About Enhancer

Enhancer ID: E_02_0969
Species: human
Position : chr1:33353796-33354196
Biosample name:
Experiment class : Low throughput
Enhancer type: Enhancer
Disease: --
Pubmed ID:  21527503
Enhancer experiment: Luciferase Reporter Assay,PCR,ChIP
Enhancer experiment description: As detected by chromatin immunoprecipitation assays, treatment of cells with the progestin agonist R5020 induced a rapid recruitment (5 min) of PR to the proximal promoter (?235 bp) and distal enhancer (?6 kb upstream of transcription start site) of ?-casein

About Target gene

Target gene : TMEM54(BCLP,CAC-1,CAC1),?-casein gene
Strong evidence: --
Less strong evidence: ChIP
Target gene experiment description: In this study, we used HC-11 cells and ChIP assays to examine the influence of progesterone and PR on cooperative interactions and dynamics of the various transcription factors and coregulatory proteins that interact with the promoter and enhancer of the endogenous ?-casein gene.

About TF

TF name : STAT5B(STAT5)CEBPB(C/EBP-beta,IL6DBP,NF-IL6,TCF5)YY1(DELTA,GADEVS,INO80S,NF-E1,UCRBP,YIN-YANG-1)
TF experiment: PCR,ChIP
TF experiment description: Primers for PCR amplification of the proximal promoter span a 170-bp region (-190 to -20 from the transcription start site) containing binding sites for Stat5a,C/EBP,YY1,and GRE/progestin response element (PRE) half-sites, whereas a 400-bp region (-6400 to -6000) of the distal Enhancer was amplified that contains binding sites for Stat5,C/EBP,and other factors.

About Function

Enhancer function : --
Enhancer function experiment: --
Enhancer function
experiment description:		 --

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
STAT5B Angiopoietin receptor Tie2-mediated signaling pid 50
STAT5B CXCR4-mediated signaling events pid 87
STAT5B Downstream signal transduction reactome 29
STAT5B EGF receptor signaling pathway panther 109
STAT5B EGFR1 netpath 475
STAT5B EPO signaling pathway pid 33
STAT5B EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) inoh 12
STAT5B ErbB4 signaling events pid 35
STAT5B FGF signaling pathway pid 55
STAT5B Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 14
STAT5B Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 8
STAT5B Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 8
STAT5B Glucocorticoid receptor regulatory network pid 85
STAT5B GMCSF-mediated signaling events pid 38
STAT5B Growth hormone receptor signaling reactome 24
STAT5B Growth hormone signaling pathway(JAK2 STAT5) ( Growth hormone signaling(JAK2 STAT5) ) inoh 9
STAT5B IL-2 signaling pathway(JAK1 JAK3 STAT5) ( IL-2 signaling(JAK1 JAK3 STAT5) ) inoh 7
STAT5B IL-3 signaling pathway(JAK1 JAK2 STAT5) ( IL-3 signaling(JAK1 JAK2 STAT5) ) inoh 7
STAT5B IL-5 signaling pathway(JAK1 JAK2 STAT1 STAT5) ( IL-5 signaling(JAK1 JAK2 STAT1 STAT5) ) inoh 11
STAT5B IL-7 netpath 28
STAT5B IL-7 signaling pathway(JAK1 JAK3 STAT5) ( IL-7 signaling(JAK1 JAK3 STAT5) ) inoh 13
STAT5B IL2-mediated signaling events pid 54
STAT5B IL2 netpath 81
STAT5B IL2 signaling events mediated by STAT5 pid 30
STAT5B IL3-mediated signaling events pid 27
STAT5B IL3 netpath 84
STAT5B IL4-mediated signaling events pid 66
STAT5B IL4 netpath 75
STAT5B IL5-mediated signaling events pid 14
STAT5B IL5 netpath 59
STAT5B IL6 netpath 85
STAT5B IL9 netpath 24
STAT5B Interleukin-2 signaling reactome 14
STAT5B Interleukin-3, 5 and GM-CSF signaling reactome 24
STAT5B Interleukin-7 signaling reactome 11
STAT5B Interleukin signaling pathway panther 86
STAT5B JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 97
STAT5B JAK/STAT signaling pathway panther 15
STAT5B KitReceptor netpath 104
STAT5B Leptin netpath 98
STAT5B PDGF signaling pathway (Mammal) ( PDGF signaling pathway ) inoh 29
STAT5B PDGF signaling pathway panther 113
STAT5B PDGFR-beta signaling pathway pid 125
STAT5B Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 178
STAT5B Prolactin netpath 105
STAT5B Prolactin receptor signaling reactome 15
STAT5B Signaling by cytosolic FGFR1 fusion mutants reactome 18
STAT5B Signaling by Leptin reactome 11
STAT5B Signaling by SCF-KIT reactome 37
STAT5B Signaling events mediated by PTP1B pid 53
STAT5B Signaling events mediated by TCPTP pid 40
STAT5B TCR netpath 261
STAT5B TSLP netpath 24
STAT5B ErbB signaling pathway kegg 83
STAT5B Chemokine signaling pathway kegg 187
STAT5B Jak-STAT signaling pathway kegg 149
STAT5B Pathways in cancer kegg 321
STAT5B Chronic myeloid leukemia kegg 69
STAT5B Acute myeloid leukemia kegg 53
STAT5B Hs_Leptin_signaling_pathway_WP2034_89856 wikipathways 37
STAT5B Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 wikipathways 44
STAT5B Hs_Kit_receptor_signaling_pathway_WP304_78799 wikipathways 46
STAT5B Hs_IL-5_Signaling_Pathway_WP127_78498 wikipathways 35
STAT5B Hs_IL-2_Signaling_Pathway_WP49_91243 wikipathways 33
STAT5B Hs_Prolactin_Signaling_Pathway_WP2037_90015 wikipathways 52
STAT5B Hs_AGE-RAGE_pathway_WP2324_89798 wikipathways 27
STAT5B Hs_IL-4_Signaling_Pathway_WP395_89828 wikipathways 41
STAT5B Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 wikipathways 107
STAT5B Hs_IL-3_Signaling_Pathway_WP286_78583 wikipathways 35
STAT5B Hs_IL-7_Signaling_Pathway_WP205_89854 wikipathways 16
STAT5B Hs_IL-9_Signaling_Pathway_WP22_79264 wikipathways 11
STAT5B Hs_Insulin_signalling_in_adipocytes_(diabetic_condition)_WP3635_86059 wikipathways 6
STAT5B Hs_Insulin_signalling_in_adipocytes_(normal_condition)_WP3634_86060 wikipathways 6
CEBPB C-MYB transcription factor network pid 87
CEBPB EGFR1 netpath 475
CEBPB FOXA1 transcription factor network pid 45
CEBPB FOXA2 and FOXA3 transcription factor networks pid 45
CEBPB IFN-gamma pathway pid 43
CEBPB IL3-mediated signaling events pid 27
CEBPB IL4-mediated signaling events pid 66
CEBPB IL4 netpath 75
CEBPB IL6-mediated signaling events pid 48
CEBPB IL6 netpath 85
CEBPB RANKL netpath 84
CEBPB Regulation of nuclear SMAD2/3 signaling pid 82
CEBPB Regulation of retinoblastoma protein pid 67
CEBPB Senescence-Associated Secretory Phenotype (SASP) reactome 108
CEBPB Signaling mediated by p38-alpha and p38-beta pid 35
CEBPB TCR netpath 261
CEBPB Transcriptional regulation of white adipocyte differentiation reactome 79
CEBPB Validated nuclear estrogen receptor alpha network pid 65
CEBPB Hs_Senescence_and_Autophagy_in_Cancer_WP615_81193 wikipathways 62
CEBPB Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 wikipathways 44
CEBPB Hs_Transcriptional_activation_by_NRF2_WP3_79527 wikipathways 6
CEBPB Hs_Lung_fibrosis_WP3624_91475 wikipathways 23
CEBPB Hs_IL17_signaling_pathway_WP2112_89838 wikipathways 20
YY1 Activation of anterior HOX genes in hindbrain development during early embryogenesis reactome 120
YY1 DNA Damage Recognition in GG-NER reactome 38
YY1 E2F transcription factor network pid 77
YY1 mTOR signaling pathway pid 66
YY1 Notch-mediated HES/HEY network pid 48
YY1 Notch netpath 76
YY1 Notch signaling pathway pid 58
YY1 p53 pathway pid 59
YY1 Signaling events mediated by HDAC Class I pid 89

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs