About Enhancer

Enhancer ID: E_02_0965
Species: human
Position : chr20:44430820-44433428
Biosample name:
Experiment class : Low throughput
Enhancer type: Enhancer
Disease: Prostate cancer
Pubmed ID:  21556051
Enhancer experiment: RT-PCR,Luciferase Reporter Assay,ChIP,3C
Enhancer experiment description: we performed quantitative 3C assays for the UBE2C locus in LNCaP and PC-3 cells, in order to identify potential PC-3-specific UBE2C enhancers.

About Target gene

Target gene : UBE2C(UBCH10,dJ447F3.2)
Strong evidence: 3C
Less strong evidence: RT-PCR,Western blot
Target gene experiment description: 3C assays were performed at the UBE2C locus to measure crosslinking frequencies between PC-3-specific UBE2C enhancers and the UBE2C promoter

About TF

TF name : FOXA1(HNF3A,TCF3A)GATA2(DCML,IMD21,MONOMAC,NFE1B)POU2F1(OCT1,OTF1,oct-1B)ETS1(ETS-1,EWSR2,c-ets-1,p54)
TF experiment: ChIP
TF experiment description: To examine whether these transcription factors were differentially recruited to E1,E2 and E3 on chromatin, chromatin immunoprecipitation (ChIP) assays were performed using specific antibodies against FoxA1, GATA2, Oct1 and ETS1 in LNCaP and PC-3 cells treated with or without DHT.

About Function

Enhancer function : --
Enhancer function experiment: --
Enhancer function
experiment description:		 --

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
FOXA1 AndrogenReceptor netpath 167
FOXA1 Direct p53 effectors pid 141
FOXA1 FOXA1 transcription factor network pid 45
FOXA1 FOXA2 and FOXA3 transcription factor networks pid 45
FOXA1 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
GATA2 AP-1 transcription factor network pid 71
GATA2 Factors involved in megakaryocyte development and platelet production reactome 111
GATA2 HIF-1-alpha transcription factor network pid 67
GATA2 IL3 netpath 84
GATA2 Regulation of Androgen receptor activity pid 54
GATA2 Signaling events mediated by HDAC Class I pid 89
GATA2 Signaling events mediated by HDAC Class II pid 58
GATA2 Hs_Apoptosis_WP254_88977 wikipathways 31
POU2F1 AndrogenReceptor netpath 167
POU2F1 ATF-2 transcription factor network pid 59
POU2F1 Calcineurin-regulated NFAT-dependent transcription in lymphocytes pid 50
POU2F1 Calcium signaling in the CD4+ TCR pathway pid 29
POU2F1 FOXA1 transcription factor network pid 45
POU2F1 Glucocorticoid receptor regulatory network pid 85
POU2F1 Regulation of Androgen receptor activity pid 54
POU2F1 RNA polymerase II transcribes snRNA genes reactome 70
POU2F1 RNA Polymerase III Abortive And Retractive Initiation reactome 41
POU2F1 RNA Polymerase III Transcription Initiation From Type 3 Promoter reactome 28
POU2F1 Hs_Integrated_Cancer_Pathway_WP1971_82939 wikipathways 33
ETS1 Angiogenesis panther 141
ETS1 Angiopoietin receptor Tie2-mediated signaling pid 50
ETS1 AP-1 transcription factor network pid 71
ETS1 BCR signaling pathway pid 70
ETS1 C-MYB transcription factor network pid 87
ETS1 ERK cascade ( FGF8 signaling (Mouse) ) inoh 17
ETS1 ERK cascade ( FGF8 signaling (Xenopus) ) inoh 17
ETS1 FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) inoh 20
ETS1 FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) inoh 18
ETS1 HIF-1-alpha transcription factor network pid 67
ETS1 HIF-2-alpha transcription factor network pid 34
ETS1 IL2 netpath 81
ETS1 IL4-mediated signaling events pid 66
ETS1 IL4 netpath 75
ETS1 Oncogene Induced Senescence reactome 30
ETS1 PDGF signaling pathway panther 113
ETS1 Ras Pathway panther 69
ETS1 Signaling events mediated by focal adhesion kinase pid 63
ETS1 Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) pid 80
ETS1 TGF_beta_Receptor netpath 220
ETS1 VEGF signaling pathway panther 54
ETS1 MAPK signaling pathway - fly kegg 16
ETS1 Dorso-ventral axis formation kegg 25
ETS1 Hs_Apoptosis-related_network_due_to_altered_Notch3_in_ovarian_cancer_WP2864_79278 wikipathways 51
ETS1 Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
ETS1 Hs_Neural_Crest_Differentiation_WP2064_79263 wikipathways 40
ETS1 Hs_TGF-beta_Signaling_Pathway_WP366_90028 wikipathways 67
ETS1 Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900 wikipathways 71

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs