About Enhancer
| Enhancer ID: | E_00006 |
| Species: | Homo sapiens |
| Position : | chr1:47680000-47681000   |
| Year: | 2026 |
| Title: | Transcription factor cooperativity at a GATA3 tandem DNA sequence determines oncogenic enhancer-mediated activation |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 42024500 |
| MONDO: | MONDO:0004947 |
| Tissue: | Blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | MOLT4 Cells |
| CVCL ID: | CVCL_0013 |
| Cell Type: | T lymphoblast |
| Cell Ontology ID: | CL:0002419 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ATAC-seq, ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR Knockout, ChIP-RT-qPCR, RT-RT-qPCR, 3C-seq |
About Target Gene
| Target gene : | TAL1 |
About TF
| TF name : | GATA3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA3 | C-MYB transcription factor network | pid | 87 |
| GATA3 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| GATA3 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA3 | Glucocorticoid receptor regulatory network | pid | 85 |
| GATA3 | IL27-mediated signaling events | pid | 26 |
| GATA3 | Notch signaling pathway | pid | 58 |
| GATA3 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| GATA3 | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| GATA3 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00233 | chr1:47679000-47722000 | Blood | chronic myeloid leukemia cell | chronic myeloid leukemia |
| E_00005 | chr1:47680000-47681000 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00007 | chr1:47680000-47681000 | Blood | Jurkat T-ALL | T-cell acute lymphoblastic leukemia |
| E_01035 | chr1:47680000-47681000 | Eye | retinal pigment epithelial cell | -- |
| E_03497 | chr1:47680000-47681000 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer