About Enhancer
| Enhancer ID: | E_02_0986 |
| Species: | mouse |
| Position : | chr5:147205131-147212149   |
| Biosample name: | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer |
| Disease: | Pancreatic hypoplasia |
| Pubmed ID: | 19141476 |
| Enhancer experiment: | ChIP,ChIP-seq |
| Enhancer experiment description: | Using chromatin immunoprecipitations (ChIP) and ChIP sequencing (ChIP-Seq) of fetal pancreas and islet chromatin, we demonstrate that Foxa1 and Foxa2 predominantly occupy a distal Enhancer at -6.4 kb relative to the transcriptional start site in the Pdx1 gene. |
About Target gene
| Target gene : | Pdx1(IDX-1,IPF-1,Ipf1,Mody4,STF-1,pdx-1) |
| Strong evidence: | -- |
| Less strong evidence: | ChIP |
| Target gene experiment description: | We performed chromatin immunoprecipitation (ChIP) as_x0002_says with antibodies specific to either Foxa1 or Foxa2 on chromatin isolated from primary mouse islets. Both Foxa1 and Foxa2 bound to the Area IIIIII enhancer of Pdx1 in vivo. |
About TF
| TF name : | Foxa2(HNF3B,TCF3B)Foxa1(HNF3A,TCF3A) |
| TF experiment: | ChIP |
| TF experiment description: | We performed chromatin immunoprecipitation (ChIP) assays with antibodies specific to either Foxa1 or Foxa2 on chromatin isolated from primary mouse islets. Both Foxa1 and Foxa2 bound to the Area IIIIII Enhancer of Pdx1 in vivo .Notably, the binding of Foxa2 to Area IV or Area IIIIII is signifi-cantly enhanced in pancreatic islets compared with fetal pancreas. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Foxa2 | FOXA1 transcription factor network | pid | 45 |
| Foxa2 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| Foxa2 | Hedgehog signaling events mediated by Gli proteins | pid | 49 |
| Foxa2 | Regulation of gene expression in beta cells | reactome | 17 |
| Foxa2 | Maturity onset diabetes of the young | kegg | 25 |
| Foxa2 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| Foxa2 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
| Foxa2 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
| Foxa2 | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 |
| Foxa1 | AndrogenReceptor | netpath | 167 |
| Foxa1 | Direct p53 effectors | pid | 141 |
| Foxa1 | FOXA1 transcription factor network | pid | 45 |
| Foxa1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| Foxa1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene