About Enhancer
| Enhancer ID: | E_00024 |
| Species: | Homo sapiens |
| Position : | chr12:4900187-4901013   |
| Year: | 2025 |
| Title: | Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | B-cell acute lymphoblastic leukemia |
| PMID: | 40729681 |
| MONDO: | MONDO:0004945 |
| Tissue: | Bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | RS4;11 |
| CVCL ID: | CVCL_0093 |
| Cell Type: | B-ALL blast cell |
| Cell Ontology ID: | CL:0000692 |
| Experiment Type: | CRISPR-Cas9 deletion loss-of-function, Capture-C chromatin interaction, ChIP-qPCR |
| High Throughput Method: | ATAC-seq, H3K27ac CUT&Tag, ChIP-seq, RNA-seq, Micro-Capture-C |
| Low Throughput Method: | WGS, RT-qPCR, CRISPR editing, cell transfection |
About Target Gene
| Target gene : | ARID1B |
About TF
| TF name : | AFF1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00023 | chr12:4900187-4901013 | Bone marrow | B-ALL blast cell | B-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer