About Enhancer
| Enhancer ID: | E_02_0903 |
| Species: | human |
| Position : | chr16:86212040-86271919   |
| Biosample name: | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Super-Enhancer |
| Disease: | -- |
| Pubmed ID: | 24842713 |
| Enhancer experiment: | ChIP-seq,qRT-PCR,ChIP-qPCR |
| Enhancer experiment description: | Using chromatin immunoprecipitation with high-throughput sequencing (ChIP-seq) of histone H3K27 acetylation (H3K27ac), a mark of active enhancers,we first identified enhancer regions in MYCN-amplified Kelly and nonamplified SH-SY5Y cells. |
About Target gene
| Target gene : | FOXF1(ACDMPV,FKHL5,FREAC1) |
| Strong evidence: | -- |
| Less strong evidence: | shRNA |
| Target gene experiment description: | Here we investigate whether inhibition of transcriptional CDKs can be exploited to disrupt aberrant MYC-driven transcription, using the deregulated expression of MYCN as a model. The MYCN protein shares most of the physical properties of MYC and is considered functionally interchangeable, based on the similarity of their transcriptional programs, the cellular phenotypes they induce, and the ability of MYCN to replace MYC during murine development. |
About TF
| TF name : | MITF(CMM8,COMMAD,MI,WS2,WS2A,bHLHe32)YY1(DELTA,GADEVS,INO80S,NF-E1,UCRBP,YIN-YANG-1) |
| TF experiment: | ChIP-qPCR |
| TF experiment description: | Binding of RNA Polymerase II, similarly tested with ChIP-qPCR in LP89, is relatively high at the alternative promoter and region B??, which has several features consistent with an enhancer element, e.g. high H3K27Ac enrichment low H3K4Me3 enrichment and binding of MITF and YY1. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene