Gene Overview
Target Gene: RYR1
NCBI Official Symbol: RYR1
Entrez ID: 6261
Ensembl ID: ENSG00000196218
Gene Full Name: ryanodine receptor 1
Strand: +
Gene Locus: 19q13.2
External Links:

RYR1 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate RYR1   
T(co)Fs that Repress RYR1
The Intensity of the Gene Regulated by T(co)Fs:
RYR1-T(co)F Pairs
Target
Gene
T(co)F Knock
-Method
Tissue Type Biosample
Name
Fold
Change
Log2FC P-value Corrected
_P
Dataset ID
RYR1 SPDEF shRNA Mammary_gland MCF7 0.57188 -0.80622 0.98187 0.99999 DataSet_01_107
RYR1 FOXM1 siRNA Central_nervous_system U87 0.59991 -0.73719 - - DataSet_01_122
RYR1 POLR3A siRNA Mammary_gland MCF7 21 4.39232 - - DataSet_01_139
RYR1 JUN siRNA Peripheral_blood CD4+ T cells 0.63409 -0.65725 0.06413 0.2246 DataSet_01_164
RYR1 MAF siRNA Peripheral_blood CD4+ T cells 0.39827 -1.32819 0.00105 0.02559 DataSet_01_165
RYR1 TP53 siRNA Lung SAECs 3.12162 1.6423 0.03966 0.37246 DataSet_01_175
RYR1 GABPA shRNA Prostate C4-2B 2035.02 10.9908 0.23794 0.43934 DataSet_01_190
RYR1 GABPA shRNA Prostate LNCaP 989.712 9.95086 0.46038 0.7048 DataSet_01_191
RYR1 GATA2 siRNA Prostate LNCaP 1.57813 0.65821 0.08066 0.16841 DataSet_01_193
RYR1 TP63 siRNA Immortalized_keratinocyte HaCaT 1.84132 0.88074 - - DataSet_01_200
RYR1 TP63 siRNA Head_and_neck SCC-012 0.59371 -0.75216 - - DataSet_01_201
RYR1 XBP1 shRNA Mammary_gland T47D 0.66594 -0.58654 0.00159 0.00811 DataSet_01_203
RYR1 HIC1 shRNA Mammary_gland HBL100 3.24418 1.69785 - - DataSet_01_205
RYR1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 2.51716 1.3318 - - DataSet_01_208
RYR1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.3367 -1.57045 - - DataSet_01_210
RYR1 LIN28A siRNA Embryo H9 0.13668 -2.87113 9.12725e-05 0.00288 DataSet_01_215
RYR1 IRX1 shRNA Bone_marrow 143B 0.41079 -1.28354 0.38698 0.63369 DataSet_01_227
RYR1 TWIST1 shRNA Stomach CAF32 0.34565 -1.53262 0.00529 0.03724 DataSet_01_253
RYR1 TWIST1 shRNA Stomach CAF 0.51168 -0.96669 0.01719 0.52717 DataSet_01_254
RYR1 SOX4 shRNA Mammary_gland MDA-MB-231 1.87043 0.90337 0.04244 0.25182 DataSet_01_260
RYR1 POSTN shRNA Brain GSC272 17.3237 4.11468 0.00142 0.47578 DataSet_01_293
RYR1 TFAP4 siRNA Brain BE(2)-C 0.1888 -2.40509 0.34544 0.51625 DataSet_01_295
RYR1 PTEN shRNA Lung HCC827 2.21797 1.14924 0.2089 0.6739 DataSet_01_302
RYR1 SOX9 siRNA Prostate VCaP 5.25 2.39232 0.03879 0.9316 DataSet_01_308
RYR1 SOX9 siRNA Prostate VCaP 5.25 2.39232 0.03879 0.9316 DataSet_01_309
RYR1 HOXC6 siRNA Prostate LNCaP 0.5765 -0.7946 0.40313 0.99927 DataSet_01_333
RYR1 RBM17 shRNA Liver HepG2 0.14286 -2.80735 0.03092 0.27426 DataSet_02_100
RYR1 RBFOX2 shRNA Liver HepG2 2.57143 1.36257 0.92829 0.98059 DataSet_02_101
RYR1 TAF15 shRNA Liver HepG2 73 6.18982 0.00048 0.01075 DataSet_02_106
RYR1 HNRNPUL1 shRNA Liver HepG2 18 4.16993 4.98828e-05 0.0175 DataSet_02_109
RYR1 RBM39 shRNA Liver HepG2 2.14286 1.09954 0.12185 0.3571 DataSet_02_111
RYR1 BCLAF1 shRNA Liver HepG2 2 1 1 1 DataSet_02_112
RYR1 CEBPZ shRNA Liver HepG2 4 2 0.07147 1 DataSet_02_118
RYR1 PTBP1 shRNA Liver HepG2 6 2.58496 0.01778 0.03442 DataSet_02_120
RYR1 HNRNPLL shRNA Liver HepG2 2 1 1 1 DataSet_02_125
RYR1 SNRNP70 shRNA Liver HepG2 11 3.45943 0.44706 0.56265 DataSet_02_126
RYR1 SRSF3 shRNA Liver HepG2 9 3.16993 0.18973 0.33862 DataSet_02_127
RYR1 PRPF4 shRNA Liver HepG2 0.5 -1 1 1 DataSet_02_128
RYR1 POLR2G shRNA Haematopoietic_and_lymphoid_tissue K562 0.56075 -0.83458 0.02351 0.69659 DataSet_02_130
RYR1 SRSF7 shRNA Haematopoietic_and_lymphoid_tissue K562 0.52719 -0.9236 0.01107 0.22541 DataSet_02_133
RYR1 PCBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.31873 -1.64959 0.00041 0.18403 DataSet_02_137
RYR1 RBFOX2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.55028 -0.86176 0.04999 0.4709 DataSet_02_139
RYR1 FIP1L1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.40301 -1.31111 0.001 0.08322 DataSet_02_147
RYR1 ILF3 shRNA Haematopoietic_and_lymphoid_tissue K562 0.45251 -1.14397 0.05402 0.32055 DataSet_02_148
RYR1 NONO shRNA Haematopoietic_and_lymphoid_tissue K562 0.60211 -0.73189 0.0152 0.19424 DataSet_02_149
RYR1 SAFB2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.6218 -0.68547 0.09079 0.52223 DataSet_02_150
RYR1 ILF2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.65104 -0.61918 0.06258 0.33316 DataSet_02_152
RYR1 SRSF4 shRNA Haematopoietic_and_lymphoid_tissue K562 0.59981 -0.73743 0.05165 0.38992 DataSet_02_154
RYR1 PSIP1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.58492 0.66441 0.04187 0.13214 DataSet_02_158
RYR1 AGO1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.64302 0.71635 0.01169 0.53443 DataSet_02_162
RYR1 U2AF1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.22174 -2.17306 0.03492 0.18145 DataSet_02_165
RYR1 RBM25 shRNA Haematopoietic_and_lymphoid_tissue K562 0.4587 -1.12439 0.18316 0.40665 DataSet_02_166
RYR1 RBM22 shRNA Haematopoietic_and_lymphoid_tissue K562 0.49094 -1.02639 0.00335 0.05762 DataSet_02_168
RYR1 U2AF2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.22609 -2.14505 0.00876 0.05946 DataSet_02_170
RYR1 ZFX siRNA Prostate C4-2B 8 3 0.02261 0.05712 DataSet_02_172
RYR1 NFE2L2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.64327 -0.63651 0.20889 1 DataSet_02_174
RYR1 TBL1XR1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.60193 -0.73233 0.16634 1 DataSet_02_178
RYR1 VEZF1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.46779 -1.09606 0.00773 1 DataSet_02_179
RYR1 MAFG siRNA Haematopoietic_and_lymphoid_tissue K562 2.49913 1.32143 0.00712 1 DataSet_02_189
RYR1 TCP1 siRNA Haematopoietic_and_lymphoid_tissue K562 1.56366 0.64493 0.61142 1 DataSet_02_194
RYR1 UBTF siRNA Haematopoietic_and_lymphoid_tissue K562 0.66083 -0.59764 0.18978 1 DataSet_02_198
RYR1 E2F6 siRNA Haematopoietic_and_lymphoid_tissue K562 1.54609 0.62862 0.52039 1 DataSet_02_205
RYR1 ZFX siRNA Mammary_gland MCF7 0.24042 -2.05638 0.00109 0.03575 DataSet_02_206
RYR1 BCL6 siRNA Lymph OCI-Ly7 DLBCL 2.11026 1.07742 0.35200575442817 0.869578567731731 DataSet_03_025
RYR1 BCL6 siRNA Lymph Pfeiffer DLBCL 0.5348 -0.902928 0.169276806332976 0.647005369226647 DataSet_03_026
RYR1 FOXM1 siRNA Mammary_gland BT-20 cells 1.66667 0.736966 0.0871164351263946 0.50033384521145 DataSet_03_091
RYR1 GATA2 siRNA Uterus Decidual stromal cells 0.626723 -0.674099 0.815559465577688 0.98344137960202 DataSet_03_100
RYR1 GATA4 siRNA Stomach KatoIII 0.410853 -1.28331 0.0952539656711096 0.889431002741336 DataSet_03_106
RYR1 GATA6 siRNA Stomach AGS 3.49534 1.80543 0.170040100946219 0.672248481264149 DataSet_03_108
RYR1 GATA6 siRNA Stomach YCC3 0.32105 -1.63913 0.0220580696788119 0.5049339311783 DataSet_03_110
RYR1 GFP siRNA Mammary_gland BT-20 cells 2 1 1.08761392583465e-07 9.74812824383803e-05 DataSet_03_111
RYR1 HNF4a siRNA Liver HepG2 17.1 4.09592 5.75939875590559e-05 0.190404307163878 DataSet_03_126
RYR1 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 0.542276 -0.882901 0.636684284223654 0.999948959532916 DataSet_03_134
RYR1 KLF5 siRNA Stomach AGS 1.95309 0.96576 0.501081456470912 0.840423514987621 DataSet_03_149
RYR1 KLF5 siRNA Stomach KatoIII 1.59479 0.673363 0.408369224374456 0.786746282950123 DataSet_03_150
RYR1 KLF5 siRNA Stomach YCC3 0.546841 -0.870806 0.132472975941892 0.487377216109696 DataSet_03_151
RYR1 MTA2 siRNA Stomach SGC-7901 1.67301 0.742443 - - DataSet_03_169
RYR1 MYC siRNA Colon HT29 0.325878 -1.61759 - - DataSet_03_177
RYR1 NR2F2 siRNA Uterus Primary eutopic stromal cells 1.99426 0.995856 0.617562317415622 0.99947668859931 DataSet_03_202
RYR1 PHB shRNA Embryo Embryonic stem cells (ESCs) 0.525095 -0.92935 0.114784925291327 0.215651590545676 DataSet_03_211
RYR1 PRRX1 CRISPR Neuroblastoma 691-MES 2.18836 1.12985 0.0527210705297559 0.89189998148014 DataSet_03_217
RYR1 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.289474 -1.7885 - - DataSet_03_246
RYR1 SP1 siRNA Mammary_gland MDA-MB-231 0.501019 -0.997062 0.0945366080826439 0.413972819854456 DataSet_03_250
RYR1 STAT3 CRISPR Embryo hESC 4.101 2.03598 0.0380453431840646 0.109591948573377 DataSet_03_258
RYR1 STAT6 siRNA Umbilical_vein HUVEC 11 3.45943 0.210495022652137 0.852472382725311 DataSet_03_264
RYR1 TFE3 siRNA Kidney UOK257-2 0.0337324 -4.88972 - - DataSet_03_275
RYR1 ZNF750 siRNA Skin Primary neonatal keratinocytes 2.23133 1.1579 0.000507677894152514 0.0247766005560756 DataSet_03_294
RYR1 CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 0.646113 -0.630143 0.249947288884766 0.377535686493728 DataSet_04_002
RYR1 EIF2AK2 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.7643 0.819098 0.00477560608716168 0.442249488187847 DataSet_04_008
RYR1 FUBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.37011 1.24495 0.00699049872907588 0.0621676308585679 DataSet_04_010
RYR1 NUP35 shRNA Haematopoietic_and_lymphoid_tissue K562 1.57018 0.650926 0.132216321964135 0.200840209923393 DataSet_04_015
RYR1 PAN2 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.64413 0.717323 0.183548130038769 0.862034217236794 DataSet_04_016
RYR1 SMAD2 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.20248 1.13913 0.0199203781567515 0.103471636087997 DataSet_04_018
RYR1 CIZ1 CRISPR Liver HepG2 0.0434783 -4.52356 0.00248518411712033 0.172884254387876 DataSet_04_026
RYR1 CTCF CRISPR Liver HepG2 1.66667 0.736966 0.161826446665096 0.87075549477253 DataSet_04_027
RYR1 E4F1 CRISPR Liver HepG2 0.564103 -0.825971 0.426169224965032 0.674621261966383 DataSet_04_028
RYR1 MECP2 CRISPR Liver HepG2 1.54545 0.628031 0.0159847055642424 0.217569107660516 DataSet_04_031
RYR1 NFX1 CRISPR Liver HepG2 10.5 3.39232 0.272840384862996 0.366078842080859 DataSet_04_032
RYR1 PAN2 CRISPR Liver HepG2 0.48 -1.05889 0.2937795484366 0.468729210144335 DataSet_04_033
RYR1 SMAD5 CRISPR Liver HepG2 0.56 -0.836501 0.40771677189135 0.735518960646162 DataSet_04_036
RYR1 SRPK2 CRISPR Liver HepG2 2.36364 1.24101 0.00975444420559077 0.130422505439901 DataSet_04_037
RYR1 ZNF574 CRISPR Liver HepG2 0.32 -1.64386 0.127893437995467 0.251303224038977 DataSet_04_041
RYR1 APTX CRISPR Liver HepG2 1.66667 0.736966 0.822682452423404 0.99600891928032 DataSet_04_069
RYR1 CHCHD3 CRISPR Liver HepG2 4.2 2.07039 0.392105840629335 0.702736422414334 DataSet_04_067
RYR1 CNOT7 CRISPR Liver HepG2 3 1.58496 0.274332616383238 0.436625028096477 DataSet_04_045
RYR1 PAN2 CRISPR Liver HepG2 0.285714 -1.80735 0.45829655930498 0.636482603734709 DataSet_04_066
RYR1 RIOK2 CRISPR Liver HepG2 2.28571 1.19265 0.565949494027202 1 DataSet_04_070
RYR1 SEPT11 CRISPR Liver HepG2 0.5 -1 0.900430503756078 0.964128407463138 DataSet_04_068
RYR1 ABT1 shRNA Liver HepG2 9 3.16992 0.296037400206695 0.425232468176697 DataSet_04_052
RYR1 CNOT7 shRNA Liver HepG2 1.89286 0.920566 0.324468968179728 0.431108067942204 DataSet_04_051
RYR1 DDX1 shRNA Liver HepG2 0.5 -1 0.928723887981523 0.975812401808597 DataSet_04_057
RYR1 NPM1 shRNA Liver HepG2 0.285714 -1.80735 0.775917878398077 0.964266725860191 DataSet_04_058
RYR1 UBE2L3 shRNA Liver HepG2 0.117647 -3.08746 0.363940607254556 0.520687121209915 DataSet_04_055
RYR1 YBX3 shRNA Liver HepG2 0.5 -1 0.928055273697749 0.969157920067361 DataSet_02_98
RYR1 HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.535597 -0.90078 0.0127595109000171 0.393478982766751 DataSet_02_75
RYR1 LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.65103 -0.619205 0.0609944246079331 0.143242486012295 DataSet_02_35
RYR1 TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.487414 -1.03678 0.0979960947368938 0.190936690006987 DataSet_02_33
RYR1 ABT1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.6548 1.40861 0.0125000585589094 0.0596267161143378 DataSet_04_060
RYR1 DDX1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.513967 -0.960254 0.0186491483059477 0.434540057802768 DataSet_04_063
RYR1 HDGF shRNA Haematopoietic_and_lymphoid_tissue K562 1.53289 0.616259 0.135635723710863 0.22718257834624 DataSet_04_059
RYR1 ELF3 CRISPR Bile_duct HBDEC2 0.582824 -0.778867 2.194234e-04 2.073881e-03 DataSet_03_304
RYR1 AEBP1 siRNA Central_nervous_system U87MG 0.592107 -0.75607 9.880059e-02 0.9999434 DataSet_03_338
RYR1 BRCA1 siRNA Mammary_gland MCF7 1.7095 0.773574 4.946461e-01 0.9999931 DataSet_03_308
RYR1 SKI CRISPR Blood HL60 0.333333 -1.58496 3.108157e-01 0.615851377 DataSet_03_351
RYR1 ESR1 siRNA Mammary_gland MCF7 2.38042 1.25122 1.940878e-04 0.0110678024 DataSet_03_352
RYR1 ETV5 knockdown Colon HT29 0.294118 -1.76553 1.230166e-01 0.374840306 DataSet_03_353
RYR1 PARP1 siRNA Prostate LNCaP 1.70935 0.773445 5.746829e-01 0.790258310 DataSet_03_354
RYR1 TET1 CRISPR Mammary_gland Hs578T 0.466881 -1.09887 6.611657e-01 8.069161e-01 DataSet_03_355
RYR1 TP53 CRISPR Brain U5-NPC 2 1 2.254215e-01 3.582256e-01 DataSet_03_358
RYR1 ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 0.562508 -0.830055 8.812465e-01 9.180229e-01 DataSet_03_362
RYR1 TP53 knockout Stomach SNU1 0.510567 -0.969828 0.5835881215 0.9603114 DataSet_03_365
RYR1 ZNF148 shRNA Mammary_gland MDA-MB-231 0.631428 -0.66331 9.334026e-01 0.973696860 DataSet_03_366
RYR1 DNMT3A knockout Embryo_kidney HEK293T 0.00376683 -8.05243 - - DataSet_03_369
RYR1 E2F1 siRNA Nasopharynx HK1 0.5 -1 1.835069e-15 3.734365e-11 DataSet_03_373
RYR1 GLI1 siRNA Skeletal_muscle RMS13 2.19585 1.13478 3.706758e-02 0.162089383 DataSet_03_375
RYR1 ZNF213 siRNA Mammary_gland MCF7 0.576498 -0.794612 5.124986e-01 7.336519e-01 DataSet_03_376
RYR1 EZH2 CRISPR Ovary SKOV3 0.570312 -0.810175 1.185429e-01 0.3060952037 DataSet_03_378
RYR1 TCF19 CRISPR Oral_squamous CAL27 1.51443 0.598778 9.376184e-02 0.3164630827 DataSet_03_383
RYR1 YY1 shRNA Brain GSC1517 0.311324 -1.68351 - - DataSet_03_384
RYR1 YY1 shRNA Brain GSC23 2 1 - - DataSet_03_385
RYR1 NFKBIA shRNA Bone_marrow U2OS 0.379762 -1.39683 3.827786e-01 0.87005461 DataSet_03_389
RYR1 YY1 knockdown Liver HepG2 1.75 0.807355 6.934879e-01 7.770812e-01 DataSet_03_390
RYR1 KDM5A CRISPR Lung GLC16 1.79522 0.844158 7.508903e-01 0.855532620 DataSet_03_392
RYR1 ASXL1 CRISPR Embryo iPSC 0.35202 -1.50627 0.0413531136 0.8048302 DataSet_03_394
RYR1 JAZF1 siRNA Cervix HeLa Kyoto 1.65163 0.723894 7.064865e-01 0.952522679 DataSet_03_396
RYR1 RELA CRISPR Brain T30 41.9772 5.39153 0.7182341349 0.9260101 DataSet_03_399
RYR1 HMGA1 shRNA Bile_duct HUCCT1 0.285714 -1.80736 7.075328e-01 0.854513785 DataSet_03_400
RYR1 TFAP2A knockout Embryo H9 1.88073 0.911296 2.844496e-02 0.10678957 DataSet_03_405
RYR1 SATB2 CRISPR Colon Colon organoid 0.2 -2.32193 1.629979e-01 0.95735254 DataSet_03_406
RYR1 STRAP knockout Nerve SK-N-AS 14.8205 3.88953 - - DataSet_03_409
RYR1 E2F2 siRNA Prostate LNCaP 0.416667 -1.26303 4.778703e-03 4.017017e-02 DataSet_03_414
RYR1 RUNX2 shRNA Cord_blood Natural Killer Cell 2 1 6.635002e-01 0.893847372 DataSet_03_416
RYR1 NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 1.77037 0.824051 4.722230e-02 0.158205086 DataSet_03_418
RYR1 PRDM1 CRISPR Lymph CD8+ T cells 0.388889 -1.36257 - - DataSet_03_421
RYR1 MAEL CRISPR Liver Alexander cells 0.26087 -1.9386 - - DataSet_03_423
RYR1 STAT5B CRISPR Embryo_kidney HEK293 0.55 -0.862496 2.248863e-01 0.665084591 DataSet_03_424
RYR1 LHX2 shRNA Bone_marrow ES-derived RPE cells 0.533333 -0.906891 1.821439e-01 1.000000e+00 DataSet_03_428
RYR1 IKZF2 shRNA Lymph Hut78 0.394969 -1.34019 1.574489e-01 0.64858940 DataSet_03_429
RYR1 USP7 shRNA Skin xenograft cells 0.408795 -1.29055 0.23530569 0.4348960 DataSet_03_431
RYR1 POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.631579 -0.662965 3.488242e-01 0.574894029 DataSet_03_434
RYR1 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 2.46316 1.30051 6.018437e-02 0.88698055 DataSet_03_439
RYR1 ARID1A shRNA Bile_duct MMNK1 0.245769 -2.02463 2.438287e-01 0.545953811 DataSet_03_458
RYR1 PARP1 knockout Embryo_kidney HEK293a 3.68153 1.88031 3.248388e-06 3.780099e-05 DataSet_03_464
RYR1 SMARCA1 Cas13 Embryo_kidney HEK293T 0.25 -2 - - DataSet_03_466
RYR1 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 3.86111 1.94902 - - DataSet_03_467
RYR1 CREBBP CRISPR Lymph U2932 0.658537 -0.602664 7.623938e-01 1.0000000 DataSet_03_474
RYR1 CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 0.646113 -0.630143 0.1792916 0.317465869 DataSet_04_074
Regulation Region

Expression Atlas of RYR1