About Enhancer
| Enhancer ID: |
E_02_0927 |
| Species: |
mouse |
| Position :
|
chr17:40206839-40206900
  |
| Biosample name: |
|
| Experiment class :
|
Low throughput |
| Enhancer type: |
Enhancer |
| Disease: |
-- |
| Pubmed ID: |
24000349
|
| Enhancer experiment: |
ChIP,qRT-PCR |
| Enhancer experiment description: |
This reflects the fact that both the human and mouse Pgk2 gene promoters contain highly conserved regulatory elements including a GC-box, a CAAT-box and an enhancer region just upstream from the CAAT-box. |
About Target gene
| Target gene : |
Pgk2(Pgk-2,Tcp-2) |
| Strong evidence: |
-- |
| Less strong evidence: |
ChIP,qRT-PCR |
| Target gene experiment description: |
Our results indicate there is an ordered series of molecular events that lead to activation of transcription of the Pgk2 gene in spermatogenic cells, and that these events are signaled by distinct elements in the Pgk2 promoter/Enhancer region. |
About TF
| TF name : |
-- |
| TF experiment: |
-- |
| TF experiment description: |
-- |
About Function
| Enhancer function : |
Activation of Pgk2 transcription is regulated by testis-specific demethylation of DNA and binding of testis-specific transcription factors to Enhancer and core promoter elements. |
| Enhancer function experiment: |
ChIP,qRT-PCR |
Enhancer function
experiment description: |
Our results indicate there is an ordered series of molecular events that lead to activation of transcription of the Pgk2 gene in spermatogenic cells, and that these events are signaled by distinct elements in the Pgk2 promoter/Enhancer region. |
About SNP
Upstream Pathway Annotation of TF
| GeneName |
Pathway Name |
Source |
Gene Number |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene
Expression of target genes for the
enhancer
Enhancer associated SNPs