About Enhancer
| Enhancer ID: | E_02_0916 |
| Species: | human |
| Position : | chr6:52296135-52334522   |
| Biosample name: | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 24385922 |
| Enhancer experiment: | ChIP,PCR,3C,5C,ChIP-seq |
| Enhancer experiment description: | Sequences distinct from proximal promoters (RefSeq) that were bound by RNAP2 and at least one other mark, or by both p300 and H3K27Ac were retained as candidate enhancers. Using these criteria, 19 putative enhancers were identified within 850 kb upstream of Hoxa13. |
About Target gene
| Target gene : | Hoxa(Hox-1) |
| Strong evidence: | 3C |
| Less strong evidence: | PCR |
| Target gene experiment description: | Here,we report on the first identification of bona fide transcriptional Enhancers controlling HoxA genes in developing limbs and show that these Enhancers are grouped into distinct topological domains at the sub-megabase scale. |
About TF
| TF name : | Ctcf(MRD21) |
| TF experiment: | 5C |
| TF experiment description: | Interestingly,loci bound either by CTCF or cohesin in limb buds have been recently identified and comparison with our data shows that almost all loci interacting with 59 HoxA genes overlap with either CTCF o cohesin binding. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Ctcf | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| Ctcf | TGF_beta_Receptor | netpath | 220 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene