Gene Overview
Target Gene: HAS2
NCBI Official Symbol: HAS2
Entrez ID: 3037
Ensembl ID: ENSG00000170961
Gene Full Name: hyaluronan synthase 2
Strand: -
Gene Locus: 8q24.13
External Links:

HAS2 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate HAS2   
T(co)Fs that Repress HAS2
The Intensity of the Gene Regulated by T(co)Fs:
HAS2-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
HAS2 SPDEF shRNA Mammary_gland MCF7 1.85494 0.89137 0.97955 0.99999 DataSet_01_107
HAS2 HOXA1 siRNA Lung_fibroblast IMR-90 0.45624 -1.13212 0.01322 0.12192 DataSet_01_110
HAS2 FOXM1 siRNA Central_nervous_system U87 10.2751 3.36108 - - DataSet_01_122
HAS2 ZNF91 siRNA Gastrointestinal_tissue GIST-T1 1.63299 0.70752 0.00014 0.00577 DataSet_01_123
HAS2 ZNF100 siRNA Gastrointestinal_tissue GIST-T1 1.58141 0.66122 0.00023 0.00994 DataSet_01_124
HAS2 ZNF43 siRNA Gastrointestinal_tissue GIST-T1 1.65904 0.73034 0.00011 0.00714 DataSet_01_125
HAS2 ZNF254 siRNA Gastrointestinal_tissue GIST-T1 1.82654 0.86911 2.68958e-05 0.00146 DataSet_01_127
HAS2 ZNF431 siRNA Gastrointestinal_tissue GIST-T1 2.60205 1.37965 5.24952e-07 0.00014 DataSet_01_128
HAS2 ZNF708 siRNA Gastrointestinal_tissue GIST-T1 1.96848 0.97708 1.02302e-05 0.00147 DataSet_01_130
HAS2 ID1 shRNA Neuroepithelium GSC2 0.37471 -1.41615 7.42604e-13 4.67608e-11 DataSet_01_133
HAS2 ID1 shRNA Neuroepithelium GSC8 0.37228 -1.42555 5.00969e-10 2.30206e-09 DataSet_01_134
HAS2 SOX4 shRNA Parotid_gland ACC3 1.63481 0.70912 0.17838 0.96328 DataSet_01_140
HAS2 NR3C1 siRNA Uterus Endometrial stromal cells 1.59107 0.67 0.10575 0.99972 DataSet_01_141
HAS2 GLI2 siRNA Bone_marrow U2OS 1.61922 0.6953 - - DataSet_01_143
HAS2 SF1 siRNA Adrenal_gland H295R/TR 0.6355 -0.65405 6.27282e-05 0.00186 DataSet_01_146
HAS2 TEAD4 shRNA Stomach SNU216 0.61618 -0.69858 - - DataSet_01_151
HAS2 ZFX shRNA Central_nervous_system DAOY 1.87113 0.90391 0.00229 0.99991 DataSet_01_157
HAS2 GABPA shRNA Prostate C4-2B 985.645 9.94492 0.23532 0.43934 DataSet_01_190
HAS2 GABPA shRNA Prostate LNCaP 687.106 9.42439 0.46225 0.7048 DataSet_01_191
HAS2 CREB1 shRNA Parotid_gland H3118 MEC 1.89776 0.9243 0.62988 0.85467 DataSet_01_194
HAS2 CREB1 shRNA Parotid_gland HSY 1.86082 0.89594 0.25202 0.91645 DataSet_01_195
HAS2 TP63 siRNA Immortalized_keratinocyte HaCaT RG 0.51536 -0.95635 - - DataSet_01_196
HAS2 TP63 siRNA Immortalized_keratinocyte HaCaT RG 1.55827 0.63994 - - DataSet_01_197
HAS2 TP63 siRNA Head_and_neck SCC-1 0.13527 -2.88613 - - DataSet_01_198
HAS2 TP63 siRNA Head_and_neck SCC-1 2.19003 1.13095 - - DataSet_01_199
HAS2 TP63 siRNA Head_and_neck SCC-6 1.62613 0.70145 - - DataSet_01_202
HAS2 HIC1 shRNA Mammary_gland HBL100 0.21055 -2.24776 - - DataSet_01_205
HAS2 MITF shRNA Skin COLO829 0.32505 -1.62127 0.03045 0.14906 DataSet_01_207
HAS2 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 1.69998 0.76552 - - DataSet_01_208
HAS2 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.48026 -1.0581 - - DataSet_01_210
HAS2 SNAI2 shRNA Skin Primary human keratinocytes 0.0589 -4.08568 7.88733e-05 0.00711 DataSet_01_225
HAS2 JUN shRNA Soft_tissue LP6 0.39737 -1.33145 0.02048 0.40289 DataSet_01_230
HAS2 MYC siRNA White_adipose_tissue Adipose stem cells 0.49876 -1.00359 3.10539e-08 2.41777e-05 DataSet_01_231
HAS2 TWIST1 shRNA Stomach CAF32 0.09748 -3.35868 1.13134e-05 0.01146 DataSet_01_253
HAS2 TWIST1 shRNA Stomach CAF 0.32299 -1.63042 0.0772 0.5711 DataSet_01_254
HAS2 YBX1 shRNA Mammary_gland MDA 1.55453 0.63648 9.83431e-08 3.92187e-06 DataSet_01_255
HAS2 SOX4 shRNA Mammary_gland MDA-MB-231 0.61181 -0.70885 0.03233 0.22186 DataSet_01_260
HAS2 ZIC5 siRNA Skin A375 6.76871 2.75888 - - DataSet_01_284
HAS2 ZIC5 siRNA Skin SK-MEL-28 0.6045 -0.72618 - - DataSet_01_285
HAS2 SNAI2 siRNA Mammary_gland MCFDCIS 0.63821 -0.64791 0.19249 0.72568 DataSet_01_292
HAS2 POSTN shRNA Brain GSC272 1.66366 0.73436 0.29679 0.64874 DataSet_01_293
HAS2 TFAP4 siRNA Brain BE(2)-C 0.20324 -2.29874 0.34431 0.51625 DataSet_01_295
HAS2 SOX7 siRNA Umbilical_vein HUVEC 0.12501 -2.99987 0.08457 0.89788 DataSet_01_299
HAS2 SOX17 siRNA Umbilical_vein HUVEC 0.13104 -2.93194 0.04063 0.99998 DataSet_01_300
HAS2 PTEN shRNA Skin A431 0.17283 -2.53254 0.00258 0.07056 DataSet_01_301
HAS2 PTEN shRNA Lung HCC827 0.61934 -0.69119 0.10904 0.61605 DataSet_01_302
HAS2 NR2E1 shRNA Neuroepithelium PBT003 0.61442 -0.70271 0.08547 0.51248 DataSet_01_306
HAS2 OVOL2 siRNA Corneal_epithelial Corneal epithelial cells 0.60562 -0.7235 0.27309 0.48907 DataSet_01_313
HAS2 ARNT siRNA Upper_aerodigestive_tract HSC3 0.21581 -2.21217 - - DataSet_01_315
HAS2 ELK3 shRNA Mammary_gland MDA-MB-231 3.20976 1.68247 3.05807e-06 6.28612e-05 DataSet_01_318
HAS2 MYC siRNA Colon HCT116 5.14953 2.36444 0.18109 0.2397 DataSet_01_324
HAS2 HOXC6 siRNA Prostate LNCaP 0.35535 -1.49267 0.15553 0.99927 DataSet_01_333
HAS2 STAT3 siRNA Liver LX-2 2.08316 1.05877 0.00048 0.00387 DataSet_01_334
HAS2 HIF1A siRNA Oral_cavity OEC-M1 2.51222 1.32897 0.21251 0.85151 DataSet_01_348
HAS2 SOX2 siRNA Embryo Undifferentiated hESCs 1.7245 0.78618 - - DataSet_01_350
HAS2 ETV4 shRNA Prostate PC3 1.50012 0.58507 - - DataSet_01_356
HAS2 CDX2 siRNA Colon COLO320 0.40785 -1.29389 - - DataSet_01_357
HAS2 GTF2B siRNA Cervix HeLa 1.89723 0.92389 - - DataSet_01_362
HAS2 AR siRNA Prostate LNCaP 0.46056 -1.11854 0.0795670315304479 1 DataSet_03_005
HAS2 ASCL1 siRNA Lung DMS79 0.240964 -2.05311 0.0484159035657392 0.67028012814667 DataSet_03_016
HAS2 BCL6 siRNA Lymph Pfeiffer DLBCL 0.635948 -0.653018 0.373531117312184 0.785610125225845 DataSet_03_026
HAS2 CASP8AP2 siRNA Bone_marrow hTERT-RPE1 1.76888 0.822837 0.0443151435447581 0.576895139509709 DataSet_03_030
HAS2 CEBPB siRNA Embryo hESC 3.07457 1.62039 0.0619176396533864 0.399596483983177 DataSet_03_049
HAS2 ESR1 siRNA Uterus Endometrial stromal cells 1.69879 0.76451 0.0139144007763757 1 DataSet_03_070
HAS2 ETS1 siRNA Fibroblasts WI38 2.1198 1.08393 0.0727960836652384 0.240667285974009 DataSet_03_073
HAS2 ETS1 siRNA Fibroblasts WI38 2.61625 1.3875 0.0208715404443873 0.117234161517075 DataSet_03_074
HAS2 FOXM1 siRNA Aorta Vascular smooth muscle cells 0.366198 -1.4493 - - DataSet_03_090
HAS2 GATA6 siRNA Stomach AGS 1.78522 0.836099 0.283415949819179 0.757596521901297 DataSet_03_108
HAS2 HIC1 CRISPR Prostate PC3 0.589248 -0.763052 - - DataSet_03_118
HAS2 HIF3A siRNA Liver Hep3B 2.24233 1.165 0.00402312648028138 1 DataSet_03_120
HAS2 HIF3A siRNA Liver Hep3B 2.24233 1.165 0.00402312648028138 1 DataSet_03_121
HAS2 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 4.06995 2.02501 0.304675805037799 0.999948959532916 DataSet_03_134
HAS2 JUN siRNA Fibroblasts WI38 3.05025 1.60893 0.00141243315491083 0.0188698167349385 DataSet_03_140
HAS2 JUN siRNA Fibroblasts WI38 3.05025 1.60893 0.0014112695553179 0.0187485705812239 DataSet_03_141
HAS2 KLF5 siRNA Stomach KatoIII 1.72754 0.788716 0.00192158439207809 0.132522006402711 DataSet_03_150
HAS2 MEF2D shRNA Liver HuH7 3.04212 1.60508 - - DataSet_03_162
HAS2 MEF2D siRNA Liver HuH7 1.59971 0.677808 - - DataSet_03_163
HAS2 MITF siRNA Skin SK-MEL-5 0.222592 -2.16753 1.13605386725872e-20 1.08169368971039e-16 DataSet_03_168
HAS2 MYB siRNA Cord_Blood CD34+ progenitor cells 12.7528 3.67274 - - DataSet_03_170
HAS2 MYC siRNA Colon HT29 5.12713 2.35815 - - DataSet_03_177
HAS2 MYC siRNA Central_nervous_system DAOY M2.1 13.2805 3.73123 2.25695529283936e-10 1.01821597638409e-07 DataSet_03_178
HAS2 MYCN siRNA Brain BE(2)C cells 1.54714 0.6296 - - DataSet_03_188
HAS2 NFAT5 siRNA Synovial Primary fibroblast-like synoviocytes 0.586592 -0.769571 0.123868447561384 0.501013716471686 DataSet_03_194
HAS2 NPAT siRNA Bone_marrow hTERT-RPE1 1.55218 0.634299 0.00309901367185286 0.0840086565542926 DataSet_03_200
HAS2 NR4A3 siRNA Pancreas 1.1B4 2.1892 1.1304 6.38430106923496e-06 0.000109129784116556 DataSet_03_203
HAS2 PHB shRNA Embryo Embryonic stem cells (ESCs) 0.599133 -0.739051 0.0016180939052091 0.00792576872139858 DataSet_03_211
HAS2 PRRX1 CRISPR Neuroblastoma 691-MES 2.3639 1.24117 0.234903533839374 0.894427234823585 DataSet_03_217
HAS2 RELB shRNA Ovary SKOV3 1.65542 0.727193 0.146985037551885 0.999733815028798 DataSet_03_226
HAS2 SOX11 siRNA Lung_fibroblast NHLF 0.111139 -3.16957 0.0103326106307584 0.307192442951033 DataSet_03_237
HAS2 SOX11 siRNA Lung_fibroblast NHLF 0.108452 -3.20488 0.0705513564686651 0.378455378000996 DataSet_03_238
HAS2 SOX2 siRNA Lung H520 1.75744 0.813478 - - DataSet_03_240
HAS2 SOX2 siRNA Lung LK2 1.98025 0.985685 - - DataSet_03_241
HAS2 SOX2 siRNA Embryo 2102Ep 4.03386 2.01216 2.43979428153613e-08 8.4777389057377e-06 DataSet_03_242
HAS2 SOX2 siRNA Embryo NTera-2 1.98834 0.991563 5.03711596817869e-05 0.00430701273739607 DataSet_03_243
HAS2 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 13.2 3.72247 - - DataSet_03_246
HAS2 TET1 siRNA Embryo NCCIT 2.01482 1.01065 1.45174607127282e-05 0.00186656506397754 DataSet_03_269
HAS2 TET2 siRNA Embryo NCCIT 2.71528 1.4411 1.67766810774417e-06 0.00047181673934532 DataSet_03_270
HAS2 TFE3 siRNA Kidney UOK257-2 1.65254 0.724682 - - DataSet_03_275
HAS2 TP63 siRNA Foreskin Neonatal foreskin keratinocytes 0.590979 -0.758821 0.132200819313882 0.741457915102858 DataSet_03_282
HAS2 TWIST1 siRNA Bone_marrow MSCs 0.662234 -0.594587 - - DataSet_03_283
HAS2 ZHX2 shRNA Kidney 786-O 1.75952 0.815185 0.0164877889414728 0.0821059080910199 DataSet_03_287
HAS2 EZH2 shRNA Colon SW480 3.46043 1.79095 - - DataSet_03_298
HAS2 ELF3 CRISPR Bile_duct HBDEC2 1.65541 0.727185 1.411867e-01 2.192548e-01 DataSet_03_304
HAS2 ELF3 knockdown Bile_duct HBDEC2 2.91333 1.54267 1.017970e-03 2.069913e-02 DataSet_03_305
HAS2 HDAC5 siRNA Liver human hepatocytes 1.64467 0.7178 1.341603e-06 1.259219e-04 DataSet_03_346
HAS2 SNAI2 shRNA Pancreas KLM1 0.627171 -0.673069 9.527587e-03 0.16257410 DataSet_03_307
HAS2 INO80 siRNA Muscle RD 2.22823 1.1559 - - DataSet_03_344
HAS2 AEBP1 siRNA Central_nervous_system U87MG 1.69523 0.761481 1.715373e-01 0.9999434 DataSet_03_338
HAS2 DNMT1 shRNA Lung hTERT-immortalised adult fibroblasts 0.498274 -1.00499 2.948939e-03 1.336682e-01 DataSet_03_311
HAS2 ARID3B CRISPR Colon HCT15 0.534814 -0.90289 - - DataSet_03_335
HAS2 TET1 CRISPR Mammary_gland MDA-MB-231 46.5263 5.53998 1.918696e-04 4.206809e-03 DataSet_03_347
HAS2 ETV5 knockdown Colon HT29 8.27586 3.04891 9.026900e-03 0.110222966 DataSet_03_353
HAS2 TET1 CRISPR Mammary_gland Hs578T 0.610849 -0.711112 1.262813e-01 2.775451e-01 DataSet_03_355
HAS2 PTPN14 CRISPR Brain U5-NPC 0.444379 -1.17014 4.045210e-02 0.26847802 DataSet_03_357
HAS2 TP53 CRISPR Brain U5-NPC 4.74258 2.24567 2.269707e-02 1.651722e-01 DataSet_03_358
HAS2 EP300 shRNA Mammary_gland MCF10AT 21.2727 4.41093 7.888562e-04 0.019179932 DataSet_03_364
HAS2 TP53 knockout Stomach SNU1 0.38666 -1.37086 0.8220295294 1.0000000 DataSet_03_365
HAS2 ZNF148 shRNA Mammary_gland MDA-MB-231 0.400575 -1.31985 9.058330e-04 0.027299002 DataSet_03_366
HAS2 ZFP36L1 siRNA Urinary_bladder J82 2.875 1.52356 - - DataSet_03_371
HAS2 GLI1 siRNA Skeletal_muscle RMS13 0.323683 -1.62735 5.089056e-04 0.015197540 DataSet_03_375
HAS2 SMARCA2 shRNA Lung NCI-H1944 2.86337 1.51771 8.425463e-05 6.678769e-02 DataSet_03_377
HAS2 EZH2 CRISPR Ovary SKOV3 4.25 2.08746 3.380351e-02 0.1544680065 DataSet_03_378
HAS2 NFKB2 siRNA Bone_marrow U2OS 0.663158 -0.592576 1.394452e-01 0.45058545 DataSet_03_381
HAS2 DNMT1 siRNA Skin Human melanoma cells 0.446296 -1.16393 1.911454e-06 3.987565e-05 DataSet_03_382
HAS2 KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 3.15072 1.65568 0.1929248458 0.8388073 DataSet_03_387
HAS2 TRIM8 siRNA Mammary_gland MCF7 2.6 1.37851 1.190117e-01 0.2829892191 DataSet_03_388
HAS2 NFKBIA shRNA Bone_marrow U2OS 0.446708 -1.1626 2.309209e-01 0.87005461 DataSet_03_389
HAS2 ILF2 siRNA Stomach SGC-7901 6.55556 2.71272 0.3148848387 0.50770212 DataSet_03_393
HAS2 BMI1 shRNA Bile_duct QBC-939 0.56754 -0.817206 3.273693e-02 0.0980182663 DataSet_03_395
HAS2 IKZF2 CRISPR Lymph CAR T Cell 0.65823 -0.603336 7.991474e-01 0.965963349 DataSet_03_397
HAS2 RELA CRISPR Brain T30 3.73038 1.89932 0.1508164257 0.8400824 DataSet_03_399
HAS2 HMGA1 shRNA Bile_duct HUCCT1 15.25 3.93074 3.170754e-03 0.066748297 DataSet_03_400
HAS2 SUMO1 CRISPR Bone_marrow U2OS 0.142857 -2.80735 8.875503e-03 5.169518e-02 DataSet_03_401
HAS2 STRAP knockout Nerve SK-N-AS 0.491347 -1.02518 - - DataSet_03_409
HAS2 E2F6 shRNA Liver HuH7 0.650448 -0.620495 - - DataSet_03_412
HAS2 ZKSCAN3 CRISPR Colon HCT116 0.557522 -0.842899 3.979280e-02 0.391042750 DataSet_03_415
HAS2 FOXK2 shRNA Ovary OVCAR-5 4 2 5.530843e-02 0.19324885 DataSet_03_419
HAS2 USP7 shRNA Skin xenograft cells 0.463796 -1.10844 0.26612777 0.4348960 DataSet_03_431
HAS2 EP300 knockout Pancreas HPAF-II orthotopic cells 0.654594 -0.611327 1.443930e-01 3.086188e-01 DataSet_03_436
HAS2 CIC knockout Brain Immortalized Astrocyte Cells 1.84955 0.887174 7.613220e-01 9.239662e-01 DataSet_03_438
HAS2 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 0.228804 -2.12782 7.818359e-01 0.99948874 DataSet_03_439
HAS2 PHF14 siRNA Mammary_gland MDA-MB-231 1.51865 0.60279 0.0550264981 0.4395157 DataSet_03_443
HAS2 CAMTA1 knockout Embryo_kidney HEK293T 2.2 1.1375 2.275107e-02 0.13765336 DataSet_03_448
HAS2 RELB CRISPR Colon SW480 4.05214 2.01869 3.023514e-03 4.030996e-02 DataSet_03_449
HAS2 SMARCA2 shRNA Lung HCC2302 0.414015 -1.27224 2.731881e-02 3.476193e-02 DataSet_03_455
HAS2 PPARG siRNA Aortic_valve Valvular endothelial cell 0.515606 -0.955661 8.112522e-02 4.393090e-01 DataSet_03_456
HAS2 SREBF2 siRNA Umbilical_vein HUVEC 1.68958 0.756668 8.476409e-01 9.646007e-01 DataSet_03_457
HAS2 ARID1A shRNA Bile_duct MMNK1 0.381768 -1.38923 8.376702e-02 0.302949069 DataSet_03_458
HAS2 SOX9 knockout Liver HuH7 6.18182 2.62803 3.329828e-04 4.521007e-03 DataSet_03_463
HAS2 PARP1 knockout Embryo_kidney HEK293a 18.2079 4.18649 1.559598e-14 5.721526e-12 DataSet_03_464
HAS2 SMARCA1 Cas13 Embryo_kidney HEK293T 2.07407 1.05247 - - DataSet_03_466
HAS2 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 1.81481 0.859822 - - DataSet_03_467
HAS2 SMARCA1 shRNA Embryo_kidney HEK293T 4.85185 2.27854 - - DataSet_03_468
HAS2 EZH2 siRNA Umbilical_vein HUVEC 4.55556 2.18763 1.645418e-03 0.068929803 DataSet_03_473
Regulation Region
 
T(co)Fs that significantly regulate MYC by the evidences of both expression and ChIP-seq/motif
Expression Atlas of HAS2
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines