About Enhancer
| Enhancer ID: | E_00014 |
| Species: | Homo sapiens |
| Position : | chr2:127082600-127082962   |
| Year: | 2019 |
| Title: | Brain cell type-specific enhancer-promoter interactome maps and disease risk association |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Alzheimer's disease |
| PMID: | 31727856 |
| MONDO: | MONDO:0004992 |
| Tissue: | Brain microglia |
| Tissue Ontology ID: | CL:0000129 |
| Cell Source: | hPSC-derived microglia |
| CVCL ID: | |
| Cell Type: | Human pluripotent stem cell derived microglia |
| Cell Ontology ID: | CL:0000129 |
| Experiment Type: | CRISPR-Cas9 loss-of-function deletion, PLAC-seq chromatin interaction, ChIP-qPCR |
| High Throughput Method: | ATAC-seq, H3K27ac ChIP-seq, H3K4me3 ChIP-seq, PLAC-seq, RNA-seq, LDSC GWAS heritability analysis |
| Low Throughput Method: | qRT-PCR, dual-luciferase reporter, , RNA FISH super-resolution imaging, subcellular fractionation, xenograft in vivo tumor assay |
About Target Gene
| Target gene : | BIN1 |
About TF
| TF name : | PU.1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
2 found
Expression of Target Genes for the Enhancer