About Enhancer
| Enhancer ID: | E_00012 |
| Species: | Homo sapiens |
| Position : | chr2:116230440-116232740   |
| Year: | 2026 |
| Title: | MYC-bound enhancer RNAs in cis regulate gene transcription and tumorigenesis |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Breast invasive carcinoma |
| PMID: | 42030388 |
| MONDO: | MONDO:0006143 |
| Tissue: | Mammary gland |
| Tissue Ontology ID: | UBERON:0001911 |
| Cell Source: | MCF-7 |
| CVCL ID: | CVCL_0031 |
| Cell Type: | Estrogen receptor positive breast cancer cell |
| Cell Ontology ID: | CL:0000646 |
| Experiment Type: | Luciferase reporter assay, loss-of-function ASO/shRNA knockdown, ChIP-qPCR, Pol II ChIA-PET chromatin interaction |
| High Throughput Method: | eCLIP-seq, ChIP-seq, ATAC-seq, RNA-seq, GRO-seq, ChIA-PET, TCGA/CCLE multi-omics |
| Low Throughput Method: | qRT-PCR, dual-luciferase reporter, , RNA FISH super-resolution imaging, subcellular fractionation, xenograft in vivo tumor assay |
About Target Gene
| Target gene : | GREB1 |
About TF
| TF name : | BRD4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00008 | chr2:116230440-116232740 | Mammary gland | Estrogen receptor positive breast cancer cell | Breast invasive carcinoma |
| E_00009 | chr2:116230440-116232740 | Mammary gland | Estrogen receptor positive breast cancer cell | Breast invasive carcinoma |
| E_00010 | chr2:116230440-116232740 | Mammary gland | Estrogen receptor positive breast cancer cell | Breast invasive carcinoma |
| E_00011 | chr2:116230440-116232740 | Mammary gland | Estrogen receptor positive breast cancer cell | Breast invasive carcinoma |
| E_00013 | chr2:116230440-116232740 | Mammary gland | Estrogen receptor positive breast cancer cell | Breast invasive carcinoma |
Expression of Target Genes for the Enhancer