Gene Overview
Target Gene: NR1D2
NCBI Official Symbol: NR1D2
Entrez ID: 9975
Ensembl ID: ENSG00000174738
Gene Full Name: nuclear receptor subfamily 1 group D member 2
Strand: +
Gene Locus: 3p24.2
External Links:

NR1D2 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate NR1D2   
T(co)Fs that Repress NR1D2
The Intensity of the Gene Regulated by T(co)Fs:
NR1D2-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
NR1D2 FOXO1 shRNA Bone EWS-FLI1 0.63495 -0.65528 7.2501e-06 0.00612 DataSet_01_106
NR1D2 ESR1 siRNA Mammary_gland MCF7 1.64727 0.72008 0.00244 0.07826 DataSet_01_111
NR1D2 BRD4 shRNA Embryo_kidney HEK293 0.52568 -0.92775 - - DataSet_01_119
NR1D2 ZIC2 siRNA Pancreas PANC1 3.41412 1.77151 - - DataSet_01_121
NR1D2 ZNF85 siRNA Gastrointestinal_tissue GIST-T1 0.54936 -0.86416 3.10605e-05 0.00182 DataSet_01_126
NR1D2 ZNF431 siRNA Gastrointestinal_tissue GIST-T1 0.52345 -0.93388 1.64611e-05 0.00069 DataSet_01_128
NR1D2 IKZF2 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 1.98339 0.98797 0.04413 0.63275 DataSet_01_137
NR1D2 MYCN siRNA Autonomic_ganglia SKNBE2 0.53072 -0.91397 0.00198 0.07257 DataSet_01_160
NR1D2 ELK1 siRNA Peripheral_blood CD4+ T cells 0.48209 -1.05262 0.07508 0.20059 DataSet_01_162
NR1D2 GATA3 siRNA Peripheral_blood CD4+ T cells 1.98922 0.9922 0.02631 0.2682 DataSet_01_163
NR1D2 JUN siRNA Peripheral_blood CD4+ T cells 0.53256 -0.90899 0.13182 0.34105 DataSet_01_164
NR1D2 MAF siRNA Peripheral_blood CD4+ T cells 0.50402 -0.98846 0.09615 0.38256 DataSet_01_165
NR1D2 NFATC3 siRNA Peripheral_blood CD4+ T cells 0.44053 -1.18268 0.04478 0.221 DataSet_01_166
NR1D2 NFKB1 siRNA Peripheral_blood CD4+ T cells 1.66612 0.73649 0.06863 0.65882 DataSet_01_167
NR1D2 STAT3 siRNA Peripheral_blood CD4+ T cells 0.51424 -0.95948 0.10353 0.99183 DataSet_01_168
NR1D2 HSF1 shRNA Liver KYN2 1.70752 0.7719 - - DataSet_01_178
NR1D2 GABPA shRNA Prostate C4-2B 2312.55 11.1753 0.2361 0.43934 DataSet_01_190
NR1D2 GABPA shRNA Prostate LNCaP 1491.37 10.5424 0.46548 0.7048 DataSet_01_191
NR1D2 TP63 siRNA Head_and_neck SCC-1 0.6466 -0.62905 - - DataSet_01_199
NR1D2 XBP1 shRNA Mammary_gland T47D 2.24779 1.1685 5.39367e-06 0.00029 DataSet_01_203
NR1D2 FOXP1 siRNA Prostate LNCaP 0.5747 -0.79912 0.00295 0.18346 DataSet_01_234
NR1D2 SMAD3 siRNA Liver Hep3B 1.5149 0.59922 - - DataSet_01_249
NR1D2 YBX1 shRNA Mammary_gland MDA 2.01221 1.00878 0.00209 0.01579 DataSet_01_257
NR1D2 SIX4 siRNA Ovary PEO1 0.60809 -0.71765 0.00141 0.01842 DataSet_01_269
NR1D2 SALL4 shRNA Lung H661 0.44432 -1.17033 0.01596 0.15353 DataSet_01_277
NR1D2 TFAP4 siRNA Brain BE(2)-C 0.33101 -1.59506 0.49607 0.53009 DataSet_01_295
NR1D2 MYCN siRNA Brain BE(2)-C 0.50326 -0.99061 0.74891 1 DataSet_01_296
NR1D2 PTEN shRNA Skin A431 1.56926 0.65008 0.00782 0.08864 DataSet_01_301
NR1D2 ETV5 siRNA Soft_tissue hADSC 0.53219 -0.90998 0.00029 0.00967 DataSet_01_304
NR1D2 ELK3 shRNA Mammary_gland MDA-MB-231 0.66306 -0.59278 0.00025 0.00115 DataSet_01_318
NR1D2 FOXO1 shRNA Haematopoietic_and_lymphoid_tissue 018Z 0.6446 -0.63352 0.02366 0.93203 DataSet_01_322
NR1D2 MYC siRNA Colon HCT116 2.09272 1.06538 1.34196e-09 4.37021e-08 DataSet_01_324
NR1D2 SOX17 siRNA Umbilical_vein HUVEC 1.67681 0.74572 - - DataSet_01_360
NR1D2 TAF15 shRNA Liver HepG2 2.95975 1.56547 8.88026e-05 0.01075 DataSet_02_106
NR1D2 U2AF2 shRNA Liver HepG2 0.62055 -0.68839 0.3081 0.45486 DataSet_02_113
NR1D2 TARDBP shRNA Liver HepG2 1.83958 0.87938 0.00294 0.0218 DataSet_02_116
NR1D2 SNRNP70 shRNA Liver HepG2 2.8375 1.50462 0.00038 0.03074 DataSet_02_126
NR1D2 SRSF3 shRNA Liver HepG2 2.525 1.33628 0.00037 0.06113 DataSet_02_127
NR1D2 TARDBP shRNA Haematopoietic_and_lymphoid_tissue K562 0.59534 -0.74821 0.36876 0.64557 DataSet_02_129
NR1D2 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.4294 -1.2196 0.00131 0.02779 DataSet_02_131
NR1D2 TAF15 shRNA Haematopoietic_and_lymphoid_tissue K562 1.54545 0.62803 0.16397 0.39491 DataSet_02_140
NR1D2 RBM39 shRNA Haematopoietic_and_lymphoid_tissue K562 1.57438 0.65478 0.02651 0.2379 DataSet_02_151
NR1D2 ILF2 shRNA Haematopoietic_and_lymphoid_tissue K562 2.19281 1.13278 0.00158 0.23369 DataSet_02_152
NR1D2 SSB shRNA Haematopoietic_and_lymphoid_tissue K562 1.5545 0.63645 0.00819 0.20269 DataSet_02_164
NR1D2 ATF3 siRNA Haematopoietic_and_lymphoid_tissue K562 0.58808 -0.76593 0.1008 1 DataSet_02_180
NR1D2 RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 0.66019 -0.59904 0.47914 1 DataSet_02_190
NR1D2 BRCA1 siRNA Haematopoietic_and_lymphoid_tissue K562 1.67662 0.74555 0.2361 1 DataSet_02_202
NR1D2 ATOH8 siRNA Umbilical_vein HUVEC 1.65219 0.724378 0.194774471925879 0.894358872581733 DataSet_03_019
NR1D2 ATR siRNA Mammary_gland MCF7 0.60669 -0.72097 0.112045877292621 0.999819450785634 DataSet_03_020
NR1D2 BCL6 siRNA Mammary_gland MCF7 0.444205 -1.1707 0.0223049773109251 0.989541443114508 DataSet_03_024
NR1D2 CEBPA siRNA Mammary_gland MCF7 1.50674 0.591427 0.178739653055146 0.999962793175751 DataSet_03_047
NR1D2 CEBPD siRNA Mammary_gland MCF7 0.477565 -1.06623 0.0321428010520903 0.999848455332859 DataSet_03_050
NR1D2 FOS siRNA Mammary_gland MCF7 0.574396 -0.799883 0.0840340134815621 0.999966427400474 DataSet_03_079
NR1D2 FOXO1 shRNA Haematopoietic_and_lymphoid_tissue BL41 0.38175 -1.3893 0.000372314476390705 0.101394364180519 DataSet_03_094
NR1D2 FOXO1 shRNA Haematopoietic_and_lymphoid_tissue Namalwa 0.539582 -0.890086 7.15984467742117e-05 0.0218450133842525 DataSet_03_095
NR1D2 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 1.60802 0.685282 - - DataSet_03_096
NR1D2 FOXP1 siRNA Mammary_gland MCF7 0.638913 -0.646309 0.146845136227283 0.999975993110711 DataSet_03_099
NR1D2 GATA3 siRNA Mammary_gland MCF7 0.453901 -1.13955 0.0248498381311873 0.999831535534034 DataSet_03_102
NR1D2 GATA3 siRNA Mammary_gland MCF7 1.6872 0.754635 0.0887080392729468 0.229154728704121 DataSet_03_103
NR1D2 HDAC3 siRNA Mammary_gland MCF7 0.623733 -0.681001 0.129546476886611 0.99997791025972 DataSet_03_114
NR1D2 HDAC5 siRNA Mammary_gland MCF7 1.60058 0.678592 0.130680983421452 0.999966625300244 DataSet_03_115
NR1D2 HIF1A siRNA Mammary_gland MCF7 0.656708 -0.606677 0.169282768608637 0.999966843283762 DataSet_03_119
NR1D2 HNF4a siRNA Liver HepG2 1.7383 0.79768 0.0343088171338987 0.604030434987461 DataSet_03_126
NR1D2 ID1 siRNA Mammary_gland MCF7 0.625806 -0.676213 0.131812129258727 0.999926480273844 DataSet_03_133
NR1D2 JUN siRNA Mammary_gland MCF7 0.541781 -0.884219 0.125082098066381 0.999857657786768 DataSet_03_142
NR1D2 JUND siRNA Mammary_gland MCF7 0.619564 -0.690675 0.0618026156974295 0.999848956486105 DataSet_03_145
NR1D2 Klf4 siRNA Skin Primary neonatal keratinocytes 0.650818 -0.619675 0.0211073571555199 0.0762944114843572 DataSet_03_147
NR1D2 KLF5 siRNA Colon SW480 0.623159 -0.682328 0.000268125116132825 0.0353013527900478 DataSet_03_148
NR1D2 MAF siRNA Lymph Lymphatic endothelial cells 1.70621 0.770797 0.0292969195447805 0.816720674716982 DataSet_03_154
NR1D2 MAPK1 siRNA Mammary_gland MCF7 0.642992 -0.637127 0.107850437279194 0.999829384224364 DataSet_03_156
NR1D2 MAPK14 siRNA Mammary_gland MCF7 0.602296 -0.731455 0.151779296333077 0.999824418484635 DataSet_03_157
NR1D2 MAX siRNA Mammary_gland MCF7 0.531269 -0.912486 0.0557766564036164 0.999907009675999 DataSet_03_158
NR1D2 MCM2 siRNA Mammary_gland MCF7 0.417095 -1.26155 0.0163550232518344 0.999925560383539 DataSet_03_161
NR1D2 MITF siRNA Skin SK-MEL-5 0.49153 -1.02465 8.82891116293607e-06 8.44770208225827e-05 DataSet_03_168
NR1D2 MTA2 siRNA Stomach SGC-7901 0.288494 -1.79339 - - DataSet_03_169
NR1D2 MYB siRNA Cord_Blood CD34+ progenitor cells 1.5296 0.613157 - - DataSet_03_170
NR1D2 MYCN CRISPR Neuroblastoma CHP-134 0.657875 -0.604115 2.31380536384035e-05 0.00097666942199998 DataSet_03_183
NR1D2 MYCN CRISPR Neuroblastoma CHP-134 0.657875 -0.604115 2.31380536384035e-05 0.00097666942199998 DataSet_03_184
NR1D2 MYCN siRNA Autonomic_ganglia SKNBE2 0.530724 -0.913967 0.00188704038633802 0.0738168833936639 DataSet_03_185
NR1D2 NCOR2 siRNA Mammary_gland MCF7 0.523902 -0.93263 0.0518538025018062 0.999834929103349 DataSet_03_193
NR1D2 NFKB1 siRNA Central_nervous_system U251 0.597016 -0.744159 0.0091109289715259 0.048394620151294 DataSet_03_197
NR1D2 NMI siRNA Mammary_gland MCF7 0.63077 -0.664814 0.137360269539904 0.724212837656518 DataSet_03_199
NR1D2 RBL2 siRNA Mammary_gland MCF7 0.613753 -0.704271 0.119058950035108 0.999927471951507 DataSet_03_220
NR1D2 RELB siRNA Pancreas MIA PaCa-2 0.442563 -1.17604 0.00478056833620561 0.0623155580848208 DataSet_03_225
NR1D2 RELB siRNA Immortalized_keratinocyte HaCaT 1.57701 0.657194 0.0037380706769639 0.0249141092620146 DataSet_03_227
NR1D2 SMAD7 siRNA Mammary_gland MCF7 0.525608 -0.927942 0.0527406433132079 0.99858912864726 DataSet_03_234
NR1D2 SOX11 siRNA Lung_fibroblast NHLF 0.612714 -0.706714 0.00820851983414126 0.304507242190339 DataSet_03_237
NR1D2 SOX11 siRNA Lung_fibroblast NHLF 0.585029 -0.773419 0.0313025647120378 0.274007721723901 DataSet_03_238
NR1D2 SOX9 knockdown Liver HepG2 0.628555 -0.669888 0.00129022548118556 0.0144322067062028 DataSet_03_248
NR1D2 SP1 siRNA Mammary_gland MDA-MB-231 1.66163 0.732595 0.207241989445144 0.430172815002053 DataSet_03_250
NR1D2 SRF siRNA Prostate LNCaP 0.620387 -0.68876 3.17677639012156e-05 0.000696991820953216 DataSet_03_254
NR1D2 TCEA1 siRNA Mammary_gland MCF7 1.50703 0.591703 0.178563956794081 0.999762252994287 DataSet_03_266
NR1D2 TP53 knockout Haematopoietic_and_lymphoid_tissue MOLP8 1.54688 0.629365 0.00327245341765324 0.402124361166128 DataSet_03_280
NR1D2 TP63 siRNA Skin Primary neonatal keratinocytes 0.192023 -2.38065 0.000211407003726988 0.00426376560368619 DataSet_03_281
NR1D2 WT1 siRNA Mammary_gland MCF7 0.637486 -0.649536 0.14514768960259 0.999957852801679 DataSet_03_285
NR1D2 ZNF750 siRNA Skin Primary neonatal keratinocytes 0.588795 -0.764162 0.00633885209410401 0.0641979157021846 DataSet_03_294
NR1D2 CIZ1 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.12195 1.08539 0.000282733147432908 0.018311055901814 DataSet_04_004
NR1D2 FUBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.90669 0.931068 0.00137299988217717 0.0536237768466547 DataSet_04_010
NR1D2 MARK2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.499232 -1.00222 0.02595446790892 0.0558112736788546 DataSet_04_012
NR1D2 NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 3.20923 1.68222 0.597092770566199 0.715510764102668 DataSet_04_014
NR1D2 NUP35 shRNA Haematopoietic_and_lymphoid_tissue K562 0.53149 -0.911885 0.0291061040239715 0.064521515326079 DataSet_04_015
NR1D2 ZNF574 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.624126 -0.680091 0.0190914212856572 0.127165565660668 DataSet_04_023
NR1D2 NFX1 CRISPR Liver HepG2 1.63667 0.710763 0.00229187085229409 0.0179341990925749 DataSet_04_032
NR1D2 ACTN4 CRISPR Liver HepG2 1.62405 0.699597 0.0075674596325488 0.0517682561911907 DataSet_04_042
NR1D2 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.646086 -0.630202 0.0768910894564911 0.553341101868115 DataSet_02_45
NR1D2 CNOT7 shRNA Haematopoietic_and_lymphoid_tissue K562 2.24918 1.1694 0.000640303659546685 0.0395443736754959 DataSet_04_061
NR1D2 HDGF shRNA Haematopoietic_and_lymphoid_tissue K562 0.605223 -0.724462 0.0440114415072075 0.0922411011985735 DataSet_04_059
NR1D2 SMARCA4 siRNA Colon HCT116 2.01832 1.01315 4.836931e-02 7.368841e-01 DataSet_03_301
NR1D2 LITAF siRNA Lymph KARPAS-231 0.66496 -0.588661 2.069267e-01 0.61417242 DataSet_03_309
NR1D2 LITAF siRNA Lymph VAL 0.662187 -0.59469 3.760668e-01 0.773228581 DataSet_03_310
NR1D2 ARID3B CRISPR Colon HCT15 1.96329 0.973275 - - DataSet_03_335
NR1D2 ZFX siRNA Prostate C4-2B 1.5215 0.605492 1.387517e-06 5.081559e-05 DataSet_03_348
NR1D2 SKI CRISPR Blood HL60 0.609779 -0.713643 8.708596e-02 0.416181885 DataSet_03_351
NR1D2 ESR1 siRNA Mammary_gland MCF7 2.39686 1.26115 6.966140e-05 0.0083477450 DataSet_03_352
NR1D2 TP53 CRISPR Brain U5-NPC 2.48109 1.31097 1.530763e-02 1.623145e-01 DataSet_03_358
NR1D2 RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 1.52246 0.606406 1.693727e-01 3.960356e-01 DataSet_03_359
NR1D2 MYC siRNA Peripheral_blood T lymphocyte 1.68811 0.75541 3.889228e-03 0.043504112 DataSet_03_363
NR1D2 ZNF148 shRNA Mammary_gland MDA-MB-231 0.655783 -0.608711 1.250368e-02 0.080661510 DataSet_03_366
NR1D2 DNMT3A knockout Embryo_kidney HEK293T 0.0453759 -4.46193 - - DataSet_03_369
NR1D2 ZFP36L1 siRNA Urinary_bladder J82 3.24379 1.69768 - - DataSet_03_371
NR1D2 E2F1 siRNA Nasopharynx HK1 1.52863 0.612243 1.749818e-02 1.674920e-01 DataSet_03_373
NR1D2 HNRNPU siRNA Colon RKO 1.57947 0.659438 - - DataSet_03_374
NR1D2 GLI1 siRNA Skeletal_muscle RMS13 1.86813 0.901598 1.598771e-02 0.099048842 DataSet_03_375
NR1D2 ZNF213 siRNA Mammary_gland MCF7 2.02046 1.01468 1.082944e-01 5.284786e-01 DataSet_03_376
NR1D2 DDX5 shRNA Stomach HGC-27 1.64696 0.719804 - - DataSet_03_379
NR1D2 ZBTB7A siRNA Stomach BGC823 0.632016 -0.661967 - - DataSet_03_380
NR1D2 YY1 knockdown Liver HepG2 1.57587 0.656149 1.614360e-03 7.622265e-03 DataSet_03_390
NR1D2 ILF2 siRNA Stomach SGC-7901 4.30185 2.10496 0.0025542983 0.02546153 DataSet_03_393
NR1D2 BMI1 shRNA Bile_duct QBC-939 1.66193 0.732857 1.583244e-04 0.0025360233 DataSet_03_395
NR1D2 TLE4 CRISPR Lymph CAR T Cell 0.598623 -0.74028 1.279362e-03 0.07771203 DataSet_03_398
NR1D2 RELA CRISPR Brain T30 0.64732 -0.627448 0.3380160194 0.8400824 DataSet_03_399
NR1D2 HMGA1 shRNA Bile_duct HUCCT1 1.58752 0.666779 2.668050e-02 0.195064793 DataSet_03_400
NR1D2 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 1.54628 0.628799 4.566072e-01 0.5870865 DataSet_03_403
NR1D2 SIRT1 siRNA Pancreas PANC1 0.664805 -0.588998 6.981613e-02 0.170635141 DataSet_03_410
NR1D2 USP22 shRNA Liver HuH7 40.1717 5.32811 - - DataSet_03_411
NR1D2 E2F6 shRNA Liver HuH7 0.652599 -0.615731 - - DataSet_03_412
NR1D2 ZKSCAN3 CRISPR Colon HCT116 0.571652 -0.806792 5.585734e-03 0.176072055 DataSet_03_415
NR1D2 RUNX2 shRNA Cord_blood Natural Killer Cell 0.429598 -1.21894 8.933003e-03 0.761676477 DataSet_03_416
NR1D2 FOXP3 CRISPR Peripheral_blood Naive Treg 0.428014 -1.22427 2.348856e-02 0.235186174 DataSet_03_427
NR1D2 USP7 shRNA Skin xenograft cells 0.43949 -1.1861 0.26315305 0.4348960 DataSet_03_431
NR1D2 PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.500614 -0.998231 - - DataSet_03_432
NR1D2 POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 2.38641 1.25484 2.342579e-03 0.177094257 DataSet_03_434
NR1D2 SETDB1 shRNA Colon HCT116 0.579059 -0.788218 - - DataSet_03_440
NR1D2 CAMTA1 knockout Embryo_kidney HEK293T 1.54214 0.624932 4.018379e-02 0.16803924 DataSet_03_448
NR1D2 CBX2 siRNA Mammary_gland MCF7 0.536758 -0.897656 1.499549e-04 0.0017260534 DataSet_03_451
NR1D2 IRF2 shRNA Cord_Blood CD34+ cells 1.6594 0.730662 - - DataSet_03_460
NR1D2 SOX9 knockout Liver HuH7 0.665097 -0.588364 8.573404e-03 3.858101e-02 DataSet_03_463
NR1D2 PARP1 knockout Embryo_kidney HEK293a 1.51029 0.594823 1.058789e-04 6.997052e-04 DataSet_03_464
NR1D2 STAT3 shRNA Liver HepG2 2.17156 1.11873 5.006576e-03 0.0978371419 DataSet_03_465
NR1D2 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 1.93421 0.951745 - - DataSet_03_467
Regulation Region
 
T(co)Fs that significantly regulate MCM2 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of NR1D2
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines