About Enhancer
| Enhancer ID: | E_00050 |
| Species: | Mus musculus |
| Position : | chr10:90723100-90723900   |
| Year: | 2018 |
| Title: | CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Obesity due to Sim1 haploinsufficiency |
| PMID: | 30545847 |
| MONDO: | MONDO:0012649 |
| Tissue: | Hypothalamus |
| Tissue Ontology ID: | UBERON:0001898 |
| Cell Source: | mouse primary hypothalamic neuron |
| CVCL ID: | |
| Cell Type: | hypothalamic neuron |
| Cell Ontology ID: | CL:0000641 |
| Experiment Type: | CRISPRa gain-of-function, ChIP-qPCR, in vivo transgenic reporter validation |
| High Throughput Method: | RNA-seq, ChIP-seq |
| Low Throughput Method: | dual-luciferase reporter assay, stereotaxic AAV injection, qRT-PCR, transgenic mouse line generation, body weight phenotyping |
About TF
| TF name : | Sim1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm10)
3 found
Expression of Target Genes for the Enhancer