Gene Overview
Target Gene: FAM135A
NCBI Official Symbol: FAM135A
Entrez ID: 57579
Ensembl ID: ENSG00000082269
Gene Full Name: family with sequence similarity 135 member A
Strand: +
Gene Locus: 6q13
External Links:

FAM135A Significantly Regulated by These T(co)Fs

T(co)Fs that Activate FAM135A   
T(co)Fs that Repress FAM135A
The Intensity of the Gene Regulated by T(co)Fs:
FAM135A-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
FAM135A SPDEF shRNA Mammary_gland MCF7 3.28456 1.7157 0.43417 0.99999 DataSet_01_107
FAM135A ID1 siRNA Lung A549 1.62631 0.70161 0.0165 0.16351 DataSet_01_117
FAM135A ZIC2 siRNA Pancreas PANC1 1.62593 0.70127 - - DataSet_01_121
FAM135A FOXM1 siRNA Central_nervous_system U87 0.27425 -1.86644 - - DataSet_01_122
FAM135A IKZF1 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 1.50888 0.59348 0.26849 0.99993 DataSet_01_138
FAM135A POLR3A siRNA Mammary_gland MCF7 0.36174 -1.46698 - - DataSet_01_139
FAM135A GATA3 siRNA Peripheral_blood CD4+ T cells 1.59343 0.67213 0.28507 0.63056 DataSet_01_163
FAM135A JUN siRNA Peripheral_blood CD4+ T cells 1.62516 0.70058 0.03808 0.16496 DataSet_01_164
FAM135A GABPA shRNA Prostate C4-2B 1564.6 10.6116 0.2377 0.43934 DataSet_01_190
FAM135A GABPA shRNA Prostate LNCaP 1178.23 10.2024 0.46164 0.7048 DataSet_01_191
FAM135A TP63 siRNA Immortalized_keratinocyte HaCaT RG 1.775 0.82782 - - DataSet_01_196
FAM135A TP63 siRNA Immortalized_keratinocyte HaCaT RG 0.54751 -0.86904 - - DataSet_01_197
FAM135A TP63 siRNA Head_and_neck SCC-1 2.24242 1.16506 - - DataSet_01_198
FAM135A ERG siRNA Prostate VCaP 2.13696 1.09556 1.66072e-06 3e-04 DataSet_01_216
FAM135A SNAI2 shRNA Skin Primary human keratinocytes 2.13867 1.09671 0.00031 0.01053 DataSet_01_225
FAM135A IRX1 shRNA Bone_marrow 143B 2.05391 1.03837 0.03113 0.18395 DataSet_01_227
FAM135A STAT5 shRNA Haematopoietic_and_lymphoid_tissue K562 2.61825 1.3886 3.058e-06 0.00027 DataSet_01_239
FAM135A FOXO3 siRNA Pancreas PANC1 0.5932 -0.75342 - - DataSet_01_267
FAM135A SALL4 shRNA Lung H661 2.20695 1.14205 0.01601 0.15364 DataSet_01_277
FAM135A TFAP4 siRNA Brain BE(2)-C 0.21436 -2.22188 0.3703 0.51625 DataSet_01_295
FAM135A SOX9 siRNA Prostate VCaP 1.52701 0.61071 0.24692 0.93226 DataSet_01_308
FAM135A SOX9 siRNA Prostate VCaP 1.52701 0.61071 0.24692 0.93226 DataSet_01_309
FAM135A ARNT siRNA Upper_aerodigestive_tract HSC3 1.99722 0.99799 - - DataSet_01_315
FAM135A ELK3 shRNA Mammary_gland MDA-MB-231 1.51544 0.59974 0.00193 0.00578 DataSet_01_318
FAM135A HOXC6 siRNA Prostate LNCaP 0.10816 -3.20877 0.00088 0.9106 DataSet_01_333
FAM135A CDX2 siRNA Colon COLO320 0.51808 -0.94874 - - DataSet_01_357
FAM135A SAFB2 shRNA Liver HepG2 0.36539 -1.45248 0.00025 0.02192 DataSet_02_102
FAM135A FIP1L1 shRNA Liver HepG2 2.18187 1.12556 0.00547 0.03058 DataSet_02_103
FAM135A U2AF2 shRNA Liver HepG2 1.56382 0.64508 0.33315 0.48222 DataSet_02_105
FAM135A TAF15 shRNA Liver HepG2 1.50127 0.58619 0.01025 0.03062 DataSet_02_106
FAM135A SSB shRNA Liver HepG2 0.64722 -0.62768 0.00149 0.00897 DataSet_02_107
FAM135A ZNF622 shRNA Liver HepG2 2.37874 1.25019 0.00204 0.01133 DataSet_02_108
FAM135A HNRNPUL1 shRNA Liver HepG2 0.53938 -0.89063 0.00792 0.03656 DataSet_02_109
FAM135A RBM39 shRNA Liver HepG2 0.57347 -0.8022 0.01541 0.21151 DataSet_02_111
FAM135A XRCC5 shRNA Liver HepG2 2.06128 1.04354 0.00156 0.12055 DataSet_02_114
FAM135A PCBP1 shRNA Liver HepG2 1.84537 0.88391 0.00227 0.01651 DataSet_02_115
FAM135A TARDBP shRNA Liver HepG2 0.52839 -0.92031 0.00969 0.03672 DataSet_02_116
FAM135A SUB1 shRNA Liver HepG2 1.8732 0.90551 0.00398 0.12645 DataSet_02_117
FAM135A PTBP1 shRNA Liver HepG2 2.98131 1.57595 0.00143 0.00788 DataSet_02_120
FAM135A EWSR1 shRNA Liver HepG2 1.53093 0.61441 0.04044 0.11722 DataSet_02_122
FAM135A SRSF3 shRNA Liver HepG2 1.74238 0.80106 0.02165 0.10728 DataSet_02_127
FAM135A RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 0.52929 -0.91787 0.00192 0.02156 DataSet_02_143
FAM135A PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.54248 0.62525 0.01048 0.19832 DataSet_02_144
FAM135A NONO shRNA Haematopoietic_and_lymphoid_tissue K562 0.61064 -0.7116 0.01829 0.19507 DataSet_02_149
FAM135A ZFX siRNA Mammary_gland MCF7 0.65517 -0.61005 0.12897 0.33952 DataSet_02_206
FAM135A AR siRNA Prostate LNCaP 1.91943 0.940679 0.18749705105174 1 DataSet_03_005
FAM135A CEBPB siRNA Embryo hESC 0.481354 -1.05483 0.325243512682183 0.692698356199412 DataSet_03_049
FAM135A FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 2.47418 1.30695 - - DataSet_03_096
FAM135A HINFP siRNA Bone_marrow hTERT-RPE1 1.54048 0.623377 0.000482404173809211 0.0549408234054529 DataSet_03_122
FAM135A HINFP siRNA Bone_marrow U2OS 1.52793 0.611578 0.000606518391978364 0.0215338584552804 DataSet_03_123
FAM135A HNF4a siRNA Liver HepG2 1.59405 0.672698 0.0635532433121501 0.664339522212349 DataSet_03_126
FAM135A MYB siRNA Prostate VCaP 0.531141 -0.912833 0.00015337927320474 0.0161841662527773 DataSet_03_174
FAM135A MYC siRNA Colon HT29 1.57914 0.659138 - - DataSet_03_177
FAM135A NFKB1 siRNA Central_nervous_system U251 0.642415 -0.638422 0.0782470378111573 0.182063455602965 DataSet_03_197
FAM135A RELB siRNA Immortalized_keratinocyte HaCaT 3.04044 1.60428 5.59870920354718e-05 0.000768756094687061 DataSet_03_227
FAM135A SOX11 siRNA Lung_fibroblast NHLF 1.73691 0.79652 0.00615231586512229 0.304507242190339 DataSet_03_237
FAM135A SOX11 siRNA Lung_fibroblast NHLF 1.92752 0.946742 0.00672463577391239 0.187773672980584 DataSet_03_238
FAM135A SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 1.51667 0.600904 - - DataSet_03_246
FAM135A STAT6 siRNA Umbilical_vein HUVEC 1.6125 0.689299 0.281788088544413 0.870695740656481 DataSet_03_264
