Gene Overview
Target Gene: LMNB2
NCBI Official Symbol: LMNB2
Entrez ID: 84823
Ensembl ID: ENSG00000176619
Gene Full Name: lamin B2
Strand: -
Gene Locus: 19p13.3
External Links:

LMNB2 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate LMNB2   
T(co)Fs that Repress LMNB2
The Intensity of the Gene Regulated by T(co)Fs:
LMNB2-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
LMNB2 FOXA1 siRNA Prostate LNCaP 0.55835 -0.84075 - - DataSet_01_104
LMNB2 FOXA1 shRNA Prostate 22RV1 0.4606 -1.11842 - - DataSet_01_105
LMNB2 ID1 siRNA Lung H1650 1.92376 0.94393 0.0055 0.32206 DataSet_01_118
LMNB2 ZNF665 siRNA Gastrointestinal_tissue GIST-T1 0.61399 -0.7037 0.00016 0.00555 DataSet_01_129
LMNB2 IKZF2 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 0.60907 -0.71533 0.25526 0.99993 DataSet_01_137
LMNB2 TFAP2C shRNA Mammary_gland MCF7 0.49873 -1.00367 0.00012 0.00043 DataSet_01_150
LMNB2 ELK1 siRNA Peripheral_blood CD4+ T cells 2.34273 1.22819 0.00064 0.00805 DataSet_01_162
LMNB2 GATA3 siRNA Peripheral_blood CD4+ T cells 302.984 8.2431 0.09542 0.42572 DataSet_01_163
LMNB2 JUN siRNA Peripheral_blood CD4+ T cells 1.67966 0.74817 0.01006 0.0685 DataSet_01_164
LMNB2 MAF siRNA Peripheral_blood CD4+ T cells 1.67867 0.74732 0.00823 0.09398 DataSet_01_165
LMNB2 NFATC3 siRNA Peripheral_blood CD4+ T cells 1.85939 0.89483 0.01025 0.09258 DataSet_01_166
LMNB2 ESRRG siRNA Placenta_tissue Trophoblast cells 1.58089 0.66074 0.00422 0.07694 DataSet_01_173
LMNB2 HSF1 shRNA Liver KYN2 0.53272 -0.90854 - - DataSet_01_178
LMNB2 TP63 shRNA Bladder UC14 0.66034 -0.59872 7.35021e-06 0.00025 DataSet_01_183
LMNB2 SPDEF siRNA Mammary_gland MCF7 0.48246 -1.05153 1e-04 0.04179 DataSet_01_189
LMNB2 AR siRNA Prostate R1-D567 0.48439 -1.04575 0.02345 0.29223 DataSet_01_192
LMNB2 GATA2 siRNA Prostate LNCaP 0.19015 -2.39481 2.27231e-08 1.10906e-05 DataSet_01_193
LMNB2 CREB1 shRNA Parotid_gland H3118 MEC 0.43505 -1.20075 0.06701 0.36283 DataSet_01_194
LMNB2 ATM shRNA Mammary_gland MCF10A 1.50167 0.58657 2.25668e-05 0.00028 DataSet_01_219
LMNB2 MYC shRNA Soft_tissue HT1080 0.42181 -1.24534 - - DataSet_01_237
LMNB2 STAT5 shRNA Haematopoietic_and_lymphoid_tissue K562 0.53938 -0.89062 5.89858e-05 0.00119 DataSet_01_239
LMNB2 TLX1 siRNA Haematopoietic_and_lymphoid_tissue ALLSIL 1.50323 0.58806 2.54949e-05 0.00813 DataSet_01_246
LMNB2 YBX1 shRNA Mammary_gland MDA 0.42154 -1.24625 0.00129 0.01115 DataSet_01_257
LMNB2 FOXO1 siRNA Umbilical_vein HUVEC 2.77558 1.47279 5.14836e-05 0.00498 DataSet_01_270
LMNB2 SALL4 shRNA Lung H661 1.70697 0.77144 0.10758 0.41813 DataSet_01_277
LMNB2 POSTN shRNA Brain GSC272 0.60234 -0.73134 0.26419 0.63061 DataSet_01_293
LMNB2 TFAP4 siRNA Brain BE(2)-C 0.11114 -3.1695 0.18286 0.51625 DataSet_01_295
LMNB2 MYCN siRNA Brain BE(2)-C 0.63077 -0.66482 0.81204 1 DataSet_01_296
LMNB2 TOX shRNA Haematopoietic_and_lymphoid_tissue CCRF-CEM 1.52505 0.60886 0.03026 0.5389 DataSet_01_331
LMNB2 HOXC6 siRNA Prostate LNCaP 1.65987 0.73107 0.06442 0.99927 DataSet_01_333
LMNB2 GATA3 siRNA Oral_cavity OEC-M1 2.47055 1.30483 0.01305 0.68576 DataSet_01_347
LMNB2 GTF2B siRNA Cervix HeLa 2.10863 1.0763 - - DataSet_01_362
LMNB2 RBM17 shRNA Liver HepG2 2.25109 1.17062 0.00376 0.26816 DataSet_02_100
LMNB2 SAFB2 shRNA Liver HepG2 0.61954 -0.69073 0.00295 0.02618 DataSet_02_102
LMNB2 U2AF2 shRNA Liver HepG2 0.64101 -0.64158 0.7064 0.80384 DataSet_02_105
LMNB2 ZNF622 shRNA Liver HepG2 0.59161 -0.75729 0.00086 0.00801 DataSet_02_108
LMNB2 BCLAF1 shRNA Liver HepG2 0.50349 -0.98996 0.00119 0.02531 DataSet_02_112
LMNB2 TARDBP shRNA Liver HepG2 0.49957 -1.00125 0.0014 0.01779 DataSet_02_116
LMNB2 SUB1 shRNA Liver HepG2 0.51842 -0.94779 0.01172 0.14014 DataSet_02_117
LMNB2 RBM34 shRNA Liver HepG2 0.61873 -0.69262 0.0289 0.40088 DataSet_02_121
LMNB2 HNRNPLL shRNA Liver HepG2 0.44531 -1.16712 0.00086 0.01222 DataSet_02_125
LMNB2 SNRNP70 shRNA Liver HepG2 0.27605 -1.857 0.00355 0.03668 DataSet_02_126
LMNB2 AGO2 shRNA Haematopoietic_and_lymphoid_tissue K562 1.50882 0.59342 0.01651 0.12009 DataSet_02_132
LMNB2 U2AF2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.61185 -0.70875 0.00621 0.05371 DataSet_02_170
LMNB2 ZFX siRNA Prostate C4-2B 0.63375 -0.65802 2.06987e-05 0.00084 DataSet_02_172
LMNB2 LMNB2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.50013 -0.99964 0.14882 1 DataSet_02_191
LMNB2 BCL6 siRNA Central_nervous_system U87 0.52716 -0.923688 2.13144961735186e-05 0.00471413442185655 DataSet_03_027
LMNB2 E2F7 siRNA Upper_aerodigestive_tract SCC25 0.425905 -1.2314 8.43814293346341e-09 2.05291944112315e-06 DataSet_03_063
LMNB2 ESR1 siRNA Uterus Endometrial stromal cells 1.53145 0.6149 - - DataSet_03_069
LMNB2 ESR1 siRNA Uterus Endometrial stromal cells 1.66173 0.732685 0.0127906627810425 1 DataSet_03_070
LMNB2 FOXA1 siRNA Mammary_gland MCF7 0.570214 -0.810424 9.06153999958565e-11 6.07650013693145e-09 DataSet_03_081
LMNB2 FOXA1 siRNA Mammary_gland MCF7 0.570214 -0.810424 9.06153999958565e-11 6.07650013693145e-09 DataSet_03_082
LMNB2 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 0.454576 -1.13741 - - DataSet_03_096
LMNB2 GATA2 siRNA Uterus Decidual stromal cells 0.590384 -0.760275 0.437898796960338 0.917045989227612 DataSet_03_100
LMNB2 GFP siRNA Upper_aerodigestive_tract SCC25 0.532845 -0.908211 3.09328453833243e-07 6.48067651075388e-05 DataSet_03_112
LMNB2 HNF4a siRNA Liver HepG2 0.293269 -1.76971 0.00103016145368655 0.245049156347868 DataSet_03_126
LMNB2 JARID1A siRNA Autonomic_ganglia SKNBE2 0.450008 -1.15198 0.0223096792299213 0.329941440192473 DataSet_03_135
LMNB2 JARID1A siRNA Brain NB1691 0.643469 -0.636058 0.00329939385833513 0.290091694307309 DataSet_03_136
LMNB2 Klf4 siRNA Skin Primary neonatal keratinocytes 1.64252 0.715912 0.0517566571705863 0.144283008628868 DataSet_03_147
LMNB2 MAFB siRNA Peripheral_blood Monocyte-derived M-CSF macrophages 1.57644 0.656667 0.0294052222651382 1 DataSet_03_155
LMNB2 MITF siRNA Skin MZ7 0.354139 -1.49761 1.38524575275499e-15 3.7842296178017e-13 DataSet_03_165
