About Enhancer
| Enhancer ID: | E_00025 |
| Species: | Homo sapiens |
| Position : | chr6:101482232-101483107   |
| Year: | 2025 |
| Title: | Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | B-cell acute lymphoblastic leukemia |
| PMID: | 40729681 |
| MONDO: | MONDO:0004945 |
| Tissue: | Bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Primary human KMT2A::AFF1 ALL blasts |
| CVCL ID: | |
| Cell Type: | Primary leukemic blast cell |
| Cell Ontology ID: | CL:0000692 |
| Experiment Type: | Micro-Capture-C chromatin interaction + patient gene expression validation, ChIP-qPCR |
| High Throughput Method: | scMultiome ATAC+RNA-seq, TOPmentation H3K27ac profiling, Micro-Capture-C, WGS |
| Low Throughput Method: | RT-qPCR, FACS cell sorting, patient primary cell culture |
About Target Gene
| Target gene : | MEIS1 |
About TF
| TF name : | KMT2A::AFF1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00026 | chr6:101482232-101483107 | Bone marrow | Primary leukemic blast cell | B-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer