About Enhancer
| Enhancer ID: | E_02_0878 |
| Species: | human |
| Position : | chr12:3944001-3947078   |
| Biosample name: | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 25605944 |
| Enhancer experiment: | ChIP-seq,3C,ChIP |
| Enhancer experiment description: | Further, we have defined the subset of the enhancers that have active chromatin markers (H3K27ac and p300).Motif enrichment analysis of H3K27ac+ p300+ enhancers revealed enrichment of binding sites for the CCCTC-binding factor (CTCF), neurofibromin 1 (NF1), bHLH, FORKHEAD, X-BOX,and T-BOX families of transcription factors. Although members of the CTCF and NF1 family are general cellular transcription factors, the factors in the bHLH and other families may be critical for lineage development and enhancer programming in corticotropes. |
About Target gene
| Target gene : | Pomc(ACTH,BE,Beta-LPH,Clip,Gamma-LPH,Npp-1,Pomc1,alpha-MSH,alphaMSH,beta-MSH,gamma-MSH,Pomc) |
| Strong evidence: | 3C,CRISPR/Cas9 |
| Less strong evidence: | qPCR,ChIP,GRO-seq |
| Target gene experiment description: | We found that enhancer:promoter interactions between LDB1-bound enhancers and the adjacent promoters of POMC and lung carcinoma myc related oncogene 1 (Lmyc1) genes were greatly diminished following knockdown of Ldb1. |
About TF
| TF name : | -- |
| TF experiment: | -- |
| TF experiment description: | -- |
About Function
| Enhancer function : | LDB1-mediated enhancer:promoter looping appears to be required for both activation and repression of these target genes |
| Enhancer function experiment: | qPCR,3C,GRO-seq |
| Enhancer function experiment description: |
Together,our data reveal that Enhancer-bound LDB1 has a role in mediating the actions of both activating and repressive Enhancers in a cell type_x0002_specific gene-regulation program. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene