Gene Overview
Target Gene: CX3CL1
NCBI Official Symbol: CX3CL1
Entrez ID: 6376
Ensembl ID: ENSG00000006210
Gene Full Name: C-X3-C motif chemokine ligand 1
Strand: +
Gene Locus: 16q21
External Links:

CX3CL1 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate CX3CL1   
T(co)Fs that Repress CX3CL1
The Intensity of the Gene Regulated by T(co)Fs:
CX3CL1-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
CX3CL1 FOXA1 shRNA Prostate 22RV1 0.52755 -0.92261 - - DataSet_01_105
CX3CL1 ID1 siRNA Lung A549 2.1926 1.13264 0.00562 0.12108 DataSet_01_117
CX3CL1 ID1 shRNA Neuroepithelium GSC8 2.21109 1.14476 5.24473e-12 7.5218e-11 DataSet_01_134
CX3CL1 TFAP2C shRNA Mammary_gland MCF7 1.92235 0.94287 3.14891e-05 0.00012 DataSet_01_150
CX3CL1 ELK1 siRNA Peripheral_blood CD4+ T cells 0.47729 -1.06705 0.12939 0.29093 DataSet_01_162
CX3CL1 GATA3 siRNA Peripheral_blood CD4+ T cells 2.26058 1.17669 0.01972 0.2393 DataSet_01_163
CX3CL1 NFATC3 siRNA Peripheral_blood CD4+ T cells 0.50413 -0.98812 0.16614 0.43391 DataSet_01_166
CX3CL1 NFKB1 siRNA Peripheral_blood CD4+ T cells 1.64911 0.72169 0.10688 0.67337 DataSet_01_167
CX3CL1 TCF4 siRNA Autonomic_ganglia SH-SY5Y 2.07289 1.05164 0.0041 0.05586 DataSet_01_185
CX3CL1 CREB1 shRNA Parotid_gland HSY 1.56642 0.64748 0.32752 0.96523 DataSet_01_195
CX3CL1 HIC1 shRNA Mammary_gland HBL100 0.36397 -1.4581 - - DataSet_01_205
CX3CL1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 2.02717 1.01947 - - DataSet_01_209
CX3CL1 REST siRNA Prostate LNCaP 3.41842 1.77333 0.18014 0.46955 DataSet_01_211
CX3CL1 YBX1 shRNA Mammary_gland MDA 0.23489 -2.08991 1.08651e-12 6.94716e-10 DataSet_01_255
CX3CL1 YBX1 shRNA Mammary_gland MDA 0.41462 -1.27014 8.90576e-05 0.00172 DataSet_01_257
CX3CL1 SOX4 shRNA Mammary_gland MDA-MB-231 3.96941 1.98892 0.00315 0.06519 DataSet_01_260
CX3CL1 FOXO3 siRNA Pancreas PANC1 1.88925 0.91781 - - DataSet_01_267
CX3CL1 FOXO1 siRNA Umbilical_vein HUVEC 0.12785 -2.96752 0.00011 0.00683 DataSet_01_270
CX3CL1 MSX1 siRNA Tooth Dental Pulp Cells 0.39542 -1.33855 0.0347 0.0809 DataSet_01_281
CX3CL1 TFAP4 siRNA Brain BE(2)-C 0.10958 -3.18994 0.15826 0.51625 DataSet_01_295
CX3CL1 SOX7 siRNA Umbilical_vein HUVEC 0.65697 -0.6061 0.11292 0.89788 DataSet_01_299
CX3CL1 SOX17 siRNA Umbilical_vein HUVEC 0.64604 -0.63031 0.14381 0.99998 DataSet_01_300
CX3CL1 SOX9 siRNA Prostate VCaP 0.56551 -0.82239 0.17245 0.9316 DataSet_01_308
CX3CL1 SOX9 siRNA Prostate VCaP 0.56551 -0.82239 0.17245 0.9316 DataSet_01_309
CX3CL1 OVOL2 siRNA Corneal_epithelial Corneal epithelial cells 1.59679 0.67517 0.03599 0.30112 DataSet_01_313
CX3CL1 ZNF25 siRNA Bone_marrow hMSC-TERT4 1.7287 0.78969 0.04101 0.46954 DataSet_01_319
CX3CL1 RBM17 shRNA Liver HepG2 2.13135 1.09177 0.05974 0.31272 DataSet_02_100
CX3CL1 RBFOX2 shRNA Liver HepG2 1.81334 0.85865 0.11517 0.6541 DataSet_02_101
CX3CL1 U2AF2 shRNA Liver HepG2 1.60581 0.6833 0.03096 0.11245 DataSet_02_105
CX3CL1 TAF15 shRNA Liver HepG2 0.41396 -1.27243 0.00022 0.01075 DataSet_02_106
CX3CL1 SSB shRNA Liver HepG2 2.54644 1.34848 0.00022 0.0044 DataSet_02_107
CX3CL1 HNRNPUL1 shRNA Liver HepG2 1.78928 0.83938 0.00282 0.02495 DataSet_02_109
CX3CL1 RBM39 shRNA Liver HepG2 2.34704 1.23085 0.02897 0.22203 DataSet_02_111
CX3CL1 U2AF2 shRNA Liver HepG2 2.29761 1.20014 0.03787 0.12367 DataSet_02_113
CX3CL1 PCBP1 shRNA Liver HepG2 1.91535 0.9376 0.00095 0.01367 DataSet_02_115
CX3CL1 TARDBP shRNA Liver HepG2 2.00374 1.0027 0.00355 0.0235 DataSet_02_116
CX3CL1 HNRNPLL shRNA Liver HepG2 2.40889 1.26837 0.0019 0.01535 DataSet_02_125
CX3CL1 SRSF3 shRNA Liver HepG2 0.58715 -0.7682 0.02557 0.11574 DataSet_02_127
CX3CL1 SAFB2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.58824 -0.76553 0.38093 0.76519 DataSet_02_150
CX3CL1 ARID2 CRISPR Liver JHH4 0.489599 -1.03033 0.0343069438299351 1 DataSet_03_015
CX3CL1 ASCL1 siRNA Lung DMS79 0.663859 -0.591051 0.234280320312721 0.854007056101987 DataSet_03_016
CX3CL1 CEBPB siRNA Embryo hESC 0.567508 -0.817289 0.0800197535094067 0.432587565904469 DataSet_03_049
CX3CL1 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 3.79442 1.92388 - - DataSet_03_096
CX3CL1 GATA6 siRNA Stomach AGS 2.11245 1.07892 0.0029301784093977 0.179753579194072 DataSet_03_108
CX3CL1 HNF4a siRNA Liver HepG2 0.507557 -0.978358 0.00690075906263166 0.447412986530804 DataSet_03_126
CX3CL1 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 1.81513 0.860071 0.0472178385561494 0.814761635401907 DataSet_03_134
CX3CL1 KLF5 siRNA Stomach AGS 1.63477 0.709088 0.043970835507847 0.47824632994597 DataSet_03_149
CX3CL1 KLF5 siRNA Stomach KatoIII 1.55393 0.635924 0.208049282832121 0.657419578011411 DataSet_03_150
CX3CL1 KLF5 siRNA Stomach YCC3 2.34338 1.22859 0.0231650414986814 0.241637270546216 DataSet_03_151
CX3CL1 MEF2D siRNA Liver HuH7 0.646875 -0.628442 - - DataSet_03_163
CX3CL1 MITF siRNA Skin MZ7 0.59586 -0.746955 3.27702889906202e-05 0.000337368666540231 DataSet_03_165
CX3CL1 MITF siRNA Skin SK-MEL-5 0.6228 -0.68316 0.00318058931465849 0.00849480537433963 DataSet_03_168
CX3CL1 MTA2 siRNA Stomach SGC-7901 1.82245 0.865877 - - DataSet_03_169
CX3CL1 NR4A3 siRNA Pancreas 1.1B4 1.62726 0.702442 6.66564181970768e-05 0.000597433695535069 DataSet_03_203
CX3CL1 PRRX1 CRISPR Neuroblastoma 691-MES 0.558059 -0.84151 0.504282986901369 0.931466551489076 DataSet_03_217
CX3CL1 SP1 siRNA Ovary OVSAYO 1.65746 0.728978 0.0147113344066429 0.157898152686705 DataSet_03_251
CX3CL1 STAT1 knockout Liver Huh-7.5 1.56278 0.644117 0.000183761022651211 0.0140334513052734 DataSet_03_257
CX3CL1 STAT3 CRISPR Embryo hESC 1.5441 0.626766 0.162146289499078 0.229106935682186 DataSet_03_258
CX3CL1 STAT6 siRNA Umbilical_vein HUVEC 1.61111 0.688056 0.294119783621368 0.872129797935194 DataSet_03_264
CX3CL1 TP53 knockout Haematopoietic_and_lymphoid_tissue MOLP8 1.60818 0.685432 0.0339222182063054 0.674030075796594 DataSet_03_280
CX3CL1 NFX1 CRISPR Liver HepG2 2.10833 1.0761 0.000433632351884482 0.0114553725816699 DataSet_04_032
CX3CL1 CCAR1 shRNA Liver HepG2 1.50281 0.587662 0.00227403619499505 0.0231847360577235 DataSet_04_054
CX3CL1 CNOT7 shRNA Liver HepG2 2.90771 1.53988 1.68144046817578e-05 0.00158756302085018 DataSet_04_051
CX3CL1 DDX1 shRNA Liver HepG2 1.81768 0.862097 0.000263472035336628 0.0429589673467077 DataSet_04_057
CX3CL1 PRPF6 shRNA Liver HepG2 1.50286 0.587706 0.0244370774348797 0.116140205203543 DataSet_04_056
CX3CL1 UBE2L3 shRNA Liver HepG2 1.57432 0.654728 0.00102141277318147 0.0116162898552558 DataSet_04_055
CX3CL1 CITED2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 10.1905 3.34915 0.241200944205697 0.506916816884776 DataSet_02_38
CX3CL1 ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 4.38095 2.13124 0.220549075165013 0.382033663453909 DataSet_02_34
CX3CL1 HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.569231 -0.812914 0.562500006881752 0.841083274386725 DataSet_02_75
CX3CL1 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 9.61905 3.26589 0.0076665577507584 0.411225918374791 DataSet_02_45
CX3CL1 LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.90476 1.53842 0.285632718409239 0.458891808240218 DataSet_02_35
CX3CL1 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 14.7619 3.88381 0.151251452681422 0.452714410365694 DataSet_02_32
CX3CL1 SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.0952381 -3.39232 0.336199313501191 0.497424886337709 DataSet_02_47
CX3CL1 TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.047619 -4.39232 0.317310066099574 0.472025515510698 DataSet_02_33
CX3CL1 TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 3.04762 1.60768 0.2675128003492 0.434553657479577 DataSet_02_53
CX3CL1 SNAI2 shRNA Pancreas KLM1 0.202096 -2.30689 8.631152e-02 0.38648383 DataSet_03_307
CX3CL1 EZH2 knockdown Colon HCT116 1.80662 0.85329 0.165581949 0.8567432 DataSet_03_334
CX3CL1 ARID3B CRISPR Colon HCT15 0.591416 -0.757755 - - DataSet_03_335
CX3CL1 TET1 CRISPR Mammary_gland MDA-MB-231 0.0979008 -3.35254 1.395140e-07 4.101967e-05 DataSet_03_347
CX3CL1 SKI CRISPR Blood HL60 0.636364 -0.652077 1.451844e-01 0.531191129 DataSet_03_351
CX3CL1 ESR1 siRNA Mammary_gland MCF7 3.36796 1.75188 1.107527e-03 0.0199773745 DataSet_03_352
CX3CL1 ETV5 knockdown Colon HT29 0.135714 -2.88136 2.752118e-04 0.031283238 DataSet_03_353
CX3CL1 TET1 CRISPR Mammary_gland Hs578T 3.24987 1.70038 2.718183e-01 4.653096e-01 DataSet_03_355
CX3CL1 PTPN14 CRISPR Brain U5-NPC 0.328386 -1.60654 1.164605e-02 0.23211028 DataSet_03_357
CX3CL1 ZNF148 shRNA Mammary_gland MDA-MB-231 3.07936 1.62263 9.921741e-03 0.071182551 DataSet_03_366
CX3CL1 USP22 shRNA Liver PLC_PRF_5 cells 0.649123 -0.623437 2.859821e-01 0.50893905 DataSet_03_368
CX3CL1 TPR shRNA Bone_marrow U2OS 2.4326 1.2825 1.661936e-04 1.141770e-02 DataSet_03_370
CX3CL1 ZFP36L1 siRNA Urinary_bladder J82 4.5 2.16992 - - DataSet_03_371
CX3CL1 E2F1 siRNA Nasopharynx HK1 0.5 -1 5.409393e-01 1.000000e+00 DataSet_03_373
CX3CL1 GLI1 siRNA Skeletal_muscle RMS13 2.88695 1.52954 1.747382e-03 0.028077614 DataSet_03_375
CX3CL1 ZNF213 siRNA Mammary_gland MCF7 123.035 6.94292 3.260514e-01 6.592819e-01 DataSet_03_376
CX3CL1 EZH2 CRISPR Ovary SKOV3 0.5 -1 2.192102e-01 0.4472552208 DataSet_03_378
CX3CL1 DDX5 shRNA Stomach HGC-27 0.636364 -0.652077 - - DataSet_03_379
CX3CL1 NFKB2 siRNA Bone_marrow U2OS 0.477679 -1.06589 1.780546e-02 0.18209894 DataSet_03_381
CX3CL1 TCF19 CRISPR Oral_squamous CAL27 1.9915 0.993858 4.508982e-03 0.0457956183 DataSet_03_383
CX3CL1 NFKBIA shRNA Bone_marrow U2OS 0.651758 -0.617591 5.785875e-01 0.87005461 DataSet_03_389
CX3CL1 KDM5A CRISPR Lung GLC16 2.19857 1.13656 6.436302e-01 0.776314694 DataSet_03_392
CX3CL1 ASXL1 CRISPR Embryo iPSC 1.70665 0.771163 0.0629778879 0.8048302 DataSet_03_394
CX3CL1 IKZF2 CRISPR Lymph CAR T Cell 0.565593 -0.822164 6.199588e-01 0.900835677 DataSet_03_397
CX3CL1 EHF shRNA Stomach MKN7 0.00478975 -7.70583 - - DataSet_03_402
CX3CL1 CDK7 shRNA Bone_marrow D458 5.10596 2.35218 4.448043e-03 0.12642012 DataSet_03_404
CX3CL1 SATB2 CRISPR Colon Colon organoid 1.57487 0.655234 1.605142e-01 0.95735254 DataSet_03_406
CX3CL1 CHD1 shRNA Prostate LNCaP 0.177914 -2.49075 1.000473e-04 1.456613e-02 DataSet_03_407
CX3CL1 MAP3K7 shRNA Prostate LNCaP 0.288344 -1.79414 1.860974e-03 2.936783e-02 DataSet_03_408
CX3CL1 STRAP knockout Nerve SK-N-AS 0.339717 -1.5576 - - DataSet_03_409
CX3CL1 SIRT1 siRNA Pancreas PANC1 0.43614 -1.19714 1.188611e-04 0.010798164 DataSet_03_410
CX3CL1 E2F6 shRNA Liver HuH7 0.402481 -1.31301 - - DataSet_03_412
CX3CL1 ZKSCAN3 CRISPR Colon HCT116 0.333333 -1.58496 6.764258e-01 0.873497177 DataSet_03_415
CX3CL1 FOXK2 shRNA Ovary OVCAR-5 0.0398773 -4.64829 2.148435e-03 0.08266460 DataSet_03_419
CX3CL1 IKZF2 shRNA Lymph Hut78 1.86502 0.899194 6.746745e-01 0.89738299 DataSet_03_429
CX3CL1 USP7 shRNA Skin xenograft cells 0.377209 -1.40656 0.26995655 0.4348960 DataSet_03_431
CX3CL1 NFE2L1 knockout Lung A549 14.8029 3.88781 3.018935e-02 4.368723e-01 DataSet_03_433
CX3CL1 SUFU shRNA Mammary_gland HCC1954 cells 0.600614 -0.735489 0.3749822347 0.6919033 DataSet_03_437
CX3CL1 CIC knockout Brain Immortalized Astrocyte Cells 0.353448 -1.50043 3.340806e-01 7.523309e-01 DataSet_03_438
CX3CL1 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 3.11111 1.63743 1.944331e-01 0.90558273 DataSet_03_439
CX3CL1 HMG20A siRNA Mammary_gland MDA-MB-231 0.621749 -0.685595 0.0930261921 0.3168956 DataSet_03_442
CX3CL1 CBX2 siRNA Mammary_gland MDA-MB-231 1.55635 0.638165 1.252285e-02 5.500748e-02 DataSet_03_450
CX3CL1 CBX2 siRNA Mammary_gland MCF7 0.373219 -1.4219 4.439802e-01 0.6130423453 DataSet_03_451
CX3CL1 OGT siRNA Embryo BeWo cells 12 3.58496 9.968903e-02 0.60583253 DataSet_03_453
CX3CL1 ZFP36L1 CRISPR Lung NCI-H1876 0.560325 -0.835664 6.122464e-01 0.992381486 DataSet_03_454
CX3CL1 SREBF2 siRNA Umbilical_vein HUVEC 2.12549 1.0878 8.531401e-01 9.668312e-01 DataSet_03_457
CX3CL1 ARID1A shRNA Bile_duct MMNK1 0.437458 -1.19279 3.731475e-02 0.207868204 DataSet_03_458
CX3CL1 SOX9 knockout Liver HuH7 0.633101 -0.659493 1.594672e-01 3.147159e-01 DataSet_03_463
CX3CL1 PARP1 knockout Embryo_kidney HEK293a 0.414184 -1.27165 4.201795e-02 1.024230e-01 DataSet_03_464
CX3CL1 SMARCA1 Cas13 Embryo_kidney HEK293T 3.5 1.80735 - - DataSet_03_466
CX3CL1 WHSC1 siRNA Prostate PC3 2.83333 1.5025 3.411250e-01 0.56300525 DataSet_03_471
CX3CL1 EZH2 siRNA Umbilical_vein HUVEC 1.62191 0.697692 1.104886e-03 0.058035038 DataSet_03_473
CX3CL1 CREBBP CRISPR Lymph U2932 0.444444 -1.16992 2.124825e-01 1.0000000 DataSet_03_474
CX3CL1 HMGB2 knockdown Umbilical_vein HUVEC 0.641593 -0.64027 1.458653e-02 0.09295154 DataSet_03_476
Regulation Region
 
T(co)Fs that significantly regulate OGT by the evidences of both expression and ChIP-seq/motif
Expression Atlas of CX3CL1
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines