About Enhancer
| Enhancer ID: | E_02_0860 |
| Species: | human |
| Position : | chr1:214150511-214151337   |
| Biosample name: | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer |
| Disease: | Lymphedema |
| Pubmed ID: | 26214525 |
| Enhancer experiment: | ChIP-seq,Luciferase Reporter Assay |
| Enhancer experiment description: | The 11 kb element was also cloned distally into the enhancer site of pGL4.12, together with a subcloned region of the Prox1 +4.5 kb element (containing GATA sites 4 and 5, see Methods for details) acting as a promoter. This addition resulted in a significant increase in luciferase activity, demonstrating that the Prox1 11 kb element is capable of acting as an enhancer (Figure 1D). |
About Target gene
| Target gene : | PROX1(PROX1),PROX1(PROX1),PROX1(PROX1) |
| Strong evidence: | -- |
| Less strong evidence: | Luciferase Reporter Assay |
| Target gene experiment description: | The 11 kb element was also cloned distally into the enhancer site of pGL4.12, together with a subcloned region of the Prox1 +4.5 kb element (containing GATA sites 4 and 5, see Methods for details) acting as a promoter. This addition resulted in a significant increase in luciferase activity, demonstrating that the Prox1 11 kb element is capable of acting as an enhancer (Figure 1D). ;The 11 kb element was also cloned distally into the enhancer site of pGL4.12, together with a subcloned region of the Prox1 +4.5 kb element (containing GATA sites 4 and 5, see Methods for details) acting as a promoter. This addition resulted in a significant increase in luciferase activity, demonstrating that the Prox1 11 kb element is capable of acting as an enhancer (Figure 1D). ;The 11 kb element was also cloned distally into the enhancer site of pGL4.12, together with a subcloned region of the Prox1 +4.5 kb element (containing GATA sites 4 and 5, see Methods for details) acting as a promoter. This addition resulted in a significant increase in luciferase activity, demonstrating that the Prox1 11 kb element is capable of acting as an enhancer (Figure 1D). |
About TF
| TF name : | GATA2(DCML,IMD21,MONOMAC,NFE1B)FOXC2(FKHL14,LD,MFH-1,MFH1)NFATC1(NF-ATC,NF-ATc1.2,NFAT2,NFATc)GATA2(DCML,IMD21,MONOMAC,NFE1B)FOXC2(FKHL14,LD,MFH-1,MFH1)NFATC1(NF-ATC,NF-ATc1.2,NFAT2,NFATc)GATA2(DCML,IMD21,MONOMAC,NFE1B)FOXC2(FKHL14,LD,MFH-1,MFH1)NFATC1(NF-ATC,NF-ATc1.2,NFAT2,NFATc) |
| TF experiment: | ChIP |
| TF experiment description: | ChIP demonstrates that GATA2, FOXC2, and NFATC1 ChIP at the PROX1 11 kb enhancer in LECs and BECs, but not K-562 cells.;ChIP demonstrates that GATA2, FOXC2, and NFATC1 ChIP at the PROX1 11 kb enhancer in LECs and BECs, but not K-562 cells.;ChIP demonstrates that GATA2, FOXC2, and NFATC1 ChIP at the PROX1 11 kb enhancer in LECs and BECs, but not K-562 cells. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene