Kat5 DNA Damage/Telomere Stress Induced Senescence reactome 64
Kat5 Formation of the beta-catenin:TCF transactivating complex reactome 88
Kat5 G2/M DNA damage checkpoint reactome 84
Kat5 HATs acetylate histones reactome 142
Kat5 HDR through Homologous Recombination (HRR) reactome 46
Kat5 HDR through Single Strand Annealing (SSA) reactome 37
Kat5 Homologous DNA Pairing and Strand Exchange reactome 25
Kat5 IL9 netpath 24
Kat5 Nonhomologous End-Joining (NHEJ) reactome 69
Kat5 p53 pathway pid 59
Kat5 p73 transcription factor network pid 80
Kat5 Presynaptic phase of homologous DNA pairing and strand exchange reactome 39
Kat5 Processing of DNA double-strand break ends reactome 98
Kat5 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks reactome 75
Kat5 Regulation of Androgen receptor activity pid 54
Kat5 Regulation of TP53 Activity through Phosphorylation reactome 89
Kat5 Resolution of D-loop Structures through Holliday Junction Intermediates reactome 33
Kat5 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) reactome 26
Kat5 Sensing of DNA Double Strand Breaks reactome 6
Kat5 Validated targets of C-MYC transcriptional activation pid 80
Kat5 Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 wikipathways 50
Kat5 Alzheimer disease-amyloid secretase pathway panther 56
Kat5 Alzheimer disease-presenilin pathway panther 98
Kat5 AndrogenReceptor netpath 167
Kat5 ATF-2 transcription factor network pid 59
Kat5 ATM pathway pid 34
Kat5 C-MYC pathway pid 25
Kat5 DNA Damage/Telomere Stress Induced Senescence reactome 64
Kat5 Formation of the beta-catenin:TCF transactivating complex reactome 88
Kat5 G2/M DNA damage checkpoint reactome 84
Kat5 HATs acetylate histones reactome 142
Kat5 HDR through Homologous Recombination (HRR) reactome 46
Kat5 HDR through Single Strand Annealing (SSA) reactome 37
Kat5 Homologous DNA Pairing and Strand Exchange reactome 25
Kat5 IL9 netpath 24
Kat5 Nonhomologous End-Joining (NHEJ) reactome 69
Kat5 p53 pathway pid 59
Kat5 p73 transcription factor network pid 80
Kat5 Presynaptic phase of homologous DNA pairing and strand exchange reactome 39
Kat5 Processing of DNA double-strand break ends reactome 98
Kat5 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks reactome 75
Kat5 Regulation of Androgen receptor activity pid 54
Kat5 Regulation of TP53 Activity through Phosphorylation reactome 89
Kat5 Resolution of D-loop Structures through Holliday Junction Intermediates reactome 33
Kat5 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) reactome 26
Kat5 Sensing of DNA Double Strand Breaks reactome 6
Kat5 Validated targets of C-MYC transcriptional activation pid 80
Kat5 Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 wikipathways 50
Kat5 Alzheimer disease-amyloid secretase pathway panther 56
Kat5 Alzheimer disease-presenilin pathway panther 98
Kat5 AndrogenReceptor netpath 167
Kat5 ATF-2 transcription factor network pid 59
Kat5 ATM pathway pid 34
Kat5 C-MYC pathway pid 25
Kat5 DNA Damage/Telomere Stress Induced Senescence reactome 64
Kat5 Formation of the beta-catenin:TCF transactivating complex reactome 88
Kat5 G2/M DNA damage checkpoint reactome 84
Kat5 HATs acetylate histones reactome 142
Kat5 HDR through Homologous Recombination (HRR) reactome 46
Kat5 HDR through Single Strand Annealing (SSA) reactome 37
Kat5 Homologous DNA Pairing and Strand Exchange reactome 25
Kat5 IL9 netpath 24
Kat5 Nonhomologous End-Joining (NHEJ) reactome 69
Kat5 p53 pathway pid 59
Kat5 p73 transcription factor network pid 80
Kat5 Presynaptic phase of homologous DNA pairing and strand exchange reactome 39
Kat5 Processing of DNA double-strand break ends reactome 98
Kat5 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks reactome 75
Kat5 Regulation of Androgen receptor activity pid 54
Kat5 Regulation of TP53 Activity through Phosphorylation reactome 89
Kat5 Resolution of D-loop Structures through Holliday Junction Intermediates reactome 33
Kat5 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) reactome 26
Kat5 Sensing of DNA Double Strand Breaks reactome 6
Kat5 Validated targets of C-MYC transcriptional activation pid 80
Kat5 Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 wikipathways 50
Kat5 Alzheimer disease-amyloid secretase pathway panther 56
Kat5 Alzheimer disease-presenilin pathway panther 98
Kat5 AndrogenReceptor netpath 167
Kat5 ATF-2 transcription factor network pid 59
Kat5 ATM pathway pid 34
Kat5 C-MYC pathway pid 25
Kat5 DNA Damage/Telomere Stress Induced Senescence reactome 64
Kat5 Formation of the beta-catenin:TCF transactivating complex reactome 88
Kat5 G2/M DNA damage checkpoint reactome 84
Kat5 HATs acetylate histones reactome 142
Kat5 HDR through Homologous Recombination (HRR) reactome 46
Kat5 HDR through Single Strand Annealing (SSA) reactome 37
Kat5 Homologous DNA Pairing and Strand Exchange reactome 25
Kat5 IL9 netpath 24
Kat5 Nonhomologous End-Joining (NHEJ) reactome 69
Kat5 p53 pathway pid 59
Kat5 p73 transcription factor network pid 80
Kat5 Presynaptic phase of homologous DNA pairing and strand exchange reactome 39
Kat5 Processing of DNA double-strand break ends reactome 98
Kat5 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks reactome 75
Kat5 Regulation of Androgen receptor activity pid 54
Kat5 Regulation of TP53 Activity through Phosphorylation reactome 89
Kat5 Resolution of D-loop Structures through Holliday Junction Intermediates reactome 33
Kat5 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) reactome 26
Kat5 Sensing of DNA Double Strand Breaks reactome 6
Kat5 Validated targets of C-MYC transcriptional activation pid 80
Kat5 Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 wikipathways 50

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs