About Enhancer
| Enhancer ID: | E_00058 |
| Species: | Homo sapiens |
| Position : | chr20:63680793-63682109   |
| Year: | 2025 |
| Title: | Systematic decoding of functional enhancer connectomes and risk variants in human glioma |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Glioblastoma multiforme |
| PMID: | 40830415 |
| MONDO: | MONDO:0001628 |
| Tissue: | Brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | U87 |
| CVCL ID: | CVCL_0022 |
| Cell Type: | glioma cell line |
| Cell Ontology ID: | CL:0000917 |
| Experiment Type: | CRISPR-Cas9 full locus knockout, dCas9-KRAB CRISPRi, dual-luciferase reporter assay, 3C-qPCR, ChIP-qPCR, SNP base editing |
| High Throughput Method: | HiChIP, H3K27ac ChIP-seq, RNA-seq, scATAC-seq, GWAS variant mapping |
| Low Throughput Method: | qRT-PCR, colony formation assay, glioma stem sphere assay, mouse intracranial xenograft, site-directed mutagenesis |
About Target Gene
| Target gene : | SOX18 |
About TF
| TF name : | MEIS1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MEIS1 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
13 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01308 | chr20:63680288-63681605 | Brain | glioblastoma cell | glioblastoma |
| E_01309 | chr20:63680288-63681605 | Brain | glioblastoma cell | glioblastoma |
| E_01310 | chr20:63680288-63681605 | Brain | glioblastoma cell | glioblastoma |
| E_00056 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00057 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00084 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00085 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00086 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00087 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00119 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00120 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00121 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00122 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
Expression of Target Genes for the Enhancer