About Enhancer
| Enhancer ID: | E_02_0917 |
| Species: | mouse |
| Position : | chr15:37116298-37122452   |
| Biosample name: | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 24374176 |
| Enhancer experiment: | ChIP-qPCR,ChIP-seq,ChIP |
| Enhancer experiment description: | Based on these results, we identified sequence d as a MB Meis2 enhancer, and hereafter designate it as MBE. We went on to look for accumulation of histone H3K27 acetylation (H3K27ac) and H3K4 monomethylation (H3K4me1), which demarcate active and potential enhancers, respectively, at MBE by ChIP-seq. |
About Target gene
| Target gene : | MEIS2(CPCMR,HsT18361,MRG1) |
| Strong evidence: | -- |
| Less strong evidence: | ChIP-qPCR,ChIP-seq |
| Target gene experiment description: | In wild-type mice, Meis2 showed distinctive expres_x0002_sion patterns at 11.5 dpc in FB, MB, pharyngeal arches, spinal cord, neural crest, and somites. In Ring1 mutants, however,we found atypical derepression of Meis2 in facial and cephalic mesenchyme, heart primordium, LM, and somatic mesoderm,coupled with its downregulation in FB and MB (Figure 1C). These results indicate that PcG is involved in both repression and activation of Meis2 in a tissue-specific manner. |
About TF
| TF name : | RNF2(BAP-1,BAP1,DING,HIPI3,RING1B,RING2) |
| TF experiment: | ChIP-qPCR,ChIP-seq |
| TF experiment description: | RING1B ChIP-seq data (GSE48464) over 10 Mb of the mouse genome (mm9) around Meis2 in FB,MB, and LM at 11.5 dpc.Binding of H3K27ac and RING1B in 11.5 dpc MB of WT and Ring1 mutant (Ring1 mut) revealed by ChIP-quantitative PCR (ChIP-qPCR) analysis. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| RNF2 | Oxidative Stress Induced Senescence | reactome | 120 |
| RNF2 | SUMOylation of DNA damage response and repair proteins | reactome | 76 |
| RNF2 | SUMOylation of RNA binding proteins | reactome | 46 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene