About Enhancer
| Enhancer ID: | E_02_0900 |
| Species: | human |
| Position : | chr9:124638991-124641160   |
| Biosample name: | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 24916375 |
| Enhancer experiment: | ChIP-seq,ChIP-qPCR |
| Enhancer experiment description: | We profiled the chromatin structure of the BNC2 region to identify potential regulatory elements using chromatin immune-precipitation (ChIP) of H3K27Ac (an active-enhancer mark) in combination with next generation sequencing (ChIP-seq) and ENCODE data. We provide evidence that a region upstream from the canonical BNC2 promoter acts as an enhancer regulating the expression of BNC2, and this transcriptional regulation is dependent on the allelic status of an LD partner of the pigmentation-associated SNP rs10756819. |
About Target gene
| Target gene : | BNC2(BSN2) |
| Strong evidence: | -- |
| Less strong evidence: | ChIP-seq,RT-qPCR |
| Target gene experiment description: | We confirmed this finding by RTqPCR analysis ofBNC2-expression levels atthree different loca_x0002_tions within the gene, using one primer set targeting mRNA upstream of the alternative promoter, and two primer sets targeting the mRNA downstream of the alternative promoter. |
About TF
| TF name : | -- |
| TF experiment: | -- |
| TF experiment description: | -- |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene