Gene Overview
Target Gene: GPC3
NCBI Official Symbol: GPC3
Entrez ID: 2719
Ensembl ID: ENSG00000147257
Gene Full Name: glypican 3
Strand: -
Gene Locus: Xq26.2
External Links:

GPC3 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate GPC3   
T(co)Fs that Repress GPC3
The Intensity of the Gene Regulated by T(co)Fs:
GPC3-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
GPC3 HNF1B shRNA Ovary RMG2 0.54725 -0.86972 6.57639e-12 6.4577e-10 DataSet_01_103
GPC3 FOXM1 siRNA Central_nervous_system U87 0.29425 -1.76488 - - DataSet_01_122
GPC3 ZNF43 siRNA Gastrointestinal_tissue GIST-T1 1.84258 0.88173 0.00064 0.01672 DataSet_01_125
GPC3 ZNF254 siRNA Gastrointestinal_tissue GIST-T1 1.595 0.67356 0.00371 0.02988 DataSet_01_127
GPC3 LIN28B siRNA Embryo_kidney HEK293 1.53519 0.61842 0.00382 0.03471 DataSet_01_153
GPC3 ELK1 siRNA Peripheral_blood CD4+ T cells 2.74155 1.45499 3.7366e-05 0.00146 DataSet_01_162
GPC3 GATA3 siRNA Peripheral_blood CD4+ T cells 2.36084 1.2393 0.00026 0.03393 DataSet_01_163
GPC3 JUN siRNA Peripheral_blood CD4+ T cells 2.02985 1.02138 0.00042 0.0087 DataSet_01_164
GPC3 MAF siRNA Peripheral_blood CD4+ T cells 1.50349 0.58832 0.01283 0.12234 DataSet_01_165
GPC3 NFATC3 siRNA Peripheral_blood CD4+ T cells 2.13464 1.09399 0.00067 0.01876 DataSet_01_166
GPC3 NFKB1 siRNA Peripheral_blood CD4+ T cells 1.96003 0.97088 0.00178 0.11676 DataSet_01_167
GPC3 ESRRG siRNA Placenta_tissue Trophoblast cells 0.51016 -0.97098 0.00938 0.12421 DataSet_01_173
GPC3 TP53 siRNA Lung SAECs 1.82661 0.86917 0.06918 0.44316 DataSet_01_175
GPC3 CREB1 shRNA Parotid_gland H3118 MEC 2.00131 1.00094 0.25392 0.6196 DataSet_01_194
GPC3 CREB1 shRNA Parotid_gland HSY 1.58879 0.66793 0.52019 0.98114 DataSet_01_195
GPC3 TP63 siRNA Head_and_neck SCC-1 0.62794 -0.67131 - - DataSet_01_199
GPC3 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 1.92732 0.9466 - - DataSet_01_208
GPC3 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 0.61417 -0.70329 - - DataSet_01_209
GPC3 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 1.91029 0.93379 - - DataSet_01_210
GPC3 LIN28A siRNA Embryo H9 2.42012 1.27508 0.0024 0.0208 DataSet_01_215
GPC3 KLF2 shRNA Bone_marrow RPMI8226 0.47356 -1.07839 0.09155 0.69978 DataSet_01_226
GPC3 IRX1 shRNA Bone_marrow 143B 0.26894 -1.89462 0.32303 0.57789 DataSet_01_227
GPC3 FOXA1 siRNA Prostate LNCaP 0.66119 -0.59685 0.03843 0.28948 DataSet_01_233
GPC3 FOXP1 siRNA Prostate LNCaP 0.6566 -0.60691 0.01867 0.30488 DataSet_01_234
GPC3 AR shRNA Prostate CWR22Pc 0.31466 -1.66813 0.00194 0.02244 DataSet_01_278
GPC3 STAT5 shRNA Prostate CWR22Pc 0.47869 -1.06285 0.00018 0.00804 DataSet_01_279
GPC3 ESRRA shRNA Embryo_kidney 293T 0.5798 -0.78636 0.01 0.56555 DataSet_01_280
GPC3 AHR siRNA Haematopoietic_and_lymphoid_tissue THP-1 1.53696 0.62008 1.22329e-05 4e-04 DataSet_01_283
GPC3 TFAP4 siRNA Brain BE(2)-C 0.18863 -2.4064 0.35488 0.51625 DataSet_01_295
GPC3 SOX17 siRNA Umbilical_vein HUVEC 1.59849 0.67671 0.12578 0.99998 DataSet_01_300
GPC3 PTEN shRNA Skin A431 1.81067 0.85652 0.32643 0.5266 DataSet_01_301
GPC3 PTEN shRNA Lung HCC827 4.19271 2.06788 0.15989 0.6458 DataSet_01_302
GPC3 PTEN shRNA Mammary_gland SKBR3 0.4432 -1.17397 0.60808 0.86677 DataSet_01_303
GPC3 SOX9 siRNA Prostate VCaP 0.65737 -0.60522 0.03847 0.9316 DataSet_01_308
GPC3 SOX9 siRNA Prostate VCaP 0.65737 -0.60522 0.03847 0.9316 DataSet_01_309
GPC3 OVOL2 siRNA Corneal_epithelial Corneal epithelial cells 1.76793 0.82206 0.14437 0.37364 DataSet_01_313
GPC3 RUNX1 shRNA Embryo H9 1.7602 0.81574 0.08021 0.25389 DataSet_01_314
GPC3 ARNT siRNA Upper_aerodigestive_tract HSC3 1.9617 0.9721 - - DataSet_01_315
GPC3 ELK3 shRNA Mammary_gland MDA-MB-231 16.5769 4.0511 1.69484e-07 1.37985e-05 DataSet_01_318
GPC3 TOX shRNA Haematopoietic_and_lymphoid_tissue CCRF-CEM 2.23063 1.15745 0.00027 0.51427 DataSet_01_331
GPC3 RUNX1 shRNA Haematopoietic_and_lymphoid_tissue MV4-11 1.51798 0.60216 0.01311 0.99997 DataSet_01_344
GPC3 ZNF24 siRNA Embryo_kidney HEK293 1.55229 0.6344 - - DataSet_01_353
GPC3 CDX2 siRNA Colon COLO320 0.40644 -1.29887 - - DataSet_01_357
GPC3 PAX3 shRNA Soft_tissue Rh30 0.45024 -1.15123 - - DataSet_01_359
GPC3 RBM17 shRNA Liver HepG2 0.55791 -0.84189 0.01397 0.26816 DataSet_02_100
GPC3 FIP1L1 shRNA Liver HepG2 0.64674 -0.62873 0.0037 0.02547 DataSet_02_103
GPC3 BCLAF1 shRNA Liver HepG2 1.57605 0.65631 0.00305 0.03012 DataSet_02_112
GPC3 U2AF2 shRNA Liver HepG2 0.58446 -0.77481 0.63612 0.74336 DataSet_02_113
GPC3 TARDBP shRNA Liver HepG2 2.12903 1.09019 0.00188 0.01878 DataSet_02_116
GPC3 HNRNPLL shRNA Liver HepG2 1.74209 0.80082 0.00295 0.01826 DataSet_02_125
GPC3 PSIP1 shRNA Haematopoietic_and_lymphoid_tissue K562 4 2 0.03059 0.11442 DataSet_02_158
GPC3 FLI1 siRNA Haematopoietic_and_lymphoid_tissue THP-1 0.58674 -0.769206 3.36573928293079e-05 0.0227343707243391 DataSet_03_078
GPC3 FOXF2 siRNA Mammary_gland MDA-MB-231 1.59101 0.669947 - - DataSet_03_087
GPC3 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 0.296928 -1.75182 0.0337664879298945 0.753082274154105 DataSet_03_134
GPC3 KLF5 siRNA Stomach YCC3 1.82696 0.869443 0.130828454813731 0.484537401914033 DataSet_03_151
GPC3 MEF2D shRNA Liver HuH7 1.70485 0.769642 - - DataSet_03_162
GPC3 MYB siRNA Cord_Blood CD34+ progenitor cells 0.139847 -2.83808 - - DataSet_03_170
GPC3 MYC siRNA Colon HT29 0.11855 -3.07643 - - DataSet_03_177
GPC3 MYC siRNA Central_nervous_system DAOY M2.1 0.61735 -0.695839 3.69080766781731e-06 2.22568755351111e-05 DataSet_03_178
GPC3 PHB shRNA Embryo Embryonic stem cells (ESCs) 0.302665 -1.72421 2.2892753900284e-05 0.000551437803905061 DataSet_03_211
GPC3 PRRX1 CRISPR Neuroblastoma 691-MES 0.546204 -0.872488 0.0690131851446508 0.89189998148014 DataSet_03_217
GPC3 SOX2 CRISPR Seminoma-like TCam-2 5.71264 2.51416 0.113859157842034 0.999580851453413 DataSet_03_244
GPC3 SOX2 siRNA Mammary_gland GSC-11 1.51104 0.595538 0.00301079281893585 0.0392807464589276 DataSet_03_245
GPC3 SP1 siRNA Mammary_gland MDA-MB-231 0.525756 -0.927534 0.167089502570966 0.413972819854456 DataSet_03_250
GPC3 SP1 siRNA Ovary OVSAYO 5.20633 2.38027 0.000248622560867229 0.0593489715581834 DataSet_03_251
GPC3 STAT3 CRISPR Embryo hESC 0.406159 -1.29988 0.0154613187217613 0.0752702000105773 DataSet_03_258
GPC3 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 2.11765 1.08246 0.0784944906533215 0.597901606717941 DataSet_04_001
GPC3 E4F1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.0649351 -3.94486 0.0380430824795771 0.46816156992682 DataSet_04_007
GPC3 ERN1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.038961 -4.68182 0.0161815151094254 0.58778237666531 DataSet_04_009
GPC3 SMAD2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.18421 -2.44057 0.0690928274795445 0.179958032497217 DataSet_04_018
GPC3 HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.2 1.1375 0.677163303824724 0.897166132346016 DataSet_02_75
GPC3 EZH2 knockdown Uterus Ishikawa (ISK) cell 0.517632 -0.95 - - DataSet_03_324
GPC3 ELF3 CRISPR Bile_duct HBDEC2 0.58211 -0.780636 9.818592e-05 1.205798e-03 DataSet_03_304
GPC3 SNAI2 shRNA Pancreas KLM1 0.484121 -1.04656 4.510000e-03 0.13517867 DataSet_03_307
GPC3 ACTR5 siRNA Muscle RD 1.5536 0.635612 - - DataSet_03_343
GPC3 INO80 siRNA Muscle RD 0.485649 -1.04201 - - DataSet_03_344
GPC3 TET1 CRISPR Mammary_gland MDA-MB-231 30.7023 4.94028 5.382431e-01 7.201435e-01 DataSet_03_347
GPC3 ETV5 knockdown Colon HT29 1.67073 0.74048 7.759013e-02 0.292264353 DataSet_03_353
GPC3 TET1 CRISPR Mammary_gland Hs578T 2.98431 1.5774 4.589129e-01 6.456067e-01 DataSet_03_355
GPC3 PTPN14 CRISPR Brain U5-NPC 0.5 -1 2.871935e-01 0.50665633 DataSet_03_357
GPC3 TP53 CRISPR Brain U5-NPC 2.33333 1.22239 1.640738e-01 2.992689e-01 DataSet_03_358
GPC3 NCOA2 siRNA Uterus endometrial stromal cells 3 1.58496 0.2909998585 1 DataSet_03_360
GPC3 ZFP36L1 siRNA Urinary_bladder J82 1.86667 0.900464 - - DataSet_03_371
GPC3 E2F1 siRNA Nasopharynx HK1 0.4 -1.32193 6.457429e-01 1.000000e+00 DataSet_03_373
GPC3 ZNF213 siRNA Mammary_gland MCF7 0.00508889 -7.61843 6.100207e-02 4.829280e-01 DataSet_03_376
GPC3 SMARCA2 shRNA Lung NCI-H1944 9 3.16992 5.010260e-02 3.906628e-01 DataSet_03_377
GPC3 DDX5 shRNA Stomach HGC-27 0.425 -1.23447 - - DataSet_03_379
GPC3 TCF19 CRISPR Oral_squamous CAL27 0.247286 -2.01575 3.427362e-01 0.6401095761 DataSet_03_383
GPC3 YY1 shRNA Brain GSC1517 9 3.16992 - - DataSet_03_384
GPC3 NFKBIA shRNA Bone_marrow U2OS 0.0953115 -3.39121 1.784536e-01 0.87005461 DataSet_03_389
GPC3 KDM5A CRISPR Lung GLC16 2.73021 1.44901 3.037016e-03 0.024217232 DataSet_03_392
GPC3 TLE4 CRISPR Lymph CAR T Cell 0.483486 -1.04845 3.255821e-01 0.64801780 DataSet_03_398
GPC3 SUMO1 CRISPR Bone_marrow U2OS 0.402062 -1.31451 2.366078e-03 2.342785e-02 DataSet_03_401
GPC3 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 1.52369 0.60757 1.672982e-01 0.3746656 DataSet_03_403
GPC3 TFAP2A knockout Embryo H9 0.543403 -0.879906 8.490622e-03 0.06143215 DataSet_03_405
GPC3 SATB2 CRISPR Colon Colon organoid 0.55303 -0.85457 1.648283e-01 0.95735254 DataSet_03_406
GPC3 STRAP knockout Nerve SK-N-AS 3.41869 1.77345 - - DataSet_03_409
GPC3 SIRT1 siRNA Pancreas PANC1 2.2 1.1375 6.379943e-01 0.758794366 DataSet_03_410
GPC3 E2F1 siRNA Prostate LNCaP 0.51746 -0.95048 1.260592e-03 0.1347930883 DataSet_03_413
GPC3 ZKSCAN3 CRISPR Colon HCT116 0.520548 -0.941897 1.428480e-01 0.554410263 DataSet_03_415
GPC3 NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 2.93929 1.55547 3.631001e-03 0.028399983 DataSet_03_418
GPC3 FOXK2 shRNA Ovary OVCAR-5 0.206897 -2.27302 7.560220e-03 0.09598359 DataSet_03_419
GPC3 PRDM1 CRISPR Lymph CD8+ T cells 1.53521 0.618437 - - DataSet_03_421
GPC3 MAEL CRISPR Liver Alexander cells 6.65989 2.7355 - - DataSet_03_423
GPC3 FOXP3 CRISPR Peripheral_blood Naive Treg 4 2 1.242892e-01 0.461701750 DataSet_03_427
GPC3 LHX2 shRNA Bone_marrow ES-derived RPE cells 0.230769 -2.11548 2.058345e-02 1.000000e+00 DataSet_03_428
GPC3 USP7 shRNA Skin xenograft cells 0.495815 -1.01213 0.29515684 0.4412391 DataSet_03_431
GPC3 PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.56 -0.836501 - - DataSet_03_432
GPC3 EP300 knockout Pancreas HPAF-II orthotopic cells 0.354167 -1.4975 1.867880e-01 3.700295e-01 DataSet_03_436
GPC3 SUFU shRNA Mammary_gland HCC1954 cells 4 2 0.0839818560 0.6151644 DataSet_03_437
GPC3 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 1.53915 0.622135 1.072653e-01 0.90558273 DataSet_03_439
GPC3 SETDB1 shRNA Colon HCT116 0.525971 -0.926945 - - DataSet_03_440
GPC3 ARID1A shRNA Bile_duct MMNK1 0.590183 -0.760766 3.691499e-01 0.584690921 DataSet_03_458
GPC3 SOX9 knockout Liver HuH7 2.24037 1.16374 5.555483e-04 6.149446e-03 DataSet_03_463
GPC3 PARP1 knockout Embryo_kidney HEK293a 0.607199 -0.71976 6.729698e-05 4.756927e-04 DataSet_03_464
GPC3 SMARCA1 Cas13 Embryo_kidney HEK293T 0.497455 -1.00736 - - DataSet_03_466
GPC3 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 1.84182 0.881128 - - DataSet_03_467
GPC3 EZH2 siRNA Umbilical_vein HUVEC 5 2.32193 2.931918e-01 0.573763964 DataSet_03_473
GPC3 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 2.11765 1.08246 0.1985176 0.6474311 DataSet_04_072
Regulation Region
 
T(co)Fs that significantly regulate ERN1 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of GPC3
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines