About Enhancer

Enhancer ID: E_02_0933
Species: human
Position : chr11:69468873-69470873
Biosample name:
Experiment class : Low throughput
Enhancer type: Enhancer
Disease: Breast tumor
Pubmed ID:  23637611
Enhancer experiment: ChIP,PCR,3C
Enhancer experiment description: Long-range chromatin interactions between ERa recognition sequences and enhancers have been proposed to regulate ERa target genes in breast cancer cells. The main enhancer regulating CCND1 is located at the 39 end of the gene, 14 kb distant from the promoter.

About Target gene

Target gene : CCND1(BCL1,D11S287E,PRAD1,U21B31)
Strong evidence: 3C
Less strong evidence: PCR
Target gene experiment description: The main Enhancer regulating CCND1 is located at the 3' end of the gene,14 kb distant from the promoter.

About TF

TF name : KAT5(ESA1,HTATIP,HTATIP1,PLIP,TIP,TIP60,ZC2HC5,cPLA2)
TF experiment: ChIP
TF experiment description: TIP60 binding to the CCND1 promoter was analyzed by ChIP and shown as percent of input (n = 2).

About Function

Enhancer function : --
Enhancer function experiment: --
Enhancer function
experiment description:
--

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
KAT5 Alzheimer disease-amyloid secretase pathway panther 56
KAT5 Alzheimer disease-presenilin pathway panther 98
KAT5 AndrogenReceptor netpath 167
KAT5 ATF-2 transcription factor network pid 59
KAT5 ATM pathway pid 34
KAT5 C-MYC pathway pid 25
KAT5 DNA Damage/Telomere Stress Induced Senescence reactome 64
KAT5 Formation of the beta-catenin:TCF transactivating complex reactome 88
KAT5 G2/M DNA damage checkpoint reactome 84
KAT5 HATs acetylate histones reactome 142
KAT5 HDR through Homologous Recombination (HRR) reactome 46
KAT5 HDR through Single Strand Annealing (SSA) reactome 37
KAT5 Homologous DNA Pairing and Strand Exchange reactome 25
KAT5 IL9 netpath 24
KAT5 Nonhomologous End-Joining (NHEJ) reactome 69
KAT5 p53 pathway pid 59
KAT5 p73 transcription factor network pid 80
KAT5 Presynaptic phase of homologous DNA pairing and strand exchange reactome 39
KAT5 Processing of DNA double-strand break ends reactome 98
KAT5 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks reactome 75
KAT5 Regulation of Androgen receptor activity pid 54
KAT5 Regulation of TP53 Activity through Phosphorylation reactome 89
KAT5 Resolution of D-loop Structures through Holliday Junction Intermediates reactome 33
KAT5 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) reactome 26
KAT5 Sensing of DNA Double Strand Breaks reactome 6
KAT5 Validated targets of C-MYC transcriptional activation pid 80
KAT5 Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 wikipathways 50

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer


Enhancer associated SNPs