Gene Overview
| Target Gene: | Klhl23 |
| NCBI Official Symbol: | Klhl23 |
| Entrez ID: | 277396 |
| Ensembl ID: | ENSMUSG00000042155 |
| Gene Full Name: | kelch-like 23 |
| Strand: | + |
| Gene Locus: | 2|2 C2 |
| External Links: |
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Klhl23 Significantly Regulated by These T(co)Fs
T(co)Fs
that Activate Klhl23
T(co)Fs
that Repress Klhl23
The Intensity of the Gene Regulated by T(co)Fs:
Klhl23-T(co)F Pairs
| Target Gene |
T(co)F | Knock -Method |
Tissue Type | Biosample Name |
Fold Change |
Log2FC | P-value | Corrected _P |
Dataset ID |
|---|---|---|---|---|---|---|---|---|---|
| Klhl23 | Bcl6 | knockout | Bone_marrow | Myeloid cells | 0.457076 | -1.12949 | 0.00884402151645335 | 0.068343461353487 | DataSet_11_015 |
| Klhl23 | Cbx2 | knockout | Gonads | Embryonic gonads | 0.290821 | -1.7818 | 2.87018274122775e-11 | 9.75909184193521e-09 | DataSet_11_018 |
| Klhl23 | Cebpb | shRNA | Mammary_gland | 4T1 mammary tumor cells | 0.575042 | -0.798261 | 0.257414853047589 | 0.999984070881864 | DataSet_11_022 |
| Klhl23 | Dmrt1 | knockout | Testis | Juvenile testes | 0.623728 | -0.681012 | 0.0674468559894603 | 0.932139260123802 | DataSet_11_026 |
| Klhl23 | Elf5 | knockout | Mammary_gland | Mammary gland | 4.84466 | 2.2764 | 0.0122683228087846 | 0.22069148601648 | DataSet_11_035 |
| Klhl23 | Gata1 | siRNA | Bone_marrow | Bone marrow-derived mast cells | 2.89249 | 1.53231 | - | - | DataSet_11_046 |
| Klhl23 | Gata2 | knockout | Kidney | renal collecting duct cells | 0.49437 | -1.01634 | - | - | DataSet_11_047 |
| Klhl23 | Gfi1b | knockout | Bone_marrow | Ter119 positive erythroid cells | 0.665698 | -0.58706 | - | - | DataSet_11_054 |
| Klhl23 | Hsf4 | knockout | Eye | Lens | 0.563207 | -0.828262 | 0.404348308984025 | 0.987999303842427 | DataSet_11_058 |
| Klhl23 | Junb | shRNA | Tibialis_anterior_muscle | Tibialis anterior muscle | 1.66129 | 0.732302 | 0.0231512611166776 | 0.154733204518766 | DataSet_11_065 |
| Klhl23 | Lhx8 | knockout | Ovary | Ovary | 0.6482 | -0.62549 | 0.00668306124526824 | 0.0419659016918282 | DataSet_11_070 |
| Klhl23 | Mbd2 | knockout | Lymph | GFP+ BM leukemia cells | 2.66741 | 1.41544 | 5.84550753946447e-06 | 0.000218060560928116 | DataSet_11_076 |
| Klhl23 | Myb | shRNA | Hematopoietic | AML cells | 0.463401 | -1.10967 | 0.0122386304850696 | 0.0686243403327461 | DataSet_11_084 |
| Klhl23 | Nrf1 | knockdown | Liver | Liver | 1.87246 | 0.904936 | 0.0150802288309301 | 0.0564609303879033 | DataSet_11_096 |
| Klhl23 | Pax5 | knockout | Bone_marrow | B220+ cells | 1.92403 | 0.944135 | 0.0981611481880674 | 0.488122842140663 | DataSet_11_100 |
| Klhl23 | Pitx2 | knockout | Eye | Cornea | 4.75864 | 2.25055 | 0.319307131477487 | 0.680110606452178 | DataSet_11_103 |
| Klhl23 | Prdm2 | shRNA | Muscle | C2C12 | 0.662306 | -0.594431 | 0.0795888393495035 | 0.830744235679714 | DataSet_11_108 |
| Klhl23 | Runx1 | knockout | Lymph | ProB cells | 2.07808 | 1.05525 | 0.00760658585482806 | 0.0698022890090986 | DataSet_11_116 |
| Klhl23 | Runx2 | knockout | Humeri | Embryonic humeri | 1.92281 | 0.943219 | 0.0313372193666369 | 0.3473157968488 | DataSet_11_120 |
| Klhl23 | Smad1 | knockout | Lung | Lung left lobe | 0.647317 | -0.627457 | 0.113077858206805 | 0.542998753027287 | DataSet_11_126 |
| Klhl23 | Smad4 | siRNA | Brain | bEnd3 | 8.59179 | 3.10296 | - | - | DataSet_11_127 |
| Klhl23 | Smad4 | knockout | Aorta | Aortic arteries | 0.386845 | -1.37017 | 0.0181337779380802 | 0.208315830589822 | DataSet_11_128 |
| Klhl23 | Snai1 | knockout | Embryo | Embryonic stem cells (ESCs) | 0.660264 | -0.598885 | 0.00198885549686476 | 0.0652704380695804 | DataSet_11_131 |
| Klhl23 | Sohlh1 | knockout | Ovary | Ovary | 1.98309 | 0.98775 | 2.98433657384307e-07 | 2.28802767907742e-05 | DataSet_11_134 |
| Klhl23 | Sohlh2 | knockout | Ovary | Ovary | 1.71753 | 0.780333 | 5.33628037679129e-06 | 0.000143166337005434 | DataSet_11_135 |
| Klhl23 | Sox21 | knockout | Tooth | Incisor | 0.454544 | -1.13751 | - | - | DataSet_11_142 |
| Klhl23 | Stat3 | knockout | Lung | Lung typeII cells | 1.52996 | 0.613498 | 0.199573546579066 | 0.778749215320562 | DataSet_11_151 |
| Klhl23 | Stat6 | knockout | Bone_marrow | Bone marrow-derived macrophages | 1.62298 | 0.698645 | 0.0339240322000252 | 0.111597764490648 | DataSet_11_153 |
| Klhl23 | Tet2 | knockdown | Muscle | LSK | 0.565094 | -0.823436 | - | - | DataSet_11_163 |
| Klhl23 | Wt1 | knockout | Oviduct | Oviduct | 1.51335 | 0.597741 | 0.0255964105891707 | 0.719817031060092 | DataSet_11_180 |
| Klhl23 | Cpeb1 | siRNA | Neuron | Neuro-2a | 1.64874 | 0.721362 | - | - | DataSet_11_189 |
| Klhl23 | Siah2 | knockout | Heart | Primary isolated cells | 0.565894 | -0.821396 | 1.077723e-02 | 0.99981862 | DataSet_11_235 |
| Klhl23 | Mapk9 | knockout | Hip | Mouse Hip Cartilage | 0.620929 | -0.687499 | 2.032146e-02 | 5.040025e-02 | DataSet_11_236 |
| Klhl23 | Mapk9 | knockout | Knee | Mouse total knee | 1.51539 | 0.599684 | 4.387032e-02 | 0.205520453 | DataSet_11_237 |
| Klhl23 | Tet1 | shRNA | Embryo | ES cells | 1.63514 | 0.70941 | 2.078780e-02 | 0.27025367 | DataSet_11_213 |
| Klhl23 | Tet1 | shRNA | Embryo | ES cells | 1.63514 | 0.70941 | 2.078780e-02 | 0.27025367 | DataSet_11_214 |
| Klhl23 | Crebbp | knockout | Spleen | Germinal center B cells | 2.27768 | 1.18757 | 1.910591e-04 | 0.041856010 | DataSet_11_227 |
| Klhl23 | Ncl | siRNA | Embryo | ES cells | 0.6225 | -0.683854 | 1.414753e-01 | 0.5041526546 | DataSet_11_240 |
| Klhl23 | Dnmt3a | siRNA | Embryo | iPSC | 0.211148 | -2.24367 | - | - | DataSet_11_241 |
| Klhl23 | Twist1 | knockout | Bone_marrow | stromal cells | 0.287171 | -1.80002 | - | - | DataSet_11_244 |
| Klhl23 | Tet1 | shRNA | Muscle | MLL-ENL-ERtm | 0.456278 | -1.13201 | 1.536258e-05 | 3.556114e-04 | DataSet_11_249 |
| Klhl23 | Kmt2d | knockout | Skin | iBiP melanoma mouse model tumor cell | 3.88228 | 1.9569 | 1.496147e-04 | 2.224388e-03 | DataSet_11_250 |
| Klhl23 | Kdm2a | CRISPR | Embryo | ES cells | 0.562162 | -0.830942 | 0.3244563845 | 1.0000000 | DataSet_11_251 |
| Klhl23 | Zbp1 | siRNA | Bone_marrow | bone marrow-derived mesenchymal stem_progenitor cells | 0.234835 | -2.09028 | 3.112865e-03 | 0.034013435 | DataSet_11_252 |
| Klhl23 | Mecp2 | knockout | Adipose_tissue | inguinal adipose tissue | 2.24781 | 1.16852 | 4.264030e-03 | 0.1175959 | DataSet_11_254 |
| Klhl23 | Fubp1 | shRNA | Bone_marrow | BM cells | 0.482243 | -1.05217 | 8.720220e-03 | 0.267620437 | DataSet_11_262 |
| Klhl23 | Dux | knockout | Embryo | Embryo | 0.293586 | -1.76814 | 6.739939e-01 | 7.931315e-01 | DataSet_11_269 |
| Klhl23 | Myc | CRISPR | Skeletal_muscle | muscle stem cells | 0.308236 | -1.69789 | 5.520682e-02 | 0.70277930 | DataSet_11_272 |
| Klhl23 | Dux | knockout | Embryo | Embryo | 0.293586 | -1.76814 | 6.739949e-01 | 7.931451e-01 | DataSet_11_273 |
| Klhl23 | Myod1 | CRISPR | Skeletal_muscle | myoblast | 0.572327 | -0.805088 | 2.851618e-03 | 1.170551e-02 | DataSet_11_275 |
| Klhl23 | Dnmt1 | knockout | Cortex | mature Pvergic cortical interneurons | 1.63077 | 0.705553 | 4.910345e-02 | 0.6936949 | DataSet_11_283 |
| Klhl23 | Setd2 | knockout | Kidney | primary renal tubular epithelial (RTE) cells | 0.595687 | -0.747373 | - | - | DataSet_11_285 |
| Klhl23 | Pdx1 | CRISPR | Liver | Liver | 0.525253 | -0.928917 | 6.544363e-02 | 0.381964077 | DataSet_11_286 |
| Klhl23 | Fli1 | CRISPR | Lymph | CD8 T cells | 0.347368 | -1.52546 | 1.159877e-01 | 0.9999740103 | DataSet_11_288 |
| Klhl23 | Setd1a | shRNA | Eye | Retina | 1.5111 | 0.595598 | 3.099919e-02 | 0.1315118650 | DataSet_11_293 |
| Klhl23 | Mkl1 | knockout | Bone_marrow | Bone marrow differentiated macrophages | 1.55147 | 0.633636 | 8.390057e-02 | 0.4912687513 | DataSet_11_294 |
| Klhl23 | Foxp3 | CRISPR | Spleens_and_lymphnodes | CD4+ Th0 cells | 0.620766 | -0.68788 | - | - | DataSet_11_305 |
| Klhl23 | Myc | CRISPR | Skeletal_muscle | quiescent muscle stem cell | 2.34713 | 1.2309 | 4.200181e-01 | 0.80564524 | DataSet_11_310 |
| Klhl23 | Suz12 | knockout | Lung | Alveolar macrophage | 1.95897 | 0.970098 | 1.277095e-01 | 2.023993e-01 | DataSet_11_312 |
| Klhl23 | Irf7 | knockout | Bone_marrow | c-kit+ leukemic cells | 0.593714 | -0.75216 | - | - | DataSet_11_313 |
| Klhl23 | Arid1b | knockout | Bone_marrow | bone marrow leukemia cells | 0.493796 | -1.01801 | 1.575395e-01 | 0.5220475374 | DataSet_11_317 |
| Klhl23 | Kat7 | knockout | Thymic_lobes | Thymic epithelial cells | 1.68268 | 0.750761 | 1.191163e-02 | 9.255670e-02 | DataSet_11_320 |
| Klhl23 | Gata2 | knockout | Brain | Pituitary gland | 1.55323 | 0.635268 | 0.392539196 | 1.0000000 | DataSet_11_322 |
| Klhl23 | Setdb1 | shRNA | Neuron | NE-4C | 0.204972 | -2.2865 | - | - | DataSet_11_323 |
| Klhl23 | Kdm5b | siRNA | Embryo | ES cells | 0.212309 | -2.23576 | 0.0803971362 | 0.8933528 | DataSet_11_331 |
| Klhl23 | Ezh2 | shRNA | Brain | SVZ derived neural stem cells | 0.60215 | -0.731804 | 2.508451e-02 | 1.650825e-01 | DataSet_11_332 |
| Klhl23 | Dnmt1 | siRNA | Heart | embryonic cardiomyocytes | 0.419094 | -1.25466 | 4.406990e-03 | 0.014532025 | DataSet_11_340 |
| Klhl23 | Ezh2 | knockout | Small_intestinal_crypts | small intestinal crypts | 3.53584 | 1.82205 | 0.0570481556 | 0.1712697 | DataSet_11_341 |
| Klhl23 | Hnrnpk | siRNA | Embryo | ES cells | 0.279833 | -1.83736 | 1.009406e-05 | 0.002795507 | DataSet_11_342 |
| Klhl23 | Pcbp1 | shRNA | Thymus | Th1 | 1.71681 | 0.779734 | 2.161228e-02 | 0.12582104 | DataSet_11_343 |
Regulation Region
Expression Atlas of Klhl23