FAM135A TET1 siRNA Embryo NCCIT 1.55584 0.637695 0.000119932678710436 0.0038356867764905 DataSet_03_269
FAM135A TET2 siRNA Embryo NCCIT 1.63298 0.70751 8.2635168297885e-05 0.00223431307136752 DataSet_03_270
FAM135A TET3 siRNA Embryo NCCIT 1.59201 0.67085 0.000153738916023964 0.00567374071243322 DataSet_03_273
FAM135A TFAP2C siRNA Mammary_gland MCF7 2.24816 1.16874 0.0393812522647074 0.361356363471288 DataSet_03_274
FAM135A TP63 siRNA Foreskin Neonatal foreskin keratinocytes 1.72405 0.785803 0.117670238400268 0.74068467747383 DataSet_03_282
FAM135A NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 4.42945 2.14713 0.111956934840955 0.230229026221367 DataSet_04_014
FAM135A CCAR1 shRNA Liver HepG2 0.620791 -0.687821 0.0083740981279288 0.0438052212446145 DataSet_04_054
FAM135A YBX3 shRNA Liver HepG2 0.639155 -0.645761 0.00102152941190869 0.0397152339584818 DataSet_02_98
FAM135A NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.04151 1.02964 0.0622663258011236 0.389492262829695 DataSet_02_32
FAM135A TBL1XR1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.51549 0.599784 0.00276934073426304 0.0276164696347475 DataSet_02_43
FAM135A TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.76208 0.817281 0.00731275629821505 0.0279155902048073 DataSet_02_33
FAM135A TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.51053 0.595058 0.0722313030744143 0.178887876155941 DataSet_02_53
FAM135A CNOT7 shRNA Haematopoietic_and_lymphoid_tissue K562 1.69023 0.757221 0.000997564146807275 0.0429178521696285 DataSet_04_061
FAM135A TET1 CRISPR Mammary_gland MDA-MB-231 2.28463 1.19196 2.063459e-02 9.857895e-02 DataSet_03_347
FAM135A ETV5 knockdown Colon HT29 0.455882 -1.13327 2.210535e-03 0.058943196 DataSet_03_353
FAM135A PARP1 siRNA Prostate LNCaP 0.623067 -0.68254 1.174206e-02 0.140288235 DataSet_03_354
FAM135A TP53 CRISPR Brain U5-NPC 1.83034 0.872113 1.313869e-01 2.666310e-01 DataSet_03_358
FAM135A RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 1.54029 0.6232 7.260504e-04 4.571496e-02 DataSet_03_359
FAM135A ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 1.65984 0.731043 2.857186e-05 2.404798e-04 DataSet_03_362
FAM135A MYC siRNA Peripheral_blood T lymphocyte 1.5327 0.616076 3.149182e-03 0.038899035 DataSet_03_363
FAM135A EP300 shRNA Mammary_gland MCF10AT 0.424528 -1.23607 3.556669e-03 0.040614302 DataSet_03_364
FAM135A USP22 shRNA Liver PLC_PRF_5 cells 0.316667 -1.65896 6.999906e-02 0.25168654 DataSet_03_368
FAM135A ZFP36L1 siRNA Urinary_bladder J82 2.83664 1.50418 - - DataSet_03_371
FAM135A ZNF213 siRNA Mammary_gland MCF7 2.97636 1.57355 1.438338e-01 6.031019e-01 DataSet_03_376
FAM135A NFKB2 siRNA Bone_marrow U2OS 1.67094 0.740657 6.730828e-02 0.32883079 DataSet_03_381
FAM135A TCF19 CRISPR Oral_squamous CAL27 0.603225 -0.729232 7.590423e-02 0.2794806423 DataSet_03_383
FAM135A TRIM8 siRNA Mammary_gland MCF7 1.8512 0.888463 1.119368e-03 0.0136163265 DataSet_03_388
FAM135A NFKBIA shRNA Bone_marrow U2OS 0.569245 -0.812878 6.141543e-01 0.87005461 DataSet_03_389
FAM135A YY1 knockdown Liver HepG2 2.95029 1.56086 2.383869e-12 2.724078e-10 DataSet_03_390
FAM135A ILF2 siRNA Stomach SGC-7901 2.90541 1.53874 0.0027069598 0.02546153 DataSet_03_393
FAM135A ASXL1 CRISPR Embryo iPSC 0.604348 -0.726549 0.0955750068 0.8082676 DataSet_03_394
FAM135A RELA CRISPR Brain T30 0.330888 -1.59559 0.3042013594 0.8400824 DataSet_03_399
FAM135A CHD1 shRNA Prostate LNCaP 0.582498 -0.779674 1.968420e-02 3.172909e-01 DataSet_03_407
FAM135A USP22 shRNA Liver HuH7 3.52193 1.81637 - - DataSet_03_411
FAM135A E2F6 shRNA Liver HuH7 0.423458 -1.23971 - - DataSet_03_412
FAM135A E2F1 siRNA Prostate LNCaP 0.591544 -0.757443 1.635854e-01 0.7117863623 DataSet_03_413
FAM135A FOXK2 shRNA Ovary OVCAR-5 2.24648 1.16767 1.310347e-01 0.33225174 DataSet_03_419
FAM135A MAEL CRISPR Liver Alexander cells 0.508804 -0.974817 - - DataSet_03_423
FAM135A USP7 shRNA Skin xenograft cells 0.421564 -1.24617 0.27042990 0.4348960 DataSet_03_431
FAM135A EP300 knockout Pancreas HPAF-II orthotopic cells 0.511986 -0.965823 8.791777e-04 7.241648e-03 DataSet_03_436
FAM135A SETDB1 shRNA Colon HCT116 0.589139 -0.76332 - - DataSet_03_440
FAM135A DAXX shRNA Mammary_gland MDA-MB-231 0.114794 -3.12288 2.323804e-02 0.16823814 DataSet_03_441
FAM135A PURA siRNA Cervix HeLa 1.94779 0.961839 3.852617e-03 0.065460517 DataSet_03_444
FAM135A CAMTA1 knockout Embryo_kidney HEK293T 1.51971 0.603799 5.075527e-02 0.18683183 DataSet_03_448
FAM135A CBX2 siRNA Mammary_gland MDA-MB-231 0.425454 -1.23292 5.900297e-03 3.188122e-02 DataSet_03_450
FAM135A CBX2 siRNA Mammary_gland MCF7 0.513599 -0.961285 2.402452e-02 0.0606559190 DataSet_03_451
FAM135A SMARCA2 shRNA Lung HCC2302 2.46746 1.30303 9.131705e-06 1.966656e-05 DataSet_03_455
FAM135A ARID1A shRNA Bile_duct MMNK1 1.91825 0.939792 2.706728e-03 0.048433968 DataSet_03_458
FAM135A IRF2 shRNA Cord_Blood CD34+ cells 1.57643 0.656659 - - DataSet_03_460
FAM135A TXNIP shRNA Cord_Blood CD34+ cells 1.69591 0.762057 - - DataSet_03_461
FAM135A TXNIP shRNA Cord_blood ST3 1.50249 0.587353 1.715563e-01 0.4611873423 DataSet_03_462
FAM135A SOX9 knockout Liver HuH7 0.36918 -1.4376 6.234009e-05 1.646110e-03 DataSet_03_463
FAM135A PARP1 knockout Embryo_kidney HEK293a 1.62945 0.704384 7.602694e-05 5.267581e-04 DataSet_03_464
FAM135A SMARCA1 Cas13 Embryo_kidney HEK293T 0.556334 -0.845976 - - DataSet_03_466
FAM135A SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 1.64997 0.722444 - - DataSet_03_467
FAM135A EZH2 siRNA Prostate LNCaP 0.623932 -0.68054 2.086874e-01 1.0000000 DataSet_03_475
Regulation Region
 
T(co)Fs that significantly regulate HOXC6 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of FAM135A
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines