About Enhancer
| Enhancer ID: | E_02_0982 |
| Species: | human |
| Position : | chr6:35574362-35576362   |
| Biosample name: | |
| Experiment class : | Low throughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 20093418 |
| Enhancer experiment: | RT-qPCR,ChIP |
| Enhancer experiment description: | According to our quantitative ChIP and enhancer assays, there are at least three major distal gene regions that significantly bind GR and also function as strong GR-regulated enhancers in isolation. |
About Target gene
| Target gene : | FKBP4(FKBP51,FKBP52,FKBP59,HBI,Hsp56,PPIase,p52) |
| Strong evidence: | -- |
| Less strong evidence: | ChIP,Luciferase Reporter Assay |
| Target gene experiment description: | Our quantitative chromatin immunoprecipitation scans and enhancer activity analyses indicate that activation of the FKBP51 locus by glucocorticoids in vivo is triggered by the loading of GR to enhancers at about 34 kb 5 and about 87 kb 3 of the transcription start site. |
About TF
| TF name : | CTCF(MRD21) |
| TF experiment: | ChIP |
| TF experiment description: | We used the genome-wide CTCF-binding information from the CTCF-binding site database for choosing the regions to be ChIP scanned with anti-CTCF antibody. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene