About Enhancer
| Enhancer ID: | E_02_0964 |
| Species: | human |
| Position : | chr11:44390342-44392251   |
| Biosample name: | |
| Experiment class : | Low throughput |
| Enhancer type: | Enhancer |
| Disease: | Autoimmune and inflammatory diseases |
| Pubmed ID: | 21566115 |
| Enhancer experiment: | Luciferase Reporter Assay,qRT-PCR |
| Enhancer experiment description: | We focused on a conserved enhancer about 10kb upstream of the Il12b start site that is targeted by TLR signaling to increase Il12b transcription in response to LPS (33). We made luciferase reporter constructs that fused the Il12b promoter to the upstream enhancer. |
About Target gene
| Target gene : | Il12b(CLMF,CLMF2,IL-12B,IMD28,IMD29,NKSF,NKSF2) |
| Strong evidence: | -- |
| Less strong evidence: | Luciferase Reporter Assay,qRT-PCR |
| Target gene experiment description: | To search for transcription factors that could be involved in the suppression of Il12b transcription, we used qRT-PCR to measure the expression of transcription factor mRNAs induced by IL-10 in the presence of an inflammatory costimulus.We made luciferase reporter constructs that fused the Il12b promoter to the upstream enhancer. |
About TF
| TF name : | Nfil3(AV225605,E4BP4) |
| TF experiment: | qRT-PCR,Luciferase Reporter Assay |
| TF experiment description: | A NFIL3 binding site is identified in the enhancer region of Il12b. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene