About Enhancer
| Enhancer ID: | E_02_0938 |
| Species: | human |
| Position : | chr11:8301851-8303851   |
| Biosample name: | |
| Experiment class : | Low throughput |
| Enhancer type: | Enhancer |
| Disease: | T-cell leukemia |
| Pubmed ID: | 23302769 |
| Enhancer experiment: | ChIP,RT-PCR,Luciferase Reporter Assay |
| Enhancer experiment description: | The LMO1 promoters display bivalent histone marks in multiple blood lineages including T-cells, and a 3 flanking region at LMO1 ? 57 contains a transcriptional enhancer that is active in developing blood cells in transgenic mouse embryos. The LMO1 promoters become activated in T-ALL together with the 3 enhancer, which is bound in primary T-ALL cells by SCL/TAL1 and GATA3. |
About Target gene
| Target gene : | LMO1(RBTN1,RHOM1,TTG1) |
| Strong evidence: | -- |
| Less strong evidence: | ChIP,RT-PCR,Luciferase Reporter Assay |
| Target gene experiment description: | To investigate whether lack of expres_x0002_sion in the haematopoietic system may be due to active repression of the two LMO1 promoters, we analysed ChIP-Sequencing data released to the public domain by the NIH Roadmap Epigeno_x0002_mics Mapping Project. |
About TF
| TF name : | TAL1(SCL,TCL5,bHLHa17,tal-1)GATA3(HDR,HDRS) |
| TF experiment: | ChIP,qPCR |
| TF experiment description: | ChIP assays on T-ALL cells from the same primagraft (X31) using antibodies against SCL/TAL1and GATA3. Analysis by quantitative PCR demonstrates significant binding of both SCL/TAL1 and GATA3 to the LMO1 +57 enhancer, with no binding to either of the two LMO1 promoters. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA3 | C-MYB transcription factor network | pid | 87 |
| GATA3 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| GATA3 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA3 | Glucocorticoid receptor regulatory network | pid | 85 |
| GATA3 | IL27-mediated signaling events | pid | 26 |
| GATA3 | Notch signaling pathway | pid | 58 |
| GATA3 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| GATA3 | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| GATA3 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene