Gene Overview
Target Gene: LRP1B
NCBI Official Symbol: LRP1B
Entrez ID: 53353
Ensembl ID: ENSG00000168702
Gene Full Name: LDL receptor related protein 1B
Strand: -
Gene Locus: 2q22.1-q22.2
External Links:

LRP1B Significantly Regulated by These T(co)Fs

T(co)Fs that Activate LRP1B   
T(co)Fs that Repress LRP1B
The Intensity of the Gene Regulated by T(co)Fs:
LRP1B-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
LRP1B SPDEF shRNA Mammary_gland MCF7 5.42606 2.43991 0.74737 0.99999 DataSet_01_107
LRP1B ID1 siRNA Lung A549 5.69169 2.50886 0.34853 0.57369 DataSet_01_117
LRP1B ZIC2 siRNA Pancreas PANC1 1.71809 0.7808 - - DataSet_01_121
LRP1B FOXM1 siRNA Central_nervous_system U87 0.10985 -3.18638 - - DataSet_01_122
LRP1B ZNF91 siRNA Gastrointestinal_tissue GIST-T1 0.65646 -0.60722 0.00241 0.03105 DataSet_01_123
LRP1B ZNF43 siRNA Gastrointestinal_tissue GIST-T1 0.59491 -0.74925 0.00059 0.01603 DataSet_01_125
LRP1B ZNF85 siRNA Gastrointestinal_tissue GIST-T1 0.62208 -0.68482 0.0011 0.01075 DataSet_01_126
LRP1B ZNF254 siRNA Gastrointestinal_tissue GIST-T1 0.634 -0.65745 0.00145 0.01649 DataSet_01_127
LRP1B ZNF708 siRNA Gastrointestinal_tissue GIST-T1 0.55562 -0.84783 0.00024 0.00832 DataSet_01_130
LRP1B ID1 shRNA Neuroepithelium GSC8 0.41389 -1.27268 5.67931e-11 4.14631e-10 DataSet_01_134
LRP1B POLR3A siRNA Mammary_gland MCF7 0.6184 -0.69338 - - DataSet_01_139
LRP1B NR3C1 siRNA Uterus Endometrial stromal cells 1.55833 0.64 0.35893 0.99972 DataSet_01_141
LRP1B GATA3 siRNA Peripheral_blood CD4+ T cells 1.95937 0.97039 0.13261 0.46099 DataSet_01_163
LRP1B TCF4 siRNA Autonomic_ganglia SH-SY5Y 0.65045 -0.62049 0.20705 0.39525 DataSet_01_185
LRP1B CREB1 shRNA Parotid_gland HSY 0.56598 -0.82119 0.15725 0.81834 DataSet_01_195
LRP1B TP63 siRNA Immortalized_keratinocyte HaCaT RG 0.61765 -0.69515 - - DataSet_01_196
LRP1B TP63 siRNA Head_and_neck SCC-1 4.5 2.16993 - - DataSet_01_198
LRP1B TP63 siRNA Immortalized_keratinocyte HaCaT 4.26316 2.09192 - - DataSet_01_200
LRP1B TP63 siRNA Head_and_neck SCC-6 0.12458 -3.00487 - - DataSet_01_202
LRP1B XBP1 shRNA Mammary_gland MDA-MB-231 0.52429 -0.93157 0.00609 0.05041 DataSet_01_204
LRP1B FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 10.9583 3.45395 - - DataSet_01_208
LRP1B FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 0.24521 -2.0279 - - DataSet_01_209
LRP1B FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.34514 -1.53476 - - DataSet_01_210
LRP1B SNAI2 shRNA Skin Primary human keratinocytes 5.94599 2.57192 0.17374 0.30411 DataSet_01_225
LRP1B ESR2 siRNA Mammary_gland BT549 1.64718 0.72 1.15913e-05 0.00031 DataSet_01_229
LRP1B SIX4 siRNA Ovary PEO1 0.62815 -0.67082 0.11086 0.32332 DataSet_01_269
LRP1B AR shRNA Prostate CWR22Pc 0.6439 -0.63508 0.3734 0.60288 DataSet_01_278
LRP1B STAT5 shRNA Prostate CWR22Pc 1.97435 0.98138 0.0479 0.14579 DataSet_01_279
LRP1B ESRRA shRNA Embryo_kidney 293T 1.65881 0.73015 0.03617 0.64205 DataSet_01_280
LRP1B ZIC5 siRNA Skin A375 2.174 1.12036 - - DataSet_01_284
LRP1B SP3 siRNA Haematopoietic_and_lymphoid_tissue JURKAT 4.14608 2.05175 0.14443 0.89131 DataSet_01_290
LRP1B POSTN shRNA Brain GSC272 3.16917 1.66411 0.07605 0.54319 DataSet_01_293
LRP1B TFAP4 siRNA Brain BE(2)-C 0.29863 -1.74355 0.45254 0.51643 DataSet_01_295
LRP1B PTEN shRNA Lung HCC827 0.344 -1.53952 0.36666 0.76234 DataSet_01_302
LRP1B PTEN shRNA Mammary_gland SKBR3 9.9349 3.31251 0.01085 0.45372 DataSet_01_303
LRP1B SOX9 siRNA Prostate VCaP 15.1667 3.92283 0.01983 0.9316 DataSet_01_308
LRP1B SOX9 siRNA Prostate VCaP 15.1667 3.92283 0.01983 0.9316 DataSet_01_309
LRP1B MYC siRNA Colon HCT116 2.99493 1.58252 0.00123 0.00361 DataSet_01_324
LRP1B HOXC6 siRNA Prostate LNCaP 8.74194 3.12795 0.15708 0.99927 DataSet_01_333
LRP1B ZNF24 siRNA Embryo_kidney HEK293 1.95071 0.964 - - DataSet_01_353
LRP1B ETV4 shRNA Prostate PC3 2.40298 1.26482 - - DataSet_01_356
LRP1B HDGF shRNA Liver HepG2 0.33333 -1.58496 0.03494 0.14682 DataSet_02_104
LRP1B RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 0.1 -3.32193 0.01748 0.2135 DataSet_02_171
LRP1B RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 0.22222 -2.16993 0.15068 1 DataSet_02_190
LRP1B AR siRNA Prostate LNCaP 3.08823 1.62678 0.150149210087633 1 DataSet_03_005
LRP1B ARID1A siRNA Mammary_gland MDA-MB-157 0.452189 -1.145 - - DataSet_03_014
LRP1B ARID2 CRISPR Liver JHH4 2.35851 1.23787 0.412633288182857 1 DataSet_03_015
LRP1B ASCL1 siRNA Lung DMS79 6.75 2.75489 0.460860254065571 0.904584974080861 DataSet_03_016
LRP1B BCL6 siRNA Lymph Pfeiffer DLBCL 2.05628 1.04003 0.405533149526713 0.799011466283089 DataSet_03_026
LRP1B CEBPB siRNA Embryo hESC 0.330977 -1.5952 0.0951948543413473 0.456677097792642 DataSet_03_049
LRP1B GATA4 siRNA Stomach AGS 8.20601 3.03668 0.0290639987768962 0.59353123566848 DataSet_03_105
LRP1B GATA4 siRNA Stomach YCC3 0.38647 -1.37157 0.220156230726314 0.747137310198768 DataSet_03_107
LRP1B GATA6 siRNA Stomach AGS 27.4483 4.77864 0.000308638094223899 0.0839173932035614 DataSet_03_108
LRP1B GATA6 siRNA Stomach KatoIII 3.25588 1.70305 0.354498867392744 0.804935826086806 DataSet_03_109
LRP1B GFP siRNA Mammary_gland BT-20 cells 0.6 -0.736966 0.0868702831141834 0.582206573414568 DataSet_03_111
LRP1B HNF4a siRNA Liver HepG2 0.614035 -0.703607 0.275865153036746 0.842100350861395 DataSet_03_126
LRP1B KDM3A siRNA Mammary_gland MCF7 1.71555 0.778674 0.000265193906551768 0.00794528272358121 DataSet_03_146
LRP1B KLF5 siRNA Stomach AGS 1.5743 0.654712 0.449943162690784 0.822710545545022 DataSet_03_149
LRP1B KLF5 siRNA Stomach KatoIII 1.6136 0.690286 0.725124782471856 0.91776787390871 DataSet_03_150
LRP1B KLF5 siRNA Stomach YCC3 0.188708 -2.40578 0.0455250870386261 0.321751227095773 DataSet_03_151
LRP1B MEF2D shRNA Liver HuH7 1.65699 0.728564 - - DataSet_03_162
LRP1B MEF2D siRNA Liver HuH7 1.51704 0.601255 - - DataSet_03_163
LRP1B MYB siRNA Cord_Blood CD34+ progenitor cells 6.19833 2.63188 - - DataSet_03_170
LRP1B MYC siRNA Colon HT29 0.216004 -2.21087 - - DataSet_03_177
LRP1B MYCN CRISPR Neuroblastoma CHP-134 0.561486 -0.832677 7.54606658209238e-07 0.000110035370887965 DataSet_03_183
LRP1B MYCN CRISPR Neuroblastoma CHP-134 0.561486 -0.832677 7.54606658209238e-07 0.000110035370887965 DataSet_03_184
LRP1B PHB shRNA Embryo Embryonic stem cells (ESCs) 3.7667 1.9133 0.0172359263254345 0.0484874098147656 DataSet_03_211
LRP1B PRRX1 CRISPR Neuroblastoma 691-MES 3.41332 1.77118 0.152564875983003 0.89189998148014 DataSet_03_217
LRP1B STAT1 knockout Liver Huh-7.5 0.392908 -1.34774 1.11600940515639e-05 0.00377890489015563 DataSet_03_257
LRP1B STAT3 CRISPR Embryo hESC 3.67068 1.87605 0.0507109160323277 0.125559443133082 DataSet_03_258
LRP1B STAT6 siRNA Umbilical_vein HUVEC 0.0941176 -3.40939 0.182777524233064 0.839993057569398 DataSet_03_264
LRP1B TFAP2C siRNA Mammary_gland MCF7 0.459578 -1.12162 0.0723002421730068 0.411806606829616 DataSet_03_274
LRP1B ZNF746 siRNA Colon HCT116 3.09728 1.631 - - DataSet_03_293
LRP1B SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.0526316 -4.24793 0.412062551388495 0.78457520785049 DataSet_02_49
LRP1B CNOT3 shRNA Lung A549 0.350664 -1.51184 4.256357e-01 0.9098332 DataSet_03_340
LRP1B ZNF598 knockout Cervix HeLa 0.642933 -0.637259 1.178212e-01 1.0000000 DataSet_03_299
LRP1B ELF3 knockdown Bile_duct HBDEC2 0.259235 -1.94767 2.500252e-01 3.954868e-01 DataSet_03_305
LRP1B AEBP1 siRNA Central_nervous_system U87MG 0.426921 -1.22796 3.765182e-02 0.9964883 DataSet_03_338
LRP1B EZH2 knockdown Colon HCT116 5.89502 2.5595 0.225010900 0.8897583 DataSet_03_334
LRP1B ESR1 siRNA Mammary_gland MCF7 1.54879 0.631144 3.164994e-03 0.0346170494 DataSet_03_352
LRP1B PTPN14 CRISPR Brain U5-NPC 1.78084 0.832561 5.747036e-02 0.28219688 DataSet_03_357
LRP1B NCOA3 siRNA Mammary_gland MDA-MB-231 0.208754 -2.26013 1.626557e-01 0.6692697 DataSet_03_361
LRP1B ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 3.25865 1.70428 1.672041e-01 2.556382e-01 DataSet_03_362
LRP1B MYC siRNA Peripheral_blood T lymphocyte 4.38295 2.1319 8.354439e-01 0.931437724 DataSet_03_363
LRP1B USP22 shRNA Liver PLC_PRF_5 cells 2.83333 1.5025 1.068000e-01 0.30716875 DataSet_03_368
LRP1B DNMT3A knockout Embryo_kidney HEK293T 1.5858 0.665214 - - DataSet_03_369
LRP1B ZFP36L1 siRNA Urinary_bladder J82 19 4.24793 - - DataSet_03_371
LRP1B EZH2 CRISPR Ovary SKOV3 2.16667 1.11548 6.181136e-01 0.7592613766 DataSet_03_378
LRP1B TCF19 CRISPR Oral_squamous CAL27 1.69123 0.758076 6.048653e-01 0.8173597648 DataSet_03_383
LRP1B NFKBIA shRNA Bone_marrow U2OS 0.0154953 -6.01202 8.228708e-01 0.92598452 DataSet_03_389
LRP1B ILF2 siRNA Stomach SGC-7901 0.642857 -0.63743 0.4457946010 0.65928663 DataSet_03_393
LRP1B EHF shRNA Stomach MKN7 0.000160612 -12.6041 - - DataSet_03_402
LRP1B CDK7 shRNA Bone_marrow D458 0.379747 -1.39689 2.630976e-02 0.25043046 DataSet_03_404
LRP1B TFAP2A knockout Embryo H9 3.26412 1.70669 2.765255e-04 0.01906004 DataSet_03_405
LRP1B MAP3K7 shRNA Prostate LNCaP 0.594828 -0.749457 1.551045e-02 1.046781e-01 DataSet_03_408
LRP1B SIRT1 siRNA Pancreas PANC1 3.5 1.80736 5.330279e-01 0.680599293 DataSet_03_410
LRP1B E2F2 siRNA Prostate LNCaP 6 2.58496 6.002633e-02 2.112562e-01 DataSet_03_414
LRP1B ZKSCAN3 CRISPR Colon HCT116 0.26073 -1.93937 4.159605e-03 0.151578837 DataSet_03_415
LRP1B RUNX2 shRNA Cord_blood Natural Killer Cell 4.5 2.16992 6.117461e-01 0.870584911 DataSet_03_416
LRP1B DNMT3B shRNA Embryo 2102Ep 0.628059 -0.671028 1.297779e-06 5.395515e-04 DataSet_03_417
LRP1B FOXK2 shRNA Ovary OVCAR-5 0.176471 -2.5025 1.516749e-01 0.37012049 DataSet_03_419
LRP1B FOXP3 CRISPR Peripheral_blood Naive Treg 2 1 4.049342e-01 0.717248758 DataSet_03_427
LRP1B LHX2 shRNA Bone_marrow ES-derived RPE cells 0.4125 -1.27753 5.466293e-03 5.262415e-01 DataSet_03_428
LRP1B USP7 shRNA Skin xenograft cells 0.397059 -1.33258 0.22616732 0.4348960 DataSet_03_431
LRP1B POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 6 2.58496 1.754611e-01 0.539101373 DataSet_03_434
LRP1B PURA siRNA Cervix HeLa 1.58984 0.668885 1.684314e-02 0.117688183 DataSet_03_444
LRP1B CAMTA1 knockout Embryo_kidney HEK293T 0.598131 -0.741467 1.210697e-02 0.11693143 DataSet_03_448
LRP1B CBX2 siRNA Mammary_gland MDA-MB-231 0.50926 -0.973526 7.986967e-01 8.988544e-01 DataSet_03_450
LRP1B CBX2 siRNA Mammary_gland MCF7 1.88124 0.91168 2.523689e-04 0.0023454283 DataSet_03_451
LRP1B SMARCA2 shRNA Lung HCC2302 2.7691 1.46942 1.703307e-07 5.420287e-07 DataSet_03_455
LRP1B ARID1A shRNA Bile_duct MMNK1 0.40495 -1.30418 1.206673e-01 0.375857531 DataSet_03_458
LRP1B PARP1 knockout Embryo_kidney HEK293a 3.92 1.97085 1.611683e-05 1.434970e-04 DataSet_03_464
LRP1B SMARCA1 Cas13 Embryo_kidney HEK293T 0.242472 -2.04411 - - DataSet_03_466
LRP1B SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 1.75753 0.813547 - - DataSet_03_467
LRP1B LIN28A siRNA Mammary_gland MCF7M 0.664752 -0.589111 3.331958e-02 0.2810280 DataSet_03_469
LRP1B LIN28A siRNA Mammary_gland MCF7M 0.664752 -0.589111 3.331958e-02 0.2810280 DataSet_03_470
LRP1B WHSC1 siRNA Prostate PC3 0.5 -1 9.069113e-01 0.96129735 DataSet_03_471
LRP1B EZH2 siRNA Umbilical_vein HUVEC 1.8 0.847997 7.347320e-02 0.288985108 DataSet_03_473
LRP1B EZH2 siRNA Prostate LNCaP 4 2 6.817555e-01 1.0000000 DataSet_03_475
LRP1B HMGB2 knockdown Umbilical_vein HUVEC 1.53846 0.621488 1.963148e-01 0.34091656 DataSet_03_476
Regulation Region
 
T(co)Fs that significantly regulate HOXC6 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of LRP1B
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines