Gene Overview
Target Gene: CHAT
NCBI Official Symbol: CHAT
Entrez ID: 1103
Ensembl ID: ENSG00000070748
Gene Full Name: choline O-acetyltransferase
Strand: +
Gene Locus: 10q11.23
External Links:

CHAT Significantly Regulated by These T(co)Fs

T(co)Fs that Activate CHAT   
T(co)Fs that Repress CHAT
The Intensity of the Gene Regulated by T(co)Fs:
CHAT-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
CHAT SPDEF shRNA Mammary_gland MCF7 0.58377 -0.77653 0.84644 0.99999 DataSet_01_107
CHAT ID1 siRNA Lung A549 0.58652 -0.76975 0.2309 0.46819 DataSet_01_117
CHAT ID1 siRNA Lung H1650 14.7997 3.88749 0.00044 0.32206 DataSet_01_118
CHAT FOXM1 siRNA Central_nervous_system U87 2.71176 1.43923 - - DataSet_01_122
CHAT IKZF2 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 0.56359 -0.82728 0.12002 0.92361 DataSet_01_137
CHAT STAT1 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 2.20172 1.13863 0.08048 0.3362 DataSet_01_154
CHAT HSF1 shRNA Skin A375 1.75281 0.80967 0.54534 0.76357 DataSet_01_155
CHAT GATA3 siRNA Peripheral_blood CD4+ T cells 1.58104 0.66088 0.00648 0.15456 DataSet_01_163
CHAT JUN siRNA Peripheral_blood CD4+ T cells 0.48491 -1.0442 0.00095 0.01484 DataSet_01_164
CHAT NFATC3 siRNA Peripheral_blood CD4+ T cells 0.61158 -0.70939 0.00972 0.09014 DataSet_01_166
CHAT NFKB1 siRNA Peripheral_blood CD4+ T cells 1.8725 0.90497 0.00174 0.11576 DataSet_01_167
CHAT TP53 siRNA Lung SAECs 0.28632 -1.80428 0.01517 0.28483 DataSet_01_175
CHAT GABPA shRNA Prostate C4-2B 1868.08 10.8673 0.23801 0.43934 DataSet_01_190
CHAT GABPA shRNA Prostate LNCaP 1075.73 10.0711 0.46117 0.7048 DataSet_01_191
CHAT CREB1 shRNA Parotid_gland H3118 MEC 5.19763 2.37785 0.47144 0.7745 DataSet_01_194
CHAT TP63 siRNA Head_and_neck SCC-1 0.62889 -0.66912 - - DataSet_01_198
CHAT TP63 siRNA Immortalized_keratinocyte HaCaT 1.55086 0.63307 - - DataSet_01_200
CHAT TP63 siRNA Head_and_neck SCC-012 0.09667 -3.37078 - - DataSet_01_201
CHAT FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 0.43391 -1.20453 - - DataSet_01_208
CHAT FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 1.53646 0.61961 - - DataSet_01_209
CHAT FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 3.32886 1.73503 - - DataSet_01_210
CHAT SNAI2 shRNA Skin Primary human keratinocytes 0.543 -0.88099 0.10208 0.21138 DataSet_01_225
CHAT SOX4 shRNA Mammary_gland MDA-MB-231 1.50443 0.58922 0.00812 0.11042 DataSet_01_260
CHAT SNAI2 siRNA Mammary_gland MCFDCIS 0.66535 -0.5878 0.04767 0.55409 DataSet_01_292
CHAT POSTN shRNA Brain GSC272 3.87625 1.95466 0.09214 0.54319 DataSet_01_293
CHAT TFAP4 siRNA Brain BE(2)-C 0.22386 -2.15935 0.39587 0.51625 DataSet_01_295
CHAT PTEN shRNA Mammary_gland SKBR3 0.29609 -1.75588 0.07384 0.59342 DataSet_01_303
CHAT MYC siRNA Colon HCT116 1.66718 0.73741 0.06597 0.10231 DataSet_01_324
CHAT GATA3 siRNA Oral_cavity OEC-M1 0.58749 -0.76737 0.20087 0.99787 DataSet_01_347
CHAT HIF1A siRNA Oral_cavity OEC-M1 2.13611 1.09498 0.0354 0.85151 DataSet_01_348
CHAT GTF2B siRNA Cervix HeLa 0.48669 -1.03893 - - DataSet_01_362
CHAT AR siRNA Prostate abl cells 0.650826 -0.619655 0.326909039750292 0.999852161656754 DataSet_03_004
CHAT AR siRNA Prostate LNCaP 0.395604 -1.33787 0.0429962581838156 1 DataSet_03_005
CHAT ATF4 siRNA Skin A375 0.663191 -0.592503 0.207246568801681 0.775512819201899 DataSet_03_018
CHAT BCL6 siRNA Lymph Pfeiffer DLBCL 1.68487 0.752641 0.396195409101458 0.795004790582378 DataSet_03_026
CHAT CEBPB siRNA Embryo hESC 3.23866 1.6954 0.23847142198322 0.621151059635942 DataSet_03_049
CHAT GATA4 siRNA Stomach AGS 4.88716 2.289 0.0116310656391064 0.496472447326172 DataSet_03_105
CHAT GATA4 siRNA Stomach KatoIII 2.14169 1.09875 0.0939378015541129 0.888685981375445 DataSet_03_106
CHAT GATA6 siRNA Stomach AGS 2.53712 1.34319 0.130151791447268 0.626285022370556 DataSet_03_108
CHAT IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 1.56188 0.643284 0.557905016349741 0.999948959532916 DataSet_03_134
CHAT KLF5 siRNA Stomach KatoIII 0.585479 -0.77231 0.470368061331999 0.818203901369141 DataSet_03_150
CHAT KLF5 siRNA Stomach YCC3 4.0504 2.01807 0.174127683447868 0.539724738791988 DataSet_03_151
CHAT MITF siRNA Skin SK-MEL-5 0.570864 -0.80878 0.000473878148525858 0.00186717599469851 DataSet_03_168
CHAT MYB siRNA Cord_Blood CD34+ progenitor cells 1.77614 0.828743 - - DataSet_03_170
CHAT MYC siRNA Colon HT29 4.31345 2.10884 - - DataSet_03_177
CHAT NR2F2 siRNA Uterus Primary eutopic stromal cells 0.433273 -1.20665 0.189408346805721 0.99947668859931 DataSet_03_202
CHAT PHB shRNA Embryo Embryonic stem cells (ESCs) 2.12654 1.08851 0.8344193725152 0.895948681666943 DataSet_03_211
CHAT SOX11 siRNA Lung_fibroblast NHLF 1.6228 0.698489 0.0694883818702835 0.433196181507032 DataSet_03_237
CHAT SOX11 siRNA Lung_fibroblast NHLF 1.73979 0.798913 0.0800876913897135 0.399232317017999 DataSet_03_238
CHAT SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.425373 -1.2332 - - DataSet_03_246
CHAT STAT3 CRISPR Embryo hESC 3.78354 1.91974 0.000204777109136982 0.0113063990664109 DataSet_03_258
CHAT STAT6 siRNA Umbilical_vein HUVEC 0.142857 -2.80735 0.0488830770989528 0.719345554770036 DataSet_03_264
CHAT TFE3 siRNA Kidney UOK257-2 3.36531 1.75074 - - DataSet_03_275
CHAT ZNF165 siRNA Mammary_gland SUM159 0.63532 -0.654444 0.463159419360551 0.999998167536832 DataSet_03_288
CHAT CNOT3 shRNA Lung A549 4.40816 2.14018 3.546277e-02 0.8830540 DataSet_03_340
CHAT SMARCA4 siRNA Colon HCT116 0.620524 -0.688442 3.179193e-01 0.6305084 DataSet_03_302
CHAT ELF3 CRISPR Bile_duct HBDEC2 0.327273 -1.61144 2.575102e-05 5.396487e-04 DataSet_03_304
CHAT BRCA1 siRNA Mammary_gland MCF7 3.4971 1.80616 1.059606e-01 0.9999931 DataSet_03_308
CHAT RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 6.80278 2.76612 2.146593e-01 4.488519e-01 DataSet_03_359
CHAT TP53 knockout Stomach SNU1 1.80274 0.850189 0.5192301203 0.9478895 DataSet_03_365
CHAT TPR shRNA Bone_marrow U2OS 1.88783 0.916726 1.286509e-02 1.624413e-01 DataSet_03_370
CHAT E2F1 siRNA Nasopharynx HK1 0.6 -0.736966 3.571404e-01 9.722824e-01 DataSet_03_373
CHAT NFKBIA shRNA Bone_marrow U2OS 0.107019 -3.22407 5.457710e-01 0.87005461 DataSet_03_389
CHAT HMGA1 shRNA Bile_duct HUCCT1 2.875 1.52356 5.200318e-01 0.716284507 DataSet_03_400
CHAT EHF shRNA Stomach MKN7 0.0203709 -5.61735 - - DataSet_03_402
CHAT CDK7 shRNA Bone_marrow D458 59 5.88264 5.531197e-05 0.02773257 DataSet_03_404
CHAT ZKSCAN3 CRISPR Colon HCT116 1.77778 0.830075 1.418507e-01 0.552607986 DataSet_03_415
CHAT NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 6 2.58496 7.624763e-02 0.216305902 DataSet_03_418
CHAT POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.5 -1 8.294273e-01 0.903787800 DataSet_03_434
CHAT FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 2.5 1.32193 4.039663e-01 0.90558273 DataSet_03_439
CHAT ARID1A shRNA Bile_duct MMNK1 1.71212 0.775783 3.036455e-01 0.545953811 DataSet_03_458
CHAT LIN28A siRNA Mammary_gland MCF7M 4.32227 2.11179 8.419690e-01 0.9827463 DataSet_03_469
CHAT LIN28A siRNA Mammary_gland MCF7M 4.32227 2.11179 8.419690e-01 0.9827463 DataSet_03_470
Regulation Region
 
T(co)Fs that significantly regulate CDK7 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of CHAT
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines