About Enhancer
| Enhancer ID: | E_02_0876 |
| Species: | human |
| Position : | chr17:6285838-6586838   |
| Biosample name: | |
| Experiment class : | Low throughput |
| Enhancer type: | Enhancer |
| Disease: | Steatosis |
| Pubmed ID: | 25628225 |
| Enhancer experiment: | Luciferase Reporter Assay,EMSA,ChIP |
| Enhancer experiment description: | Utilizing cell-based Luciferaseassays,electrophoretic mobility shift assays,and Chromatin immunoprecipitation assays,we identified and functionally characterized two Enhancer modules located upstream of the SLC13A5 gene transcription start site that are associated with regulation of PXR-mediated SLC13A5 induction. |
About Target gene
| Target gene : | SLC13A5(EIEE25,INDY,NACT,mIndy) |
| Strong evidence: | -- |
| Less strong evidence: | Luciferase Reporter Assay,EMSA,ChIP |
| Target gene experiment description: | Utilizing cell-based Luciferaseassays,electrophoretic mobility shift assays,and Chromatin immunoprecipitation assays,we identified and functionally characterized two Enhancer modules located upstream of the SLC13A5 gene transcription start site that are associated with regulation of PXR-mediated SLC13A5 induction. |
About TF
| TF name : | NR1I2(BXR,ONR1,PAR,PAR1,PAR2,PARq,PRR,PXR,SAR,SXR) |
| TF experiment: | EMSA |
| TF experiment description: | Utilizing in vitro EMSA,we found that heterodimer of PXR and the retinoid X receptor binds specifically to DR4-1 and DR4-2 at intensities equal to or exceeding that of the everted-repeat (ER6) element from CYP3A4 promoter. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NR1I2 | Nuclear Receptor transcription pathway | reactome | 51 |
| NR1I2 | Hs_Drug_Induction_of_Bile_Acid_Pathway_WP2289_88593 | wikipathways | 9 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene