Gene Overview
Target Gene: HLA-DOA
NCBI Official Symbol: HLA-DOA
Entrez ID: 3111
Ensembl ID: ENSG00000204252
Gene Full Name: major histocompatibility complex, class II, DO alpha
Strand: -
Gene Locus: 6p21.32
External Links:

HLA-DOA Significantly Regulated by These T(co)Fs

T(co)Fs that Activate HLA-DOA   
T(co)Fs that Repress HLA-DOA
The Intensity of the Gene Regulated by T(co)Fs:
HLA-DOA-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
HLA-DOA HOXA1 siRNA Lung_fibroblast IMR-90 2.86578 1.51893 0.11427 0.3676 DataSet_01_110
HLA-DOA ZIC2 siRNA Pancreas PANC1 1.88897 0.9176 - - DataSet_01_121
HLA-DOA FOXM1 siRNA Central_nervous_system U87 2.47079 1.30497 - - DataSet_01_122
HLA-DOA ZFX shRNA Haematopoietic_and_lymphoid_tissue NOMO-1 1.57902 0.65903 0.39968 0.99999 DataSet_01_144
HLA-DOA HSF1 shRNA Skin A375 0.5625 -0.83007 0.00218 0.02204 DataSet_01_155
HLA-DOA GATA3 siRNA Peripheral_blood CD4+ T cells 0.516 -0.95455 0.00241 0.09349 DataSet_01_163
HLA-DOA JUN siRNA Peripheral_blood CD4+ T cells 335.705 8.39105 0.06852 0.23243 DataSet_01_164
HLA-DOA MAF siRNA Peripheral_blood CD4+ T cells 1.50219 0.58707 0.01235 0.11986 DataSet_01_165
HLA-DOA NFATC3 siRNA Peripheral_blood CD4+ T cells 1.58344 0.66306 0.02996 0.17492 DataSet_01_166
HLA-DOA NFKB1 siRNA Peripheral_blood CD4+ T cells 0.62511 -0.67783 0.01529 0.34764 DataSet_01_167
HLA-DOA TP53 siRNA Lung SAECs 1.61167 0.68856 0.1333 0.54379 DataSet_01_175
HLA-DOA TP63 siRNA Immortalized_keratinocyte HaCaT RG 1.85361 0.89034 - - DataSet_01_197
HLA-DOA HIC1 shRNA Mammary_gland HBL100 2.27728 1.18731 - - DataSet_01_205
HLA-DOA IRX1 shRNA Bone_marrow 143B 0.65654 -0.60704 0.00996 0.10495 DataSet_01_227
HLA-DOA FOXO3 siRNA Pancreas PANC1 0.54098 -0.88635 - - DataSet_01_267
HLA-DOA SIX4 siRNA Ovary PEO1 0.57561 -0.79684 0.05611 0.2115 DataSet_01_269
HLA-DOA POSTN shRNA Brain GSC272 2.05008 1.03568 0.15007 0.57159 DataSet_01_293
HLA-DOA TFAP4 siRNA Brain BE(2)-C 0.11866 -3.07511 0.23944 0.51625 DataSet_01_295
HLA-DOA OVOL2 siRNA Corneal_epithelial Corneal epithelial cells 1.69366 0.76015 0.00167 0.17596 DataSet_01_313
HLA-DOA FIP1L1 shRNA Liver HepG2 0.03333 -4.90689 0.45823 0.56401 DataSet_02_103
HLA-DOA HDGF shRNA Liver HepG2 12 3.58496 0.01342 0.10031 DataSet_02_104
HLA-DOA TAF15 shRNA Liver HepG2 7.5 2.90689 5.25108e-05 0.01075 DataSet_02_106
HLA-DOA SSB shRNA Liver HepG2 3.09091 1.62803 0.3428 0.41539 DataSet_02_107
HLA-DOA HNRNPUL1 shRNA Liver HepG2 12.5714 3.65208 0.00573 0.03209 DataSet_02_109
HLA-DOA XRCC5 shRNA Liver HepG2 3.75 1.90689 0.83364 0.90743 DataSet_02_114
HLA-DOA TARDBP shRNA Liver HepG2 0.5 -1 0.48574 0.5754 DataSet_02_116
HLA-DOA CEBPZ shRNA Liver HepG2 0.13333 -2.90689 0.26531 1 DataSet_02_118
HLA-DOA EWSR1 shRNA Liver HepG2 8 3 0.46369 0.58597 DataSet_02_122
HLA-DOA FUS shRNA Liver HepG2 11 3.45943 0.05352 0.18061 DataSet_02_124
HLA-DOA HNRNPLL shRNA Liver HepG2 0.04545 -4.45943 0.1089 0.1715 DataSet_02_125
HLA-DOA SNRNP70 shRNA Liver HepG2 4.86364 2.28204 0.04106 0.10808 DataSet_02_126
HLA-DOA SRSF3 shRNA Liver HepG2 0.22727 -2.1375 0.12463 0.26365 DataSet_02_127
HLA-DOA PRPF4 shRNA Liver HepG2 0.05556 -4.16993 0.05612 0.13656 DataSet_02_128
HLA-DOA TBL1XR1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.1885 1 DataSet_02_178
HLA-DOA ARID3A siRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.21246 1 DataSet_02_193
HLA-DOA ZFX siRNA Mammary_gland MCF7 0.15385 -2.70044 0.14828 0.36714 DataSet_02_206
HLA-DOA BCL6 siRNA Lymph OCI-Ly7 DLBCL 1.50798 0.59262 0.00328323031320526 0.411274484230066 DataSet_03_025
HLA-DOA FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 0.659107 -0.601415 - - DataSet_03_096
HLA-DOA GATA6 siRNA Stomach AGS 0.643539 -0.635901 0.0287682675850507 0.413251362113613 DataSet_03_108
HLA-DOA IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 0.628983 -0.668907 0.343428301696795 0.999948959532916 DataSet_03_134
HLA-DOA MEF2D shRNA Liver HuH7 1.54521 0.6278 - - DataSet_03_162
HLA-DOA MEF2D siRNA Liver HuH7 0.639364 -0.64529 - - DataSet_03_163
HLA-DOA MTA2 siRNA Stomach SGC-7901 2.19175 1.13208 - - DataSet_03_169
HLA-DOA PHB shRNA Embryo Embryonic stem cells (ESCs) 0.402965 -1.31127 0.000211960168243068 0.0019982574851126 DataSet_03_211
HLA-DOA RELB siRNA Immortalized_keratinocyte HaCaT 0.575694 -0.796627 2.86296997067084e-05 0.000446638804892482 DataSet_03_227
HLA-DOA STAT3 siRNA Prostate LNCaP 3.38032 1.75716 0.12654509059382 0.173174857388462 DataSet_03_262
HLA-DOA ZNF746 siRNA Colon HCT116 0.643049 -0.637 - - DataSet_03_293
HLA-DOA CTCF CRISPR Liver HepG2 2.63636 1.39855 0.112420032566509 0.87075549477253 DataSet_04_027
HLA-DOA E4F1 CRISPR Liver HepG2 10 3.32193 0.268952252405172 0.553727015898497 DataSet_04_028
HLA-DOA ERN1 CRISPR Liver HepG2 1.75 0.807355 0.000185675115817921 0.0445066549429701 DataSet_04_029
HLA-DOA FUBP1 shRNA Liver HepG2 2.75 1.45943 0.0209680647216302 0.405437269786979 DataSet_04_030
HLA-DOA MECP2 CRISPR Liver HepG2 2.625 1.39232 0.000195244387557726 0.0916216829345888 DataSet_04_031
HLA-DOA NFX1 CRISPR Liver HepG2 3.67391 1.87732 0.0510255194188728 0.102978049057415 DataSet_04_032
HLA-DOA PAN2 CRISPR Liver HepG2 1.52381 0.607683 0.470747176410261 0.62799666828858 DataSet_04_033
HLA-DOA SMAD2 CRISPR Liver HepG2 0.285714 -1.80736 0.0808378582579004 0.623099080282865 DataSet_04_034
HLA-DOA SMAD5 CRISPR Liver HepG2 0.523809 -0.932886 0.207376538041013 0.599861384694953 DataSet_04_036
HLA-DOA SRPK2 CRISPR Liver HepG2 3.875 1.9542 0.00540952926703172 0.120603738537091 DataSet_04_037
HLA-DOA YBX1 CRISPR Liver HepG2 11.3333 3.5025 0.113108993489633 0.972884761036538 DataSet_04_039
HLA-DOA DDX20 CRISPR Liver HepG2 5.375 2.42627 0.016848854618293 0.0844434171517367 DataSet_04_043
HLA-DOA APTX CRISPR Liver HepG2 2.63636 1.39855 0.157169756448861 0.792144925815468 DataSet_04_069
HLA-DOA CHCHD3 CRISPR Liver HepG2 18 4.16993 0.103135889979407 0.49126430933096 DataSet_04_067
HLA-DOA CNOT7 CRISPR Liver HepG2 0.52381 -0.932886 0.206836621589074 0.356715098022783 DataSet_04_045
HLA-DOA DNMT3B CRISPR Liver HepG2 3 1.58496 0.0413326076190164 0.202546982427198 DataSet_04_044
HLA-DOA RIOK2 CRISPR Liver HepG2 5 2.32193 0.251601482125375 0.985876322359482 DataSet_04_070
HLA-DOA SEPT11 CRISPR Liver HepG2 6.53333 2.70782 0.13138182616641 0.361124912897618 DataSet_04_068
HLA-DOA ABT1 shRNA Liver HepG2 0.152174 -2.71621 0.103788394261542 0.19340791559813 DataSet_04_052
HLA-DOA CALR shRNA Liver HepG2 5 2.32193 0.444949182373438 0.587719467709127 DataSet_04_053
HLA-DOA DDX1 shRNA Liver HepG2 2.57143 1.36257 0.549715605856326 0.75543071540435 DataSet_04_057
HLA-DOA PRPF6 shRNA Liver HepG2 6.25 2.64386 0.16000342402278 0.350682504494927 DataSet_04_056
HLA-DOA YBX3 shRNA Liver HepG2 4.28571 2.09954 0.27114342227523 0.463497337086345 DataSet_02_98
HLA-DOA CITED2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 3.4375 1.78136 0.343855161159625 0.601987288403653 DataSet_02_38
HLA-DOA ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.375 1.24793 0.481349244855677 0.654282497584146 DataSet_02_34
HLA-DOA HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.72222 0.784271 0.62963565744529 0.87472072113452 DataSet_02_75
HLA-DOA HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 11.625 3.53916 0.0189633138980663 0.46329392868335 DataSet_02_45
HLA-DOA LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 3.5 1.80735 0.150707042561362 0.284659162035415 DataSet_02_35
HLA-DOA NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 5.15625 2.36632 0.323456552400203 0.577731740736594 DataSet_02_32
HLA-DOA SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.125 -3 0.322771600263109 0.483042228442416 DataSet_02_47
HLA-DOA SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 11.6667 3.54432 0.339329499207528 0.736987215274174 DataSet_02_49
HLA-DOA TBL1XR1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.125 -3 0.374749283046363 0.565688405184181 DataSet_02_43
HLA-DOA TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2 1 0.569160610375769 0.71993277572776 DataSet_02_53
HLA-DOA ELF3 CRISPR Bile_duct HBDEC2 0.579138 -0.788021 1.284223e-02 3.942112e-02 DataSet_03_304
HLA-DOA SNAI2 shRNA Pancreas KLM1 0.541498 -0.884972 1.349737e-01 0.47905138 DataSet_03_307
HLA-DOA ACTR5 siRNA Muscle RD 0.597333 -0.743393 - - DataSet_03_343
HLA-DOA TET1 CRISPR Mammary_gland MDA-MB-231 19.609 4.29344 2.750450e-01 4.923562e-01 DataSet_03_347
HLA-DOA ETV5 knockdown Colon HT29 0.275362 -1.8606 3.122828e-02 0.204473616 DataSet_03_353
HLA-DOA TET1 CRISPR Mammary_gland Hs578T 0.56918 -0.813043 7.860994e-01 8.876776e-01 DataSet_03_355
HLA-DOA CREBBP CRISPR Brain U5-NPC 0.0651629 -3.93981 0.0074248555 0.7490853 DataSet_03_356
HLA-DOA PTPN14 CRISPR Brain U5-NPC 0.217742 -2.19931 2.286897e-02 0.25575097 DataSet_03_357
HLA-DOA TP53 CRISPR Brain U5-NPC 2.07268 1.0515 8.564598e-01 8.932382e-01 DataSet_03_358
HLA-DOA RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 5.39016 2.43033 6.249022e-04 4.159893e-02 DataSet_03_359
HLA-DOA NCOA3 siRNA Mammary_gland MDA-MB-231 0.109149 -3.19563 3.080040e-01 0.8040546 DataSet_03_361
HLA-DOA ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 2.19474 1.13405 5.172688e-01 6.167920e-01 DataSet_03_362
HLA-DOA TP53 knockout Stomach SNU1 0.0599389 -4.06036 0.6848526949 0.9787542 DataSet_03_365
HLA-DOA DNMT3A knockout Embryo_kidney HEK293T 0.663509 -0.591811 - - DataSet_03_369
HLA-DOA E2F1 siRNA Nasopharynx HK1 0.444444 -1.16992 2.385015e-01 9.047452e-01 DataSet_03_373
HLA-DOA SMARCA2 shRNA Lung NCI-H1944 2.12 1.08406 6.924623e-01 8.802169e-01 DataSet_03_377
HLA-DOA DNMT1 siRNA Skin Human melanoma cells 33.6922 5.07434 6.561130e-05 3.925621e-04 DataSet_03_382
HLA-DOA NFKBIA shRNA Bone_marrow U2OS 0.0125184 -6.31981 5.277325e-01 0.87005461 DataSet_03_389
HLA-DOA YY1 knockdown Liver HepG2 0.21875 -2.19265 2.367560e-01 3.979835e-01 DataSet_03_390
HLA-DOA ILF2 siRNA Stomach SGC-7901 0.1 -3.32193 0.1451458049 0.31662166 DataSet_03_393
HLA-DOA ASXL1 CRISPR Embryo iPSC 0.136678 -2.87114 0.0054572784 0.8024343 DataSet_03_394
HLA-DOA TLE4 CRISPR Lymph CAR T Cell 1.94668 0.961017 2.600791e-02 0.18700955 DataSet_03_398
HLA-DOA RELA CRISPR Brain T30 31.0761 4.95773 0.1099800597 0.8400824 DataSet_03_399
HLA-DOA EHF shRNA Stomach MKN7 0.0102625 -6.60647 - - DataSet_03_402
HLA-DOA JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 3.22222 1.68806 1.291231e-03 0.3033066 DataSet_03_403
HLA-DOA TFAP2A knockout Embryo H9 0.460687 -1.11814 4.687406e-03 0.04782946 DataSet_03_405
HLA-DOA SATB2 CRISPR Colon Colon organoid 2 1 7.304103e-01 1.00000000 DataSet_03_406
HLA-DOA CHD1 shRNA Prostate LNCaP 0.251514 -1.99129 2.986673e-02 3.860376e-01 DataSet_03_407
HLA-DOA MAP3K7 shRNA Prostate LNCaP 0.501567 -0.995486 3.133877e-01 5.466827e-01 DataSet_03_408
HLA-DOA ZKSCAN3 CRISPR Colon HCT116 0.3 -1.73697 2.417407e-02 0.323956189 DataSet_03_415
HLA-DOA RUNX2 shRNA Cord_blood Natural Killer Cell 0.0625 -4 2.298304e-02 0.793390621 DataSet_03_416
HLA-DOA NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 2 1 7.395684e-01 0.830693436 DataSet_03_418
HLA-DOA MAEL CRISPR Liver Alexander cells 0.25 -2 - - DataSet_03_423
HLA-DOA STAT5B CRISPR Embryo_kidney HEK293 0.640884 -0.641865 7.397720e-02 0.544378331 DataSet_03_424
HLA-DOA FOXP3 CRISPR Peripheral_blood Naive Treg 4.83277 2.27285 1.634495e-03 0.102851144 DataSet_03_427
HLA-DOA PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.280665 -1.83308 - - DataSet_03_432
HLA-DOA POU2AF1 CRISPR Lymph SUDHL4 2.48912 1.31564 1.446124e-04 0.006013355 DataSet_03_435
HLA-DOA FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 0.140351 -2.83289 3.038691e-01 0.90558273 DataSet_03_439
HLA-DOA HMG20A siRNA Mammary_gland MDA-MB-231 2.05085 1.03622 0.0018766642 0.1189065 DataSet_03_442
HLA-DOA PHF14 siRNA Mammary_gland MDA-MB-231 0.576271 -0.79518 0.0092836979 0.2772439 DataSet_03_443
HLA-DOA CAMTA1 knockout Embryo_kidney HEK293T 0.276243 -1.85599 1.449129e-03 0.05757132 DataSet_03_448
HLA-DOA CBX2 siRNA Mammary_gland MDA-MB-231 0.467085 -1.09824 7.415425e-02 1.992571e-01 DataSet_03_450
HLA-DOA CBX2 siRNA Mammary_gland MCF7 0.196516 -2.34728 1.244452e-01 0.2262581786 DataSet_03_451
HLA-DOA ZFP36L1 CRISPR Lung NCI-H1876 0.544563 -0.87683 8.331106e-01 0.993408056 DataSet_03_454
HLA-DOA PPARG siRNA Aortic_valve Valvular endothelial cell 7 2.80735 3.362359e-01 7.508584e-01 DataSet_03_456
HLA-DOA TXNIP shRNA Cord_Blood CD34+ cells 1.98947 0.992387 - - DataSet_03_461
HLA-DOA TXNIP shRNA Cord_blood ST3 2 1 6.398073e-01 0.7778693967 DataSet_03_462
HLA-DOA PARP1 knockout Embryo_kidney HEK293a 0.629163 -0.668495 4.666430e-02 1.109974e-01 DataSet_03_464
HLA-DOA SMARCA1 Cas13 Embryo_kidney HEK293T 0.393939 -1.34395 - - DataSet_03_466
HLA-DOA SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 2.24242 1.16506 - - DataSet_03_467
HLA-DOA SMARCA1 shRNA Embryo_kidney HEK293T 0.484848 -1.04439 - - DataSet_03_468
HLA-DOA WHSC1 siRNA Prostate PC3 0.660714 -0.597902 2.337475e-01 0.47833561 DataSet_03_471
Regulation Region
 
T(co)Fs that significantly regulate YBX1 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of HLA-DOA
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines