About Enhancer
| Enhancer ID: | E_00053 |
| Species: | Homo sapiens |
| Position : | chr7:131323622-131334609   |
| Year: | 2024 |
| Title: | CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | Triple-negative breast cancer |
| PMID: | 39186674 |
| MONDO: | MONDO:0005228 |
| Tissue: | Mammary gland |
| Tissue Ontology ID: | UBERON:0001911 |
| Cell Source: | MDA-MB-468 |
| CVCL ID: | CVCL_0419 |
| Cell Type: | Triple-negative breast cancer cell line |
| Cell Ontology ID: | CL:0009071 |
| Experiment Type: | CRISPR-Cas9 knockout loss-of-function, dCas9-KRAB CRISPRi repression, Hi-C chromatin looping validation, CasRx eRNA knockdown |
| High Throughput Method: | ChIP-seq(H3K27ac), GRO-seq, ATAC-seq, RNA-seq, Hi-C, scATAC-seq, scRNA-seq, TCGA bulk omics |
| Low Throughput Method: | qRT-PCR, transwell migration assay, crystal violet proliferation assay, mouse mammary fat pad xenograft, tail vein metastasis model, IHC staining |
About Target Gene
| Target gene : | PODXL |
About TF
| TF name : |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
2 found
Expression of Target Genes for the Enhancer