About Enhancer
| Enhancer ID: | E_02_0880 |
| Species: | mouse |
| Position : | chr10:62893206-62923461   |
| Biosample name: | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Super-Enhancer |
| Disease: | -- |
| Pubmed ID: | 25582196 |
| Enhancer experiment: | ChIP-seq,Luciferase Reporter Assay |
| Enhancer experiment description: | To identify cis-regulatory elements in Tet1, we surveyed its epigenome in mouse ESCs using ChIP-seq data sets.The combinatorial binding profiles of pluripotency factors, Mediator,and cohesin units have previously delineated a superenhancer domain in Tet1, a 15.2-kb region that spans from exon 1c at the distal end to a conserved noncoding sequence (CNS) upstream of the CDS ChIP-seq showed strong binding profiles of Oct4 within the CNS,as previously shown, but also several more strong peaks in the distal region between exons 1b and 1c. |
About Target gene
| Target gene : | Tet1(2510010B09Rik,AA517754,BB001228,Cxxc6,D10Ertd17e,LCX,mKIAA1676),Tet1(2510010B09Rik,AA517754,BB001228,Cxxc6,D10Ertd17e,LCX,mKIAA1676) |
| Strong evidence: | -- |
| Less strong evidence: | PCR,EMSA |
| Target gene experiment description: | Here we defined the promoter and Enhancer domains in Tet1 and Tet2.Within a 15- superEnhancer of Tet1,there are two transcription start sites (TSSs) with different activation patterns during development.;Here we defined the promoter and Enhancer domains in Tet1 and Tet2.Within a 15- superEnhancer of Tet1,there are two transcription start sites (TSSs) with different activation patterns during development. |
About TF
| TF name : | Oct4Sox2(ANOP3,MCOPS3)Oct4Sox2(ANOP3,MCOPS3) |
| TF experiment: | EMSA |
| TF experiment description: | Contribution of Oct and Sox motifs in Tet1 and Tet2 enhancer fragments.;Contribution of Oct and Sox motifs in Tet1 and Tet2 enhancer fragments. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene