About Enhancer

Enhancer ID: E_02_0941
Species: human
Position : chr1:60908875-60908895
Biosample name:
Experiment class : Low throughput
Enhancer type: Enhancer
Disease: --
Pubmed ID:  23024062
Enhancer experiment: Luciferase Reporter Assay
Enhancer experiment description: T cells were stimulated with CPT after transfection of CTLA4 luciferase reporter constructs (including -1221, -343, -238, -167, and-63 bp relative to the CTLA4 transcription start site). suggesting the presence of an enhancer binding site in this region.

About Target gene

Target gene : Ctla4(Cd152,Ctla-4,Ly-56)
Strong evidence: --
Less strong evidence: ChIP
Target gene experiment description: The promoter region from 2150 to 2130 bp contains a putative CREB binding site, a well known downstream transcription factor of cAMP signaling. To define whether the putative CREB binding site (2150 to 2143 bp) is responsive to cAMP, we performed ChIP assay with CREB antibody in T cells, with or without CPT treatment.

About TF

TF name : Creb1(2310001E10Rik,3526402H21Rik,AV083133,Creb,Creb-1)
TF experiment: ChIP
TF experiment description: The promoter region from -150 to -130 bp contains a putative CREB binding site, a well known downstream transcription factor of cAMP signaling.

About Function

Enhancer function : --
Enhancer function experiment: --
Enhancer function
experiment description:		 --

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
Creb1 AKT phosphorylates targets in the nucleus reactome 9
Creb1 AndrogenReceptor netpath 167
Creb1 AP-1 transcription factor network pid 71
Creb1 ATF-2 transcription factor network pid 59
Creb1 BCR netpath 161
Creb1 BMAL1:CLOCK,NPAS2 activates circadian gene expression reactome 42
Creb1 CaMK IV-mediated phosphorylation of CREB reactome 5
Creb1 Circadian Clock reactome 49
Creb1 Constitutive Signaling by AKT1 E17K in Cancer reactome 25
Creb1 CREB phosphorylation reactome 7
Creb1 CREB phosphorylation through the activation of Adenylate Cyclase reactome 7
Creb1 CREB phosphorylation through the activation of CaMKII reactome 17
Creb1 CREB phosphorylation through the activation of CaMKK reactome 6
Creb1 CREB phosphorylation through the activation of Ras reactome 13
Creb1 EGFR1 netpath 475
Creb1 Enkephalin release panther 17
Creb1 ErbB1 downstream signaling pid 105
Creb1 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin smpdb 7
Creb1 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin smpdb 7
Creb1 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin smpdb 7
Creb1 FOXA2 and FOXA3 transcription factor networks pid 45
Creb1 FSH netpath 44
Creb1 Gastrin-CREB signalling pathway via PKC and MAPK reactome 9
Creb1 Glucocorticoid receptor regulatory network pid 85
Creb1 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway panther 126
Creb1 Heterotrimeric GPCR signaling pathway (through Adenosine G alpha s) ( GPCR Adenosine A2A receptor signaling pathway ) inoh 9
Creb1 Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s) ( GPCR Dopamine D1like receptor signaling pathway ) inoh 45
Creb1 HIF-1-alpha transcription factor network pid 67
Creb1 IL2 netpath 81
Creb1 IL3 netpath 84
Creb1 Integrin-linked kinase signaling pid 46
Creb1 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine smpdb 37
Creb1 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine smpdb 38
Creb1 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone smpdb 10
Creb1 Intracellular Signalling Through Histamine H2 Receptor and Histamine smpdb 8
Creb1 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin smpdb 10
Creb1 Leptin netpath 98
Creb1 LKB1 signaling events pid 43
Creb1 LPA4-mediated signaling events pid 16
Creb1 NCAM signaling for neurite out-growth reactome 22
Creb1 Nongenotropic Androgen signaling pid 31
Creb1 NOTCH2 intracellular domain regulates transcription reactome 12
Creb1 p38 signaling mediated by MAPKAP kinases pid 21
Creb1 RANKL netpath 84
Creb1 Regulation of nuclear SMAD2/3 signaling pid 82
Creb1 Signaling events regulated by Ret tyrosine kinase pid 39
Creb1 Signaling mediated by p38-alpha and p38-beta pid 35
Creb1 TCR netpath 261
Creb1 TNFalpha netpath 274
Creb1 Transcriptional activation of mitochondrial biogenesis reactome 43
Creb1 Trk receptor signaling mediated by PI3K and PLC-gamma pid 36
Creb1 Trk receptor signaling mediated by the MAPK pathway pid 34
Creb1 TSH netpath 82
Creb1 Validated targets of C-MYC transcriptional repression pid 63
Creb1 VEGFR3 signaling in lymphatic endothelium pid 26
Creb1 Antigen processing and presentation kegg 75
Creb1 Melanogenesis kegg 100
Creb1 Vasopressin-regulated water reabsorption kegg 35
Creb1 Huntington's disease kegg 182
Creb1 Prostate cancer kegg 85

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs