About Enhancer

Enhancer ID: E_02_0866
Species: mouse
Position : chr3:127641624-127642545
Biosample name:
Experiment class : Low+High throughput
Enhancer type: Enhancer
Disease: --
Pubmed ID:  25804738
Enhancer experiment: ChIP-qPCR,ChIP-seq,RNA-seq
Enhancer experiment description: A conserved 447?bp genomic fragment within this?Neurog2?3? Foxa1-bound peak showed enhancer activity specifically in midbrain floor plate and also in the cerebral cortex, when analysed in mouse transient transgenic experiments at E12.5

About Target gene

Target gene : Neurog2(Atoh4,Math4A,bHLHa8,ngn-2,ngn2),Neurog2(Atoh4,Math4A,bHLHa8,ngn-2,ngn2),Neurog2(Atoh4,Math4A,bHLHa8,ngn-2,ngn2),Neurog2(Atoh4,Math4A,bHLHa8,ngn-2,ngn2),Neurog2(Atoh4,Math4A,bHLHa8,ngn-2,ngn2),Neurog2(Atoh4,Math4A,bHLHa8,ngn-2,ngn2),Neurog2(Atoh4,Math4A,bHLHa8,ngn-2,ngn2),Neurog2(Atoh4,Math4A,bHLHa8,ngn-2,ngn2),Neurog2(Atoh4,Math4A,bHLHa8,ngn-2,ngn2)
Strong evidence: --
Less strong evidence: Transgenic mice,qRT-PCR
Target gene experiment description: By contrast, the identification of a Foxa1-bound peak downstream of Neurog2 coding sequences (Neurog2 3?) raised the possibility that Foxa2 might directly activate Neurog2 expression through this putative Enhancer region in embryonic mDA progenitors.;By contrast, the identification of a Foxa1-bound peak downstream of Neurog2 coding sequences (Neurog2 3?) raised the possibility that Foxa2 might directly activate Neurog2 expression through this putative Enhancer region in embryonic mDA progenitors.;By contrast, the identification of a Foxa1-bound peak downstream of Neurog2 coding sequences (Neurog2 3?) raised the possibility that Foxa2 might directly activate Neurog2 expression through this putative Enhancer region in embryonic mDA progenitors.;By contrast, the identification of a Foxa1-bound peak downstream of Neurog2 coding sequences (Neurog2 3?) raised the possibility that Foxa2 might directly activate Neurog2 expression through this putative Enhancer region in embryonic mDA progenitors.;By contrast, the identification of a Foxa1-bound peak downstream of Neurog2 coding sequences (Neurog2 3?) raised the possibility that Foxa2 might directly activate Neurog2 expression through this putative Enhancer region in embryonic mDA progenitors.;By contrast, the identification of a Foxa1-bound peak downstream of Neurog2 coding sequences (Neurog2 3?) raised the possibility that Foxa2 might directly activate Neurog2 expression through this putative Enhancer region in embryonic mDA progenitors.;By contrast, the identification of a Foxa1-bound peak downstream of Neurog2 coding sequences (Neurog2 3?) raised the possibility that Foxa2 might directly activate Neurog2 expression through this putative Enhancer region in embryonic mDA progenitors.;By contrast, the identification of a Foxa1-bound peak downstream of Neurog2 coding sequences (Neurog2 3?) raised the possibility that Foxa2 might directly activate Neurog2 expression through this putative Enhancer region in embryonic mDA progenitors.;By contrast, the identification of a Foxa1-bound peak downstream of Neurog2 coding sequences (Neurog2 3?) raised the possibility that Foxa2 might directly activate Neurog2 expression through this putative Enhancer region in embryonic mDA progenitors.

About TF

TF name : Otx2(E130306E05Rik)Foxa1(HNF3A,TCF3A)Foxa2(HNF3B,TCF3B)Otx2(E130306E05Rik)Foxa1(HNF3A,TCF3A)Foxa2(HNF3B,TCF3B)Otx2(E130306E05Rik)Foxa1(HNF3A,TCF3A)Foxa2(HNF3B,TCF3B)Otx2(E130306E05Rik)Foxa1(HNF3A,TCF3A)Foxa2(HNF3B,TCF3B)Otx2(E130306E05Rik)Foxa1(HNF3A,TCF3A)Foxa2(HNF3B,TCF3B)Otx2(E130306E05Rik)Foxa1(HNF3A,TCF3A)Foxa2(HNF3B,TCF3B)Otx2(E130306E05Rik)Foxa1(HNF3A,TCF3A)Foxa2(HNF3B,TCF3B)Otx2(E130306E05Rik)Foxa1(HNF3A,TCF3A)Foxa2(HNF3B,TCF3B)Otx2(E130306E05Rik)Foxa1(HNF3A,TCF3A)Foxa2(HNF3B,TCF3B)
TF experiment: ChIP-seq,RNA-seq
TF experiment description: Our genome-wide Foxa1-bound cis-regulatory sequences from ChIP-Seq and Foxa1/2 candidate target genes from RNA-Seq analyses of embryonic midbrain dopamine cells also provide an excellent resource for probing mechanistic insights into gene regulatory networks involved in the differentiation of midbrain dopamine neurons.;Our genome-wide Foxa1-bound cis-regulatory sequences from ChIP-Seq and Foxa1/2 candidate target genes from RNA-Seq analyses of embryonic midbrain dopamine cells also provide an excellent resource for probing mechanistic insights into gene regulatory networks involved in the differentiation of midbrain dopamine neurons.;Our genome-wide Foxa1-bound cis-regulatory sequences from ChIP-Seq and Foxa1/2 candidate target genes from RNA-Seq analyses of embryonic midbrain dopamine cells also provide an excellent resource for probing mechanistic insights into gene regulatory networks involved in the differentiation of midbrain dopamine neurons.;Our genome-wide Foxa1-bound cis-regulatory sequences from ChIP-Seq and Foxa1/2 candidate target genes from RNA-Seq analyses of embryonic midbrain dopamine cells also provide an excellent resource for probing mechanistic insights into gene regulatory networks involved in the differentiation of midbrain dopamine neurons.;Our genome-wide Foxa1-bound cis-regulatory sequences from ChIP-Seq and Foxa1/2 candidate target genes from RNA-Seq analyses of embryonic midbrain dopamine cells also provide an excellent resource for probing mechanistic insights into gene regulatory networks involved in the differentiation of midbrain dopamine neurons.;Our genome-wide Foxa1-bound cis-regulatory sequences from ChIP-Seq and Foxa1/2 candidate target genes from RNA-Seq analyses of embryonic midbrain dopamine cells also provide an excellent resource for probing mechanistic insights into gene regulatory networks involved in the differentiation of midbrain dopamine neurons.;Our genome-wide Foxa1-bound cis-regulatory sequences from ChIP-Seq and Foxa1/2 candidate target genes from RNA-Seq analyses of embryonic midbrain dopamine cells also provide an excellent resource for probing mechanistic insights into gene regulatory networks involved in the differentiation of midbrain dopamine neurons.;Our genome-wide Foxa1-bound cis-regulatory sequences from ChIP-Seq and Foxa1/2 candidate target genes from RNA-Seq analyses of embryonic midbrain dopamine cells also provide an excellent resource for probing mechanistic insights into gene regulatory networks involved in the differentiation of midbrain dopamine neurons.;Our genome-wide Foxa1-bound cis-regulatory sequences from ChIP-Seq and Foxa1/2 candidate target genes from RNA-Seq analyses of embryonic midbrain dopamine cells also provide an excellent resource for probing mechanistic insights into gene regulatory networks involved in the differentiation of midbrain dopamine neurons.

About Function

Enhancer function : --
Enhancer function experiment: --
Enhancer function
experiment description:		 --

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
Foxa1 AndrogenReceptor netpath 167
Foxa1 Direct p53 effectors pid 141
Foxa1 FOXA1 transcription factor network pid 45
Foxa1 FOXA2 and FOXA3 transcription factor networks pid 45
Foxa1 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
Foxa2 FOXA1 transcription factor network pid 45
Foxa2 FOXA2 and FOXA3 transcription factor networks pid 45
Foxa2 Hedgehog signaling events mediated by Gli proteins pid 49
Foxa2 Regulation of gene expression in beta cells reactome 17
Foxa2 Maturity onset diabetes of the young kegg 25
Foxa2 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
Foxa2 Hs_Dopaminergic_Neurogenesis_WP2855_87239 wikipathways 19
Foxa2 Hs_Heart_Development_WP1591_90186 wikipathways 28
Foxa2 Hs_Ectoderm_Differentiation_WP2858_89329 wikipathways 56
Foxa1 AndrogenReceptor netpath 167
Foxa1 Direct p53 effectors pid 141
Foxa1 FOXA1 transcription factor network pid 45
Foxa1 FOXA2 and FOXA3 transcription factor networks pid 45
Foxa1 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
Foxa2 FOXA1 transcription factor network pid 45
Foxa2 FOXA2 and FOXA3 transcription factor networks pid 45
Foxa2 Hedgehog signaling events mediated by Gli proteins pid 49
Foxa2 Regulation of gene expression in beta cells reactome 17
Foxa2 Maturity onset diabetes of the young kegg 25
Foxa2 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
Foxa2 Hs_Dopaminergic_Neurogenesis_WP2855_87239 wikipathways 19
Foxa2 Hs_Heart_Development_WP1591_90186 wikipathways 28
Foxa2 Hs_Ectoderm_Differentiation_WP2858_89329 wikipathways 56
Foxa1 AndrogenReceptor netpath 167
Foxa1 Direct p53 effectors pid 141
Foxa1 FOXA1 transcription factor network pid 45
Foxa1 FOXA2 and FOXA3 transcription factor networks pid 45
Foxa1 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
Foxa2 FOXA1 transcription factor network pid 45
Foxa2 FOXA2 and FOXA3 transcription factor networks pid 45
Foxa2 Hedgehog signaling events mediated by Gli proteins pid 49
Foxa2 Regulation of gene expression in beta cells reactome 17
Foxa2 Maturity onset diabetes of the young kegg 25
Foxa2 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
Foxa2 Hs_Dopaminergic_Neurogenesis_WP2855_87239 wikipathways 19
Foxa2 Hs_Heart_Development_WP1591_90186 wikipathways 28
Foxa2 Hs_Ectoderm_Differentiation_WP2858_89329 wikipathways 56
Foxa1 AndrogenReceptor netpath 167
Foxa1 Direct p53 effectors pid 141
Foxa1 FOXA1 transcription factor network pid 45
Foxa1 FOXA2 and FOXA3 transcription factor networks pid 45
Foxa1 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
Foxa2 FOXA1 transcription factor network pid 45
Foxa2 FOXA2 and FOXA3 transcription factor networks pid 45
Foxa2 Hedgehog signaling events mediated by Gli proteins pid 49
Foxa2 Regulation of gene expression in beta cells reactome 17
Foxa2 Maturity onset diabetes of the young kegg 25
Foxa2 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
Foxa2 Hs_Dopaminergic_Neurogenesis_WP2855_87239 wikipathways 19
Foxa2 Hs_Heart_Development_WP1591_90186 wikipathways 28
Foxa2 Hs_Ectoderm_Differentiation_WP2858_89329 wikipathways 56
Foxa1 AndrogenReceptor netpath 167
Foxa1 Direct p53 effectors pid 141
Foxa1 FOXA1 transcription factor network pid 45
Foxa1 FOXA2 and FOXA3 transcription factor networks pid 45
Foxa1 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
Foxa2 FOXA1 transcription factor network pid 45
Foxa2 FOXA2 and FOXA3 transcription factor networks pid 45
Foxa2 Hedgehog signaling events mediated by Gli proteins pid 49
Foxa2 Regulation of gene expression in beta cells reactome 17
Foxa2 Maturity onset diabetes of the young kegg 25
Foxa2 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
Foxa2 Hs_Dopaminergic_Neurogenesis_WP2855_87239 wikipathways 19
Foxa2 Hs_Heart_Development_WP1591_90186 wikipathways 28
Foxa2 Hs_Ectoderm_Differentiation_WP2858_89329 wikipathways 56
Foxa1 AndrogenReceptor netpath 167
Foxa1 Direct p53 effectors pid 141
Foxa1 FOXA1 transcription factor network pid 45
Foxa1 FOXA2 and FOXA3 transcription factor networks pid 45
Foxa1 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
Foxa2 FOXA1 transcription factor network pid 45
Foxa2 FOXA2 and FOXA3 transcription factor networks pid 45
Foxa2 Hedgehog signaling events mediated by Gli proteins pid 49
Foxa2 Regulation of gene expression in beta cells reactome 17
Foxa2 Maturity onset diabetes of the young kegg 25
Foxa2 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
Foxa2 Hs_Dopaminergic_Neurogenesis_WP2855_87239 wikipathways 19
Foxa2 Hs_Heart_Development_WP1591_90186 wikipathways 28
Foxa2 Hs_Ectoderm_Differentiation_WP2858_89329 wikipathways 56
Foxa1 AndrogenReceptor netpath 167
Foxa1 Direct p53 effectors pid 141
Foxa1 FOXA1 transcription factor network pid 45
Foxa1 FOXA2 and FOXA3 transcription factor networks pid 45
Foxa1 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
Foxa2 FOXA1 transcription factor network pid 45
Foxa2 FOXA2 and FOXA3 transcription factor networks pid 45
Foxa2 Hedgehog signaling events mediated by Gli proteins pid 49
Foxa2 Regulation of gene expression in beta cells reactome 17
Foxa2 Maturity onset diabetes of the young kegg 25
Foxa2 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
Foxa2 Hs_Dopaminergic_Neurogenesis_WP2855_87239 wikipathways 19
Foxa2 Hs_Heart_Development_WP1591_90186 wikipathways 28
Foxa2 Hs_Ectoderm_Differentiation_WP2858_89329 wikipathways 56
Foxa1 AndrogenReceptor netpath 167
Foxa1 Direct p53 effectors pid 141
Foxa1 FOXA1 transcription factor network pid 45
Foxa1 FOXA2 and FOXA3 transcription factor networks pid 45
Foxa1 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
Foxa2 FOXA1 transcription factor network pid 45
Foxa2 FOXA2 and FOXA3 transcription factor networks pid 45
Foxa2 Hedgehog signaling events mediated by Gli proteins pid 49
Foxa2 Regulation of gene expression in beta cells reactome 17
Foxa2 Maturity onset diabetes of the young kegg 25
Foxa2 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
Foxa2 Hs_Dopaminergic_Neurogenesis_WP2855_87239 wikipathways 19
Foxa2 Hs_Heart_Development_WP1591_90186 wikipathways 28
Foxa2 Hs_Ectoderm_Differentiation_WP2858_89329 wikipathways 56
Foxa1 AndrogenReceptor netpath 167
Foxa1 Direct p53 effectors pid 141
Foxa1 FOXA1 transcription factor network pid 45
Foxa1 FOXA2 and FOXA3 transcription factor networks pid 45
Foxa1 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
Foxa2 FOXA1 transcription factor network pid 45
Foxa2 FOXA2 and FOXA3 transcription factor networks pid 45
Foxa2 Hedgehog signaling events mediated by Gli proteins pid 49
Foxa2 Regulation of gene expression in beta cells reactome 17
Foxa2 Maturity onset diabetes of the young kegg 25
Foxa2 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
Foxa2 Hs_Dopaminergic_Neurogenesis_WP2855_87239 wikipathways 19
Foxa2 Hs_Heart_Development_WP1591_90186 wikipathways 28
Foxa2 Hs_Ectoderm_Differentiation_WP2858_89329 wikipathways 56

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs