Gene Overview
| Target Gene: | TMC3 |
| NCBI Official Symbol: | TMC3 |
| Entrez ID: | 342125 |
| Ensembl ID: | ENSG00000188869 |
| Gene Full Name: | transmembrane channel like 3 |
| Strand: | - |
| Gene Locus: | 15q25.1 |
| External Links: |
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TMC3 Significantly Regulated by These T(co)Fs
T(co)Fs
that Activate TMC3
T(co)Fs
that Repress TMC3
The Intensity of the Gene Regulated by T(co)Fs:
TMC3-T(co)F Pairs
| Target Gene |
T(co)F | Knock -Method |
Tissue Type | Biosample Name |
Fold Change |
Log2FC | P-value | Corrected _P |
Dataset ID |
|---|---|---|---|---|---|---|---|---|---|
| TMC3 | ZIC2 | siRNA | Pancreas | PANC1 | 1.55658 | 0.63838 | - | - | DataSet_01_121 |
| TMC3 | HOXB7 | siRNA | Pancreas | MIA PaCa-2 | 0.49629 | -1.01074 | 0.02416 | 0.59755 | DataSet_01_169 |
| TMC3 | GATA2 | siRNA | Prostate | LNCaP | 1.82044 | 0.86429 | 0.19529 | 0.31714 | DataSet_01_193 |
| TMC3 | REST | siRNA | Prostate | LNCaP | 0.04616 | -4.4372 | 2.61666e-06 | 0.00945 | DataSet_01_211 |
| TMC3 | FOXO3 | siRNA | Pancreas | PANC1 | 0.40838 | -1.29201 | - | - | DataSet_01_267 |
| TMC3 | ESRRA | shRNA | Embryo_kidney | 293T | 2.84653 | 1.5092 | 0.11746 | 0.7178 | DataSet_01_280 |
| TMC3 | MYC | siRNA | Colon | HCT116 | 1.72314 | 0.78504 | 0.37569 | 0.44539 | DataSet_01_324 |
| TMC3 | FOXO1 | siRNA | Skin | primary human dermal lymphatic endothelial cells | 2.35938 | 1.23841 | - | - | DataSet_03_096 |
| TMC3 | MEF2D | shRNA | Liver | HuH7 | 1.61092 | 0.687884 | - | - | DataSet_03_162 |
| TMC3 | MITF | siRNA | Skin | SK-MEL-5 | 0.608624 | -0.716377 | 0.0016441180978441 | 0.00504738689944304 | DataSet_03_168 |
| TMC3 | SOX11 | siRNA | Lung_fibroblast | NHLF | 0.329505 | -1.60163 | 0.405727687786227 | 0.623854502497829 | DataSet_03_237 |
| TMC3 | SP1 | siRNA | Mammary_gland | MDA-MB-231 | 0.486493 | -1.03951 | 0.156572529955637 | 0.413972819854456 | DataSet_03_250 |
| TMC3 | ZNF746 | siRNA | Colon | HCT116 | 2.00834 | 1.006 | - | - | DataSet_03_293 |
| TMC3 | SNAI2 | shRNA | Pancreas | pancreatic cancer stem cells | 1.66757 | 0.73775 | 1.318050e-01 | 0.6510154 | DataSet_03_306 |
| TMC3 | ACTR5 | siRNA | Muscle | RD | 2.83977 | 1.50577 | - | - | DataSet_03_343 |
| TMC3 | ZFX | siRNA | Mammary_gland | MCF7 | 1.80838 | 0.854699 | 1.959188e-02 | 9.420974e-02 | DataSet_03_349 |
| TMC3 | ESR1 | siRNA | Mammary_gland | MCF7 | 0.551906 | -0.857505 | 2.206412e-02 | 0.1118106937 | DataSet_03_352 |
| TMC3 | RUNX1 | shRNA | Haematopoietic_and_lymphoid_tissue | OCI-AML5 | 0.571018 | -0.808392 | 8.350660e-01 | 9.332200e-01 | DataSet_03_359 |
| TMC3 | USP22 | shRNA | Liver | PLC_PRF_5 cells | 1.55556 | 0.63743 | 2.082917e-01 | 0.42979195 | DataSet_03_368 |
| TMC3 | GLI1 | siRNA | Skeletal_muscle | RMS13 | 0.352389 | -1.50476 | 4.437167e-02 | 0.179968878 | DataSet_03_375 |
| TMC3 | EZH2 | CRISPR | Ovary | SKOV3 | 0.137931 | -2.85798 | 3.597830e-03 | 0.0429393654 | DataSet_03_378 |
| TMC3 | NFKB2 | siRNA | Bone_marrow | U2OS | 4 | 2 | 2.353099e-01 | 0.57739488 | DataSet_03_381 |
| TMC3 | DNMT1 | siRNA | Skin | Human melanoma cells | 2.85256 | 1.51226 | 3.311210e-01 | 4.413930e-01 | DataSet_03_382 |
| TMC3 | YY1 | shRNA | Brain | GSC1517 | 0.5 | -1 | - | - | DataSet_03_384 |
| TMC3 | YY1 | shRNA | Brain | GSC23 | 0.333333 | -1.58496 | - | - | DataSet_03_385 |
| TMC3 | YY1 | shRNA | Brain | GSC3028 | 2.2 | 1.1375 | - | - | DataSet_03_386 |
| TMC3 | NFKBIA | shRNA | Bone_marrow | U2OS | 0.0030896 | -8.33836 | 7.838012e-01 | 0.90817387 | DataSet_03_389 |
| TMC3 | ILF2 | siRNA | Stomach | SGC-7901 | 1.75 | 0.807355 | 0.8364888019 | 0.89100086 | DataSet_03_393 |
| TMC3 | BMI1 | shRNA | Bile_duct | QBC-939 | 0.220254 | -2.18276 | 2.744278e-01 | 0.4952723365 | DataSet_03_395 |
| TMC3 | IKZF2 | CRISPR | Lymph | CAR T Cell | 2.13727 | 1.09577 | 9.353242e-01 | 0.999939484 | DataSet_03_397 |
| TMC3 | TLE4 | CRISPR | Lymph | CAR T Cell | 2.22014 | 1.15065 | 9.374835e-01 | 0.99300387 | DataSet_03_398 |
| TMC3 | HMGA1 | shRNA | Bile_duct | HUCCT1 | 1.92857 | 0.947533 | 7.465925e-01 | 0.878271136 | DataSet_03_400 |
| TMC3 | EHF | shRNA | Stomach | MKN7 | 0.0595441 | -4.0699 | - | - | DataSet_03_402 |
| TMC3 | JARID2 | siRNA | Adipose_tissue | human adipose tissue derived stem cells | 8 | 3 | 1.171295e-01 | 0.3387632 | DataSet_03_403 |
| TMC3 | TFAP2A | knockout | Embryo | H9 | 0.408451 | -1.29177 | 3.728066e-02 | 0.12350604 | DataSet_03_405 |
| TMC3 | E2F1 | siRNA | Prostate | LNCaP | 0.333333 | -1.58496 | 2.096276e-01 | 0.7226289181 | DataSet_03_413 |
| TMC3 | E2F2 | siRNA | Prostate | LNCaP | 2.5 | 1.32193 | 4.668217e-02 | 1.787043e-01 | DataSet_03_414 |
| TMC3 | NFATC2 | shRNA | Haematopoietic_and_lymphoid_tissue | THP-1 | 0.4375 | -1.19264 | 5.122424e-01 | 0.653859225 | DataSet_03_418 |
| TMC3 | FOXK2 | shRNA | Ovary | OVCAR-5 | 5.5 | 2.45943 | 7.255028e-02 | 0.22637909 | DataSet_03_419 |
| TMC3 | MAEL | CRISPR | Liver | Alexander cells | 0.6 | -0.736966 | - | - | DataSet_03_423 |
| TMC3 | LHX2 | shRNA | Bone_marrow | ES-derived RPE cells | 0.0824742 | -3.59991 | 4.216758e-05 | 1.810401e-02 | DataSet_03_428 |
| TMC3 | IKZF2 | shRNA | Lymph | Hut78 | 1.50903 | 0.593625 | 3.768076e-01 | 0.74813181 | DataSet_03_429 |
| TMC3 | USP7 | shRNA | Skin | xenograft cells | 0.390909 | -1.35509 | 0.30340501 | 0.4466712 | DataSet_03_431 |
| TMC3 | SUFU | shRNA | Mammary_gland | HCC1954 cells | 8 | 3 | 0.1672622350 | 0.6455297 | DataSet_03_437 |
| TMC3 | CIC | knockout | Brain | Immortalized Astrocyte Cells | 3.5 | 1.80736 | 1.139536e-02 | 2.020467e-01 | DataSet_03_438 |
| TMC3 | SETDB1 | shRNA | Colon | HCT116 | 7.45922 | 2.89902 | - | - | DataSet_03_440 |
| TMC3 | FOSL1 | siRNA | Prostate | MSKPCa3 | 0.568182 | -0.815575 | 0.0421692543 | 0.4361780 | DataSet_03_445 |
| TMC3 | CAMTA1 | knockout | Embryo_kidney | HEK293T | 2.15385 | 1.10691 | 5.442740e-03 | 0.09634106 | DataSet_03_448 |
| TMC3 | RELB | CRISPR | Colon | SW480 | 1.78571 | 0.836501 | 3.133275e-02 | 1.469719e-01 | DataSet_03_449 |
| TMC3 | CBX2 | siRNA | Mammary_gland | MDA-MB-231 | 2.50579 | 1.32526 | 6.094070e-01 | 7.921916e-01 | DataSet_03_450 |
| TMC3 | ZFP36L1 | CRISPR | Lung | NCI-H1876 | 1.61734 | 0.693627 | 7.603035e-01 | 0.992664775 | DataSet_03_454 |
| TMC3 | HAND1 | siRNA | Placenta | HPMVEC | 0.25 | -2 | 3.600813e-02 | 0.9463341 | DataSet_03_459 |
| TMC3 | PARP1 | knockout | Embryo_kidney | HEK293a | 8.1 | 3.01792 | 7.513442e-06 | 7.578327e-05 | DataSet_03_464 |
| TMC3 | STAT3 | shRNA | Liver | HepG2 | 0.5 | -1 | 6.077339e-01 | 0.7954453166 | DataSet_03_465 |
| TMC3 | SMARCA1 | CRISPR-Csm | Embryo_kidney | HEK293T | 0.5 | -1 | - | - | DataSet_03_467 |
| TMC3 | WHSC1 | siRNA | Prostate | PC3 | 0.5 | -1 | 6.186208e-01 | 0.77380939 | DataSet_03_471 |
| TMC3 | EZH2 | siRNA | Prostate | LNCaP | 1.73795 | 0.797388 | - | - | DataSet_03_472 |
Regulation Region