LMNB2 MITF siRNA Skin Ma-Mel-15 0.235577 -2.08573 0.000447734249334007 0.0319389398976272 DataSet_03_166
LMNB2 MITF siRNA Skin Ma-Mel-15 0.27666 -1.85381 1.64442962272249e-05 0.00155258409805079 DataSet_03_167
LMNB2 MITF siRNA Skin SK-MEL-5 0.488016 -1.035 8.17985996775207e-06 7.93930037542827e-05 DataSet_03_168
LMNB2 MYB siRNA Prostate VCaP 1.97383 0.981 3.47316792018962e-05 0.00749003842473986 DataSet_03_174
LMNB2 MYC siRNA Central_nervous_system DAOY M2.1 0.519921 -0.943637 1.20207919888136e-07 1.82233836907071e-06 DataSet_03_178
LMNB2 SOX11 siRNA Lung_fibroblast NHLF 0.235907 -2.08371 0.00488288216563638 0.304507242190339 DataSet_03_237
LMNB2 SOX11 siRNA Lung_fibroblast NHLF 0.177137 -2.49706 0.000712814403507549 0.144920899698915 DataSet_03_238
LMNB2 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.489968 -1.02924 - - DataSet_03_246
LMNB2 SP1 siRNA Mammary_gland MDA-MB-231 2.08439 1.05962 0.193851048333494 0.422480100429715 DataSet_03_250
LMNB2 SRF siRNA Prostate LNCaP 2.67967 1.42206 5.06056925484612e-05 0.000998966519723726 DataSet_03_254
LMNB2 STAT3 CRISPR Embryo hESC 2.02934 1.02101 0.0208822402695435 0.0847347628183179 DataSet_03_258
LMNB2 TFAP2C siRNA Mammary_gland MCF7 0.660846 -0.597614 0.101169058436244 0.449973531557828 DataSet_03_274
LMNB2 TP53 siRNA Foreskin Neonatal foreskin keratinocytes 0.615248 -0.70076 0.397824416564251 0.999791649573014 DataSet_03_278
LMNB2 TP63 siRNA Skin Primary neonatal keratinocytes 1.79949 0.847585 0.000288397811798307 0.00514380927277958 DataSet_03_281
LMNB2 TP63 siRNA Foreskin Neonatal foreskin keratinocytes 2.61768 1.38829 0.055026064753901 0.731077588222791 DataSet_03_282
LMNB2 TWIST1 siRNA Bone_marrow MSCs 0.444206 -1.1707 - - DataSet_03_283
LMNB2 MARK2 shRNA Haematopoietic_and_lymphoid_tissue K562 1.9475 0.96162 0.0105792730720325 0.0311115434258292 DataSet_04_012
LMNB2 NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 0.0509568 -4.29458 0.0126189273728176 0.0573848147299865 DataSet_04_014
LMNB2 NUP35 shRNA Haematopoietic_and_lymphoid_tissue K562 2.24787 1.16856 0.00578430616626696 0.0240631149871334 DataSet_04_015
LMNB2 NFX1 CRISPR Liver HepG2 0.601282 -0.733885 0.00283815990726918 0.0194121701513114 DataSet_04_032
LMNB2 ABT1 shRNA Liver HepG2 0.304288 -1.71649 1.71377972267471e-05 0.0013068406551314 DataSet_04_052
LMNB2 CALR shRNA Liver HepG2 0.39493 -1.34033 2.26473262817973e-05 0.0020570831170765 DataSet_04_053
LMNB2 DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.636414 -0.651962 0.0129621739746892 0.0448743745720446 DataSet_02_14
LMNB2 HDGF shRNA Haematopoietic_and_lymphoid_tissue K562 2.39749 1.26152 0.00110909733969939 0.00737978407124447 DataSet_04_059
LMNB2 EZH2 shRNA Colon SW480 0.471562 -1.08448 - - DataSet_03_298
LMNB2 PRMT1 shRNA Lung A549 0.511199 -0.968042 - - DataSet_03_342
LMNB2 INO80 siRNA Muscle RD 0.555298 -0.848665 - - DataSet_03_344
LMNB2 SKI CRISPR Blood HL60 0.520037 -0.943314 9.135588e-03 0.179858327 DataSet_03_351
LMNB2 TET1 CRISPR Mammary_gland Hs578T 0.594395 -0.750505 4.676442e-04 7.815598e-03 DataSet_03_355
LMNB2 CREBBP CRISPR Brain U5-NPC 1.79873 0.846979 0.2868999418 0.7490853 DataSet_03_356
LMNB2 PTPN14 CRISPR Brain U5-NPC 0.536829 -0.897465 7.321269e-02 0.29880336 DataSet_03_357
LMNB2 TP53 CRISPR Brain U5-NPC 1.84829 0.886191 2.240483e-01 3.568850e-01 DataSet_03_358
LMNB2 TP53 knockout Stomach SNU1 1.65571 0.727453 0.2483343896 0.9301241 DataSet_03_365
LMNB2 USP22 shRNA Liver PLC_PRF_5 cells 1.54394 0.626613 9.485337e-02 0.29049591 DataSet_03_368
LMNB2 DNMT3A knockout Embryo_kidney HEK293T 28.4834 4.83205 - - DataSet_03_369
LMNB2 ZFP36L1 siRNA Urinary_bladder J82 1.65681 0.728406 - - DataSet_03_371
LMNB2 E2F1 siRNA Nasopharynx HK1 0.202659 -2.30287 3.081624e-01 9.722824e-01 DataSet_03_373
LMNB2 ZNF213 siRNA Mammary_gland MCF7 14.4867 3.85666 4.955428e-01 7.227610e-01 DataSet_03_376
LMNB2 EZH2 CRISPR Ovary SKOV3 1.56759 0.648548 1.317209e-02 0.0894301565 DataSet_03_378
LMNB2 DDX5 shRNA Stomach HGC-27 0.468762 -1.09307 - - DataSet_03_379
LMNB2 DNMT1 siRNA Skin Human melanoma cells 0.561905 -0.831602 5.214514e-06 6.820016e-05 DataSet_03_382
LMNB2 YY1 shRNA Brain GSC1517 0.552041 -0.857154 - - DataSet_03_384
LMNB2 ILF2 siRNA Stomach SGC-7901 2.36538 1.24207 0.0264635066 0.09875280 DataSet_03_393
LMNB2 RELA CRISPR Brain T30 0.632328 -0.661255 0.3838658709 0.8400824 DataSet_03_399
LMNB2 CDK7 shRNA Bone_marrow D458 0.622878 -0.682979 1.193184e-01 0.43432051 DataSet_03_404
LMNB2 E2F6 shRNA Liver HuH7 1.52053 0.604573 - - DataSet_03_412
LMNB2 E2F2 siRNA Prostate LNCaP 0.403518 -1.3093 8.823428e-05 3.294937e-03 DataSet_03_414
LMNB2 NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 3.11384 1.63869 6.262796e-04 0.009095545 DataSet_03_418
LMNB2 MAEL CRISPR Liver Alexander cells 1.90714 0.931411 - - DataSet_03_423
LMNB2 FOXP3 CRISPR Peripheral_blood Naive Treg 3.28022 1.71379 7.712106e-04 0.085569154 DataSet_03_427
LMNB2 USP7 shRNA Skin xenograft cells 0.442438 -1.17645 0.26624378 0.4348960 DataSet_03_431
LMNB2 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 0.604306 -0.726649 3.652522e-01 0.90558273 DataSet_03_439
LMNB2 SETDB1 shRNA Colon HCT116 0.426775 -1.22845 - - DataSet_03_440
LMNB2 PURA siRNA Cervix HeLa 0.543911 -0.878556 8.621872e-04 0.043716294 DataSet_03_444
LMNB2 IRF2 shRNA Cord_Blood CD34+ cells 1.58533 0.664786 - - DataSet_03_460
LMNB2 TXNIP shRNA Cord_Blood CD34+ cells 1.84048 0.880079 - - DataSet_03_461
LMNB2 TXNIP shRNA Cord_blood ST3 1.55151 0.633678 1.342894e-01 0.4209351573 DataSet_03_462
LMNB2 PARP1 knockout Embryo_kidney HEK293a 1.61711 0.69342 2.153062e-04 1.275008e-03 DataSet_03_464
LMNB2 SMARCA1 Cas13 Embryo_kidney HEK293T 0.417984 -1.25848 - - DataSet_03_466
LMNB2 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 1.91868 0.940116 - - DataSet_03_467
Regulation Region
 
T(co)Fs that significantly regulate SPDEF by the evidences of both expression and ChIP-seq/motif
Expression Atlas of LMNB2
